List of works - Alberto Bosque

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.

scientific article

An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription

scientific article

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

scientific article (publication date: 2013)

Apo2L/TRAIL and immune regulation.

scientific article published on January 2007

Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss

article

Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation

article

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.

scientific article

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.

scientific article published in January 2017

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes.

scientific article published on 15 May 2008

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.

scientific article published on 11 April 2016

Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.

scientific article published on 14 November 2012

Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr.

scientific article published on 22 January 2015

Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression.

scientific article published on 14 January 2005

Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells

scientific article published on 5 June 2014

Epigenetic regulation of HIV-1 latency by cytosine methylation

scientific article

Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients

scientific article

Fingolimod inhibits multiple stages of the HIV-1 life cycle

scientific article published on 13 August 2020

Generation of rabbit antibodies against death ligands by cDNA immunization

scientific article published on 02 October 2006

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

scientific article

HIV latency and integration site placement in five cell-based models.

scientific article published on 16 August 2013

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

scientific article published on 28 November 2019

HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response

scientific article published on 2 October 2009

HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins

scientific article published on 28 July 2015

Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells

scientific article

Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL

scientific article published on 01 June 2005

Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.

scientific article

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals

scientific article published on 30 November 2020

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

scientific article published on 10 October 2008

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

scientific article published on 20 December 2016

Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.

scientific article published on 23 October 2013

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

scientific article published on 22 January 2018

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

scientific article published on 9 May 2017

Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.

scientific article published on 14 July 2015

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro

scientific article published on 26 September 2017

Quantitative DY-maleimide-based proteomic 2-DE-labeling strategies using human skin proteins

scientific article published on 01 September 2009

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation

scientific article published on 24 October 2013

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

scientific article

Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL

scientific article published on 18 September 2006

Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.

scientific article

Structure activity relationship analysis of benzotriazine analogues as HIV-1 Latency Reversing Agents

scientific article published on 01 June 2020

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

scientific article published on 21 October 2010

Sulfonation pathway inhibitors block reactivation of latent HIV-1.

scientific article

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

scientific article published on 20 September 2017

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation

scientific article published in 2022

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling

scientific article published on 24 October 2006

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

scientific article

List of works by Alberto Bosque

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.

An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

Apo2L/TRAIL and immune regulation.

Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss

Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency.

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes.

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.

Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.

Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr.

Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression.

Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells

Epigenetic regulation of HIV-1 latency by cytosine methylation

Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients

Fingolimod inhibits multiple stages of the HIV-1 life cycle

Generation of rabbit antibodies against death ligands by cDNA immunization

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

HIV latency and integration site placement in five cell-based models.

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response

HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins

Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells

Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL

Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo

Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus.

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro

Quantitative DY-maleimide-based proteomic 2-DE-labeling strategies using human skin proteins

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL

Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.

Structure activity relationship analysis of benzotriazine analogues as HIV-1 Latency Reversing Agents

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

Sulfonation pathway inhibitors block reactivation of latent HIV-1.

T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.