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List of works by Patrick J Pollard

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

scientific article published on 2 May 2013

Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma.

scientific article published on 07 September 2006

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

scientific article

Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations

scientific article published on 06 June 2006

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

scientific article

Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome.

scientific article published on 27 July 2006

Cancer. Puzzling patterns of predisposition

scientific article

Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers

scientific article published on 14 April 2008

Comparative bioenergetic assessment of transformed cells using a cell energy budget platform

scientific article published on 17 October 2011

Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells

scientific article published on June 2014

Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours.

scientific article published on 10 February 2009

Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

scientific article published on 30 November 2005

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

scientific article published on 21 July 2010

Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations

scientific article published on 5 September 2006

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

scientific article published on 26 October 2010

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

scientific article published on 15 February 2017

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

scientific article published in March 2012

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency

scientific article published on 01 June 2003

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

scientific article published on 21 April 2009

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

scientific article published on 13 December 2013

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

scientific article

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

scientific article published on 26 July 2013

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

scientific article

Hypoxia signaling in hematopoietic stem cells: a double-edged sword

scientific article published on 01 September 2010

In the ring with polycystic kidney disease—avoiding the knockout punch

scientific article published on 01 January 2011

Inborn and acquired metabolic defects in cancer

scientific article published on 08 February 2011

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

scientific article published on 14 March 2013

Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia

scientific article published on May 2005

Myosin V-mediated vacuole distribution and fusion in fission yeast.

scientific article

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

scientific article

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

scientific article

Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences

scientific article published on 03 July 2013

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

scientific article

SDH mutations in cancer

scientific article published on July 13, 2011

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

scientific article published on 6 October 2010

Succinate: A New Epigenetic Hacker

scientific article published on June 10, 2013

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

scientific journal article

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression

scientific article published on 25 February 2009

The C-terminus of Apc does not influence intestinal adenoma development or progression

scientific article

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

scientific article published on January 2003