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List of works by Paul Williams

2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis

4-quinolone signalling in Pseudomonas aeruginosa: old molecules, new perspectives.

scientific article

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus

scientific article

A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

scientific article

A cell-cell communication signal integrates quorum sensing and stress response

scientific article published on March 31, 2013

A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules.

scientific article published in November 2007

A mathematical investigation of the effects of inhibitor therapy on three putative phosphorylation cascades governing the two-component system of the agr operon

scientific article published on 7 March 2010

A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: quorum sensing and the build-up to invasion.

scientific article

A method for the enumeration of bacterial adhesion to epithelial cells using image analysis

scientific article published on 01 February 1993

Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin

scientific article published on 30 November 2021

Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression

scientific article

Affinity, conservation, and surface exposure of hemopexin-binding proteins in Haemophilus influenzae.

scientific article

Analysis of bacterial carbapenem antibiotic production genes reveals a novel β-lactam biosynthesis pathway.

scientific article

Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.

scientific article

Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.

scientific article published on 22 January 2013

Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactone

scientific article published on 01 March 1993

Bacillus subtilis: a shocking message from a probiotic

scientific article published on 01 June 2007

Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity

scientific article

Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch!

scientific article

Bacterial conversations: talking, listening and eavesdropping. An introduction

scientific article published on July 2007

Bacterial transferrin receptors ? structure, function and contribution to virulence

scientific article published on January 1, 1992

Biofilm development on Caenorhabditis elegans by Yersinia is facilitated by quorum sensing-dependent repression of type III secretion

scientific article

Biofilm formation in Pseudomonas aeruginosa: fimbrial cup gene clusters are controlled by the transcriptional regulator MvaT

scientific journal article

Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules.

scientific article published in January 2007

Biosensors for qualitative and semiquantitative analysis of quorum sensing signal molecules.

scientific article published in January 2014

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

scientific article published on 25 March 2015

Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence

scientific article published on 30 November 2015

Bursting the bubble on bacterial biofilms: a flow cell methodology

scientific article published on January 2012

Cell envelope proteins of Staphylococcus epidermidis grown in vivo in a peritoneal chamber implant.

scientific article published on June 1992

Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover.

scholarly article

Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia.

scientific article

Characterization of cell envelope proteins of Staphylococcus epidermidis cultured in human peritoneal dialysate.

scientific article published on February 1991

Chitinolytic activity in Chromobacterium violaceum: substrate analysis and regulation by quorum sensing.

scientific article published on September 1998

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

scientific article

Combinatorial discovery of polymers resistant to bacterial attachment

scientific article published on September 2012

Common antigenic domains in transferrin-binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae type b

scientific article published on June 1992

Compromising bacterial communication skills.

scientific article published on April 1994

Conflict of interest and signal interference lead to the breakdown of honest signaling

scientific article published on 18 August 2015

Conservation, surface exposure, and in vivo expression of the Frp family of iron-regulated cell wall proteins in Staphylococcus aureus.

scientific article published on May 2002

Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing.

scientific article

Continuous ambulatory peritoneal dialysis-associated peritonitis as a model device-related infection: phenotypic adaptation, the staphylococcal cell envelope and infection

scientific article published in June 1995

Cross-strain quorum sensing inhibition by Staphylococcus aureus. Part 1: A spatially homogeneous model

scientific article published on 23 November 2011

Cross-strain quorum sensing inhibition by Staphylococcus aureus. Part 2: A spatially inhomogeneous model

scientific article published on 23 November 2011

Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones

scientific article published on 27 July 2016

Detection of 2-Alkyl-4-Quinolones Using Biosensors

scientific article published in January 2018

Detection of Agr-Type Autoinducing Peptides Produced by Staphylococcus aureus

scientific article published in January 2018

Deterministic and stochastic modelling of endosome escape by Staphylococcus aureus: "quorum" sensing by a single bacterium.

scientific article published on 11 November 2004

Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating

scientific article published on 23 May 2017

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: A longitudinal study

scientific article published on 20 October 2016

Differential immune modulatory activity of Pseudomonas aeruginosa quorum-sensing signal molecules.

scientific article published on November 2004

Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

scientific article published in December 2009

Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum.

scientific article published in January 2002

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays

scientific article published on 18 February 2013

Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo

scientific article published on 01 September 2019

Effects of carbon dioxide and sub-lethal levels of antibiotics on adherence of coagulase-negative staphylococci to polystyrene and silicone rubber

scientific article published on 01 May 1991

Electrostatic sensor for identifying interactions between peptides and bacterial membranes.

scientific article published on November 2003

Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment

scientific article

Engineering theluxCDABEgenes fromPhotorhabdus luminescensto provide a bioluminescent reporter for constitutive and promoter probe plasmids and mini-Tn5constructs

scientific article published in June 1998

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production.

scientific article published in April 2017

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

scientific article published on 18 July 2018

Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b

scientific article published on July 1, 1992

Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing

scientific article published on April 2006

Functional analysis of the post-transcriptional regulator RsmA reveals a novel RNA-binding site.

scientific article

Functional complementation of E. coli secD and secG mutants by Helicobacter pylori homologues.

scientific article

Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.

scientific article published in April 2010

Gaussia Luciferase as a Reporter for Quorum Sensing in Staphylococcus aureus

scientific article published on 01 August 2020

Genome Sequences of Two Pandoraea pnomenusa Isolates Recovered 11 Months Apart from a Cystic Fibrosis Patient.

scientific article published on 5 February 2015

Genome sequencing-assisted identification and the first functional validation of N-acyl-homoserine-lactone synthases from the Sphingomonadaceae family.

scientific article published on 30 August 2016

Genome-wide evaluation of the interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during in vivo biofilm formation

scientific article

Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN

scientific article published on 01 July 2018

Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.

scientific article published on 20 November 2009

Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori.

scientific article published in January 2004

Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to Pseudomonas aeruginosa infection.

scientific article

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry

scientific article

High throughput methods applied in biomaterial development and discovery

scientific article published on 07 October 2009

High-Throughput Screening of Inhibitors TargetingAgr/FsrQuorum Sensing inStaphylococcus aureusandEnterococcus faecalis

scientific article published on May 7, 2013

HosA, a member of the SlyA family, regulates motility in enteropathogenic Escherichia coli.

scientific article published on March 2005

Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres

scientific article published on January 1, 1992

Identification of a quorum-sensing signal molecule in the facultative intracellular pathogen Brucella melitensis

scientific article

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

scientific article published on 28 April 2020

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone

scientific article published on 13 April 2011

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

scientific article published on 28 January 2018

In vitro biosynthesis of the Pseudomonas aeruginosa quorum-sensing signal molecule N-butanoyl-L-homoserine lactone

scientific article published on 01 April 1998

In vivo evaluation of protein adsorption to sterically stabilised colloidal carriers

scientific article published on 01 July 1993

Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase

scientific article published on 01 February 2011

Influence of block copolymers on the adsorption of plasma proteins to microspheres.

scientific article

Influence of carbon dioxide on growth and antibiotic susceptibility of coagulase-negative staphylococci cultured in human peritoneal dialysate.

scientific article published on October 1990

Influence of lipopolysaccharide chemotype on the interaction between Klebsiella pneumoniae and human polymorphonuclear leucocytes

scientific article published on 01 June 1990

Integrated whole-genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific.

scientific article published on 3 April 2015

Interkingdom crosstalk: host neuroendocrine stress hormones drive the hemolytic behavior of Salmonella typhi.

scientific article published on July 2011

Irreversible inactivation of beta-lactamase I from Bacillus cereus by chlorinated 6-spiroepoxypenicillins.

scientific article published on June 1991

Isolation and characterisation of Haemophilus influenzae type b mutants defective in transferrin-binding and iron assimilation

scientific article published on 01 January 1991

LC-MS/MS quantitative analysis of quorum sensing signal molecules.

scientific article published in January 2014

Look who's talking: communication and quorum sensing in the bacterial world.

scientific article published on July 2007

LuxS and autoinducer-2: their contribution to quorum sensing and metabolism in bacteria.

scientific article published on January 2003

LuxS-based quorum sensing does not affect the ability of Salmonella enterica serovar Typhimurium to express the SPI-1 type 3 secretion system, induce membrane ruffles, or invade epithelial cells

scientific article published on 25 September 2009

LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence.

scientific article published in March 2002

LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone.

scientific article

Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting

scientific article published on 24 October 2016

Mathematical modelling of quorum sensing in bacteria.

scientific article published in September 2001

Mathematical modelling of the agr operon in Staphylococcus aureus

scientific article published on 18 August 2009

Mathematical modelling of therapies targeted at bacterial quorum sensing.

scientific article published in November 2004

Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system.

scientific article published in February 2012

Modelling host tissue degradation by extracellular bacterial pathogens.

scientific article published in September 2003

Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter.

scientific article

N-(3-oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora

scientific article published on December 15, 1992

N-acyl-homoserine lactone-mediated regulation of phenazine gene expression by Pseudomonas aureofaciens 30-84 in the wheat rhizosphere

scientific article published on December 1997

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.

scientific article published in February 2006

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

scientific article published on October 2002

Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum.

scientific article published on 07 March 2017

Particulate air pollution impacts directly on bacterial pathogen behaviour and infection.

scientific article published on 29 May 2017

Pathogen espionage: multiple bacterial adrenergic sensors eavesdrop on host communication systems

scientific article published on December 11, 2012

Penetration of immunoglobulins through the Klebsiella capsule and their effect on cell-surface hydrophobicity

scientific article published on 01 May 1988

Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa

scientific article

Polymer microarrays for high throughput discovery of biomaterials

scientific article

Predicting the virulence of MRSA from its genome sequence

scientific article

Prediction of Broad-spectrum Pathogen Attachment to Coating Materials for Biomedical Devices.

scientific article published in December 2017

Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients.

scientific article published in May 2003

Professor Dieter Haas (1945-2017)

scientific article published on 14 August 2017

Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

scientific article

Quantitative liquid chromatography-tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli.

scientific article published on 22 April 2010

Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.

scientific article

Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones

scientific article published on 01 December 1997

Quorum sensing and social networking in the microbial world.

scientific article published on 12 August 2009

Quorum sensing and the lifestyle of Yersinia.

scientific article published on January 2006

Quorum sensing as a population-density-dependent determinant of bacterial physiology.

scientific article

Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria.

scientific article

Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules

scientific article published on September 1, 1997

Quorum sensing in Clostridium difficile: analysis of a luxS-type signalling system.

scientific article published in February 2005

Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility

scientific article

Quorum sensing, communication and cross-kingdom signalling in the bacterial world.

scientific article published in December 2007

Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila

scientific article published on October 1999

Quorum sensing: a novel target for anti-infective therapy

scientific article published on 01 November 1998

Quorum sensing: a population-density component in the determination of bacterial phenotype.

scientific article published in June 1996

Quorum-sensing and cheating in bacterial biofilms

scientific article

Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria

article

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections

scientific article published on 22 January 2020

Real-time monitoring of intracellular Staphylococcus aureus replication

scientific article

Receptor-Mediated Recognition and Uptake of Iron from Human Transferrin by Staphylococcus aureus and Staphylococcus epidermidis

scientific article published on August 1, 1998

Regulation of the xcp secretion pathway by multiple quorum‐sensing modulons in Pseudomonas aeruginosa

scientific article published on June 1, 1997

Role of the cell envelope in bacterial adaptation to growth in vivo in infections.

scientific article published on August 1988

Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E

scientific article

Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.

scientific article

Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis

scientific article published in December 2008

Simultaneous Tracking of Pseudomonas aeruginosa Motility in Liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators

scientific article published on 24 September 2019

Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS

scientific article published on 28 October 2010

SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis

scientific article published on September 1, 1998

Small molecule mediated autoinduction of antibiotic biosynthesis in the plant pathogen Erwinia carotovora

scientific article published on 01 February 1995

Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics

scientific article published in December 1992

Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein.

scientific article published on September 1994

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

scientific article

Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus.

scientific article published in July 2001

Surface exposure of O1 serotype lipopolysaccharide in Klebsiella pneumoniae strains expressing different K antigens

scientific article published on June 1991

Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors

scientific article

The Aeromonas hydrophila LuxR homologue AhyR regulates the N-acyl homoserine lactone synthase, AhyI positively and negatively in a growth phase-dependent manner

scientific article published in December 2004

The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of N-(3-hydroxyhexanoyl)homoserine lactone and N-hexanoylhomoserine lactone.

scientific article

The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment.

scientific article published in January 2007

The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity

scientific article published in January 1998

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c‐di‐GMP signalling

scientific article published on September 29, 2011

The Rap and Hor proteins of Erwinia, Serratia and Yersinia: a novel subgroup in a growing superfamily of proteins regulating diverse physiological processes in bacterial pathogens

scientific article published on November 1, 1997

The Role of the O and K Antigens in Determining the Resistance of Klebsiella aerogenes to Serum Killing and Phagocytosis

scientific article published on July 1, 1983

The RssAB two-component signal transduction system in Serratia marcescens regulates swarming motility and cell envelope architecture in response to exogenous saturated fatty acids

scientific article

The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection

scientific article published on 01 April 1998

The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.

scientific article published on 30 March 2010

The art of antibacterial warfare: Deception through interference with quorum sensing-mediated communication.

scientific article published on 21 April 2014

The fitness burden imposed by synthesising quorum sensing signals.

scientific article

The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa

scientific journal article

The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa

scientific journal article

The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system

scientific article published on November 2002

The inner workings of a quorum sensing signal generator

scientific article published in December 1996

The interaction of N-acylhomoserine lactone quorum sensing signaling molecules with biological membranes: implications for inter-kingdom signaling

scientific article

The regulation of biofilm development by quorum sensing in Aeromonas hydrophila

scientific article published in January 2002

The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

scientific article

Thermally switchable polymers achieve controlled Escherichia coli detachment

scientific article

Timing Is Everything: Impact of Naturally Occurring Staphylococcus aureus AgrC Cytoplasmic Domain Adaptive Mutations on Autoinduction

scientific article published on 20 September 2019

Tn916 insertion mutagenesis in Escherichia coli and Haemophilus influenzae type b following conjugative transfer

scientific article published on 01 March 1992

To Boil an Egg: Substrate Binding Affects Critical Stability in Thermal Unfolding of Proteins.

scientific article published on 5 February 2018

Topoisomerase II: a potential target for novel antifungal agents

scientific article published on 01 April 1989

Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa

scientific article

Utilization of enterobactin and other exogenous iron sources by Haemophilus influenzae, H. parainfluenzae and H. paraphrophilus

scientific article published on 01 December 1990

Variation in the expression of cell envelope proteins of coagulase-negative staphylococci cultured under iron-restricted conditions in human peritoneal dialysate

scientific article published on 01 November 1991

Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors.

scientific article published in September 2004

Water contact angle is not a good predictor of biological responses to materials

scientific article published on 6 July 2017

Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis.

scientific article

Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming

scientific article published on 25 March 2022

Yersinia virulence factors - a sophisticated arsenal for combating host defences

scientific article

[(18)F]FDG-6-P as a novel in vivo tool for imaging staphylococcal infections.

scientific article

agr expression precedes escape of internalized Staphylococcus aureus from the host endosome

scientific article