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List of works by Marianne Koritzinsky

A pilot 'window of opportunity' neoadjuvant study of metformin in localised prostate cancer.

scientific article published on 27 May 2014

AMPK regulates metabolism and survival in response to ionizing radiation

scientific article published on 27 June 2011

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

scientific article

Cell cycle progression and radiation survival following prolonged hypoxia and re-oxygenation.

scientific article published in March 2001

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance

scientific article published in January 2008

Contributions of AMPK and p53 dependent signaling to radiation response in the presence of metformin

scientific article published on 25 July 2013

Control of the hypoxic response through regulation of mRNA translation.

scientific article

Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment

scientific article

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

scientific article published on 12 June 2011

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

From Solo in the Silo to Strategic Training Programs

scientific article published on January 2016

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

scientific article

Hypoxia and Predicting Radiation Response

scientific article published on 15 May 2015

Hypoxia and regulation of messenger RNA translation

scientific article published on January 2007

Hypoxia as a target for combined modality treatments.

scientific article

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

scientific article

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells

scientific article

Hypoxia signaling and the metastatic phenotype

scientific article published on January 2014

Hypoxia signalling through mTOR and the unfolded protein response in cancer

scientific article published on 10 October 2008

Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response

scientific article published on 29 June 2009

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

scientific article published on April 2004

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

scientific article published on 17 September 2013

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

scientific article

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

scientific article published on 21 August 2015

Inhibition of 4E-BP1 sensitizes U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance

scientific article published in March 2009

Inverse dose-rate effect due to pre-mitotic accumulation during continuous low dose-rate irradiation of cervix carcinoma cells

scientific article published on 01 June 1999

Lack of inverse dose-rate effect and binding of the retinoblastoma gene product in the nucleus of human cancer T-47D cells arrested in G2 by ionizing radiation

scientific article published in June 2003

MATE2 Expression Is Associated with Cancer Cell Response to Metformin

scientific article

Measurement of Dose Rate at the Interface of Cell Culture Medium and Glass Dishes by Means of ESR Dosimetry Using Thin Films of Alanine

article

Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy

scientific article published on October 2015

Modulation of cell death in the tumor microenvironment

scientific article

Molecular targeting of hypoxia in radiotherapy

scientific article

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

scientific article published on 3 July 2013

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

scientific article published on 7 March 2013

Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies

scientific article published on 22 August 2006

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

scientific article published on 24 May 2007

Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours ⬇️

scientific article published on February 2014

Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress

article

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia

scientific article published on 17 May 2007

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

scientific article

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response

scientific article published on 18 October 2013

Survival of synchronized human NHIK 3025 cells irradiated aerobically following a prolonged treatment with extremely hypoxic conditions

scientific article published on 01 October 1998

Targeting the CXCL12/CXCR4 Pathway and Myeloid Cells to Improve Radiation Treatment of Locally Advanced Cervical Cancer.

scientific article published on 8 February 2018

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

scientific article

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

scientific article published on August 2005

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer

scientific article published on 16 February 2018

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

scientific article published in March 2008

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

scientific article published on 20 February 2012

The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia

scientific article published on October 2013

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

scientific article

Translational control is a major contributor to hypoxia induced gene expression

scientific article published on 28 June 2011

Translational control of gene expression during hypoxia

scientific article published on July 2006

Two phases of disulfide bond formation have differing requirements for oxygen.

scientific article

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