List of works - Liliana Schaefer

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia

scientific article

A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival.

scientific article published on July 2005

A primer on iron therapy

scientific article published on 07 June 2007

Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload

scientific article

Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction

scientific article published on March 2002

Advances in Toll-like receptor biology: Modes of activation by diverse stimuli

scientific article published on 10 April 2015

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

scientific article

Analysis of Cell Type-Specific Effects of MicroRNA-92a Provides Novel Insights Into Target Regulation and Mechanism of Action

scientific article published on 01 November 2018

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

scientific article published on 22 December 2016

Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage

scientific article published on 04 January 2007

Between life and death: Epithelial cells in lung pathologies

scientific article published on 20 April 2020

Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis

scientific article published on 24 April 2014

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

scientific article published on 31 January 2019

Biglycan is a new high-affinity ligand for CD14 in macrophages

scientific article published on 17 May 2018

Biglycan is required for adaptive remodeling after myocardial infarction.

scientific article published on 25 February 2008

Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells ⬇️

scientific article published on April 27, 2003

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors

scientific article published on 15 July 2009

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

scientific article published on 15 December 2017

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

scientific article published on 09 March 2017

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury.

scientific article

Biglycan: a multivalent proteoglycan providing structure and signals

scientific article

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.

scientific article published on 12 December 2015

Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

scientific article published on 6 May 2008

Biological interplay between proteoglycans and their innate immune receptors in inflammation

scientific article

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy

scientific article published on 27 February 2019

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.

scientific article published in May 2009

Catabolism of newly synthesized decorin in vitro by human peritoneal mesothelial cells

scientific article

Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12.

scientific article published on 28 February 2017

Coagulation factor XII regulates inflammatory responses in human lungs.

scientific article published on 17 August 2017

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

scientific article published on 06 July 2020

Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs

scientific article

Complexity of danger: the diverse nature of damage-associated molecular patterns.

scientific article

Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys

scientific article published on 30 September 2020

Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development

scientific article published on 11 August 2019

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

scientific article published in November 2017

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

scientific article published on 18 December 2013

Decoding fibrosis: Mechanisms and translational aspects.

scientific article published on 18 April 2018

Decoding the Matrix: Instructive Roles of Proteoglycan Receptors

scientific article

Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells

scientific article

Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.

scientific article published on 22 December 2011

Decorin as a multivalent therapeutic agent against cancer.

scientific article published on 29 October 2015

Decorin causes autophagy in endothelial cells via Peg3

scientific article

Decorin deficiency leads to impaired angiogenesis in injured mouse cornea.

scientific article published on 28 October 2004

Decorin differentially modulates the activity of insulin receptor isoform A ligands.

scientific article

Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1.

scientific article published on 15 February 2013

Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy

scientific article

Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model

scientific article

Decorin, a novel player in the insulin-like growth factor system.

scientific article published on 8 February 2005

Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin

scientific journal article

Decorin: a guardian from the matrix

scientific article

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers

scientific article published on 27 October 2015

EphA2 is a functional receptor for the growth factor progranulin.

scientific article

Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis

scientific article

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

scientific article published on 04 January 2010

FXII promotes proteolytic processing of the LRP1 ectodomain.

scientific article published on 25 May 2017

Factor XII in coagulation, inflammation and beyond

scientific article published on 15 August 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

scientific article published on 24 August 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo

scientific article published on 5 March 2015

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface

scientific article

Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.

scientific article published on 7 June 2012

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells

scientific article published on 28 November 2016

In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer.

scientific article

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

scientific article published on 30 October 2015

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease

scientific article

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

scientific article

Instructive roles of extracellular matrix on autophagy.

scientific article published on 26 June 2014

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

scientific article published on 19 July 2020

KIBRA modulates directional migration of podocytes

scientific article

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

scientific article

LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension

scientific article published on 22 March 2019

LRP1: A chameleon receptor of lung inflammation and repair.

scientific article published on 17 December 2017

Lipids - two sides of the same coin in lung fibrosis

scientific article published on 15 April 2019

Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.

scientific article published on 31 March 2016

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

scientific article published on 11 December 2019

Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation

scientific article published on 7 November 2017

Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506

scientific journal article

Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats

scholarly article by Liliana Schaefer published in November 2004

Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.

scientific article published on October 2011

Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1.

scientific article

Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis

scientific article

Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis

scientific article published on 4 May 2005

Oncosuppressive functions of decorin

scientific article published on 25 February 2015

OxLDL inhibits LPS-induced IFNβ expression by Pellino3- and IRAK1/4-dependent modification of TANK.

scientific article

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors

scientific article published in February 2017

Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system

scientific article published on 03 November 2019

Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism

scientific article published on August 2012

Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

scientific article published on 24 July 2020

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus

scientific article published on 01 October 2018

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

scientific article published in March 2018

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

scientific article

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.

scientific article published on 17 November 2016

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans ⬇️

scientific article published on August 31, 2010

Proteoglycans, key regulators of cell-matrix dynamics

scientific article

Proteoglycans: from structural compounds to signaling molecules

scientific article published on 10 June 2009

Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.

scientific article published on 28 December 2009

Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury ⬇️

scientific article

Renal Fibrosis: Common Enemy of Many Origins

scientific article published on 01 September 2019

Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy.

scientific article

Reply

Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells

scientific article published on 12 April 2014

Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice

scientific article

Role of Nox4 in murine models of kidney disease.

scientific article published on 27 June 2012

Role of fibrillin-1 in hypertensive and diabetic glomerular disease

scientific article published on 27 December 2005

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

scientific article

Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling.

scientific article published on 16 May 2017

Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21

scientific article

Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin

scientific article published in October 2017

Small leucine-rich proteoglycans in kidney disease.

scientific article published on 30 June 2011

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation.

scientific article

Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation

scientific article published on 09 February 2012

Soluble biglycan as a biomarker of inflammatory renal diseases

scientific article

Special issue: Extracellular matrix: Therapeutic tools and targets in cancer treatment

scientific article published on 01 February 2016

Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction

scientific article published on 11 August 2017

Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions.

scientific article published on 29 March 2018

Targeting GLI Transcription Factors in Cancer.

scientific article published on 24 April 2018

Targeting renal fibrosis: Mechanisms and drug delivery systems.

scientific article published on 26 December 2017

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

scientific article published on 07 July 2020

The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

scientific article published on July 2005

The matricellular functions of small leucine-rich proteoglycans (SLRPs).

scientific article published on 2 October 2009

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

scientific article

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

scientific article published on 04 February 2020

The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis

scientific article

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

scientific article

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis

scientific article published on 22 November 2018

Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

scientific article

Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry.

scientific article published on 14 March 2013

Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice.

scientific article published on 12 July 2007

Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis

scientific article published on 07 December 2020

WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

scientific article

WWC proteins regulate hepatic cell differentiation and tumorigenesis via the Hippo signaling pathway.

scientific article published on 8 November 2017

List of works by Liliana Schaefer

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia

A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organisation and cell survival.

A primer on iron therapy

Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload

Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction

Advances in Toll-like receptor biology: Modes of activation by diverse stimuli

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

Analysis of Cell Type-Specific Effects of MicroRNA-92a Provides Novel Insights Into Target Regulation and Mechanism of Action

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage

Between life and death: Epithelial cells in lung pathologies

Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

Biglycan is a new high-affinity ligand for CD14 in macrophages

Biglycan is required for adaptive remodeling after myocardial infarction.

Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells ⬇️

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury.

Biglycan: a multivalent proteoglycan providing structure and signals

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.

Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

Biological interplay between proteoglycans and their innate immune receptors in inflammation

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.

Catabolism of newly synthesized decorin in vitro by human peritoneal mesothelial cells

Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12.

Coagulation factor XII regulates inflammatory responses in human lungs.

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs

Complexity of danger: the diverse nature of damage-associated molecular patterns.

Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys

Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

Decoding fibrosis: Mechanisms and translational aspects.

Decoding the Matrix: Instructive Roles of Proteoglycan Receptors

Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells

Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.

Decorin as a multivalent therapeutic agent against cancer.

Decorin causes autophagy in endothelial cells via Peg3

Decorin deficiency leads to impaired angiogenesis in injured mouse cornea.

Decorin differentially modulates the activity of insulin receptor isoform A ligands.

Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1.

Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy

Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model

Decorin, a novel player in the insulin-like growth factor system.

Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin

Decorin: a guardian from the matrix

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers

EphA2 is a functional receptor for the growth factor progranulin.

Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

FXII promotes proteolytic processing of the LRP1 ectodomain.

Factor XII in coagulation, inflammation and beyond

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface

Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4.

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells

In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer.

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Instructive roles of extracellular matrix on autophagy.

Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?

KIBRA modulates directional migration of podocytes

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension

LRP1: A chameleon receptor of lung inflammation and repair.

Lipids - two sides of the same coin in lung fibrosis

Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation

Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506

Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats

Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.