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List of works by Rehana K. Leak

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

scientific article published on 07 September 2018

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

scientific article published on 06 June 2016

ATP induces mild hypothermia in rats but has a strikingly detrimental impact on focal cerebral ischemia.

scientific article published on 17 October 2012

Adaptation and sensitization to proteotoxic stress.

scientific article published on 05 August 2013

Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism

scientific article

Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia

scientific article published on 03 October 2013

Aging of cerebral white matter.

scientific article published on 16 November 2016

Alpha-synuclein: prion or prion-like?

scientific article published on 12 August 2019

Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury

scientific article published on January 2015

Astrocyte plasticity revealed by adaptations to severe proteotoxic stress ⬇️

scientific article published on February 19, 2013

Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress

scientific article published on 05 April 2019

Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury

scientific article published on 15 September 2015

Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation

scientific article

Calbindin-D28K cells in the hamster SCN express light-induced Fos

scientific article published on 01 April 1996

Corrigendum to "Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation" [Redox Biol. 17 (2018) 323-337]

scientific article published on 21 December 2018

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.

scientific article

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

scientific article

Cytotoxicity models of Huntington's disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies

scientific article published on 12 August 2019

Delivery of neurotherapeutics across the blood brain barrier in stroke.

scientific article published on January 2012

Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

scientific article published on 01 October 2018

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.

scientific article

Drug conjugates—an emerging approach to treat breast cancer.

scientific article

Drug-induced hypothermia in stroke models: does it always protect?

scientific article

Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning

scientific article published on 4 September 2006

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

scientific article

Enhancing and Extending Biological Performance and Resilience

scientific article published on 01 July 2018

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury

scientific article

Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease.

scientific article published on 4 November 2017

Fast free-of-acrylamide clearing tissue (FACT)-an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue

scientific article published on 29 August 2017

From apoplexy to stroke: historical perspectives and new research frontiers.

scientific article

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

scientific article

Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys ⬇️

scientific article published on December 29, 2011

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.

scientific article

HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity ⬇️

scientific article published on May 1, 2013

Heat shock proteins in neurodegenerative disorders and aging

scientific article

Hormesis Mediates Dose-Sensitive Shifts in Macrophage Activation Patterns

scientific article published on 13 October 2018

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

scientific article published on 08 December 2020

Identification of retinal ganglion cells projecting to the lateral hypothalamic area of the rat ⬇️

scientific article published on October 3, 1997

Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat.

scientific article published on 11 April 2014

Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.

scientific article published on July 2017

Innervation of ventricular and periventricular brain compartments.

scientific article

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

scientific article published on 5 January 2016

Intracerebroventricular Delivery of Recombinant NAMPT Deters Inflammation and Protects Against Cerebral Ischemia

scientific article published on 28 February 2019

Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo.

scientific article published on 12 February 2016

Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey.

scientific article published in May 2013

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

scientific article published on 05 December 2019

Long weekend sleep is linked to stronger academic performance in male but not female pharmacy students

scientific article published on 01 September 2020

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury ⬇️

scientific article published on August 14, 2013

Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia.

scientific article published on 28 August 2012

Microglial and macrophage polarization—new prospects for brain repair

scientific article

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

scientific article published on November 2012

Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair

scientific article

N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.

scientific article published on 3 October 2013

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione

scientific article published on 22 August 2017

N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.

scientific article published on 18 December 2013

Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo

scientific article

Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles

scientific article

Neurobiology of stroke: Research progress and perspectives

scientific article published on 01 April 2018

Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury

scientific article

Neuroprotection against stroke and CNS injury: new mechanisms, targets, and controversies

scientific article published on 01 May 2013

Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.

scientific article

Neurotransmitter receptors on microglia

scientific article published on 24 June 2016

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.

scientific article published on January 2014

Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury.

scientific article published on 26 June 2013

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke

scientific article

Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury

scientific article published on 24 February 2016

Organization of suprachiasmatic nucleus projections in Syrian hamsters (Mesocricetus auratus): an anterograde and retrograde analysis.

scientific article published on January 2004

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

scientific article published on 8 November 2017

Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury.

scientific article published on 21 February 2013

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

scientific article published on 11 October 2017

Perspective for stroke and brain injury research: mechanisms and potential therapeutic targets

scientific article published in April 2015

Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates.

scientific article published on 02 September 2012

Physical activity-associated gene expression signature in nonhuman primate motor cortex.

scientific article published on 20 October 2011

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3

scientific journal article

Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

scientific article published on 02 January 2014

Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases

scientific article published on 2 January 2017

Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction.

scientific article published on 17 January 2018

Promises and limitations of immune cell-based therapies in neurological disorders

scientific article published on 01 September 2018

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

scientific article published on 17 April 2019

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

scientific article published on 13 November 2019

Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells.

scientific article published on January 2008

Rapid and sustained antidepressant properties of an NMDA antagonist/monoamine reuptake inhibitor identified via transporter-based virtual screening.

scientific article

Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury

scientific article published on 27 January 2016

Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders

scientific article

Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.

scientific article published on 22 May 2017

Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses

scientific article published on 19 September 2015

Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine ⬇️

scientific article published on June 9, 2012

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia.

scientific article

ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury

scientific article published on 7 April 2017

Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT.

scientific article

Splenic responses in ischemic stroke: new insights into stroke pathology.

scientific article

Stem cell therapies in age-related neurodegenerative diseases and stroke

scientific article published on 19 November 2016

Suprachiasmatic pacemaker organization analyzed by viral transynaptic transport.

scientific article

Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.

scientific article published on 2 March 2016

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia

scientific article published on 05 March 2019

Teaching Pharmacology Graduate Students how to Write an NIH Grant Application

scientific article

The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.

scientific article published on 30 June 2016

The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia

scientific article published on 10 June 2015

The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice

scientific article published on 10 April 2019

The dynamics of the mitochondrial organelle as a potential therapeutic target

scientific article

The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

scientific article

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

scientific article published on 21 June 2019

The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2

scientific journal article

The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

scientific article

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

scientific article published on 10 September 2018

Transgenic Overproduction of Omega-3 Polyunsaturated Fatty Acids Provides Neuroprotection and Enhances Endogenous Neurogenesis After Stroke ⬇️

scientific article published on November 1, 2013

Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury

scientific article published on 18 October 2018

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.

scientific article published on 13 January 2016

Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

scientific article

Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.

scientific article

Ventricular fibrillation cardiac arrest produces a chronic striatal hyperdopaminergic state that is worsened by methylphenidate treatment.

scientific article

Viability assays for cells in culture.

scientific article

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.

scientific article

n-3 PUFA supplementation benefits microglial responses to myelin pathology.

scientific article published on 12 December 2014

n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling.

scientific article

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