List of works by Domenico Spina

A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects

scientific article published on 01 January 2000

A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways

scientific article published on 01 January 1998

A comparison of the pharmacological modulation of hyperalgesia and bronchial hyperresponsiveness.

scientific article

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

article

A novel animal model for investigating persistent airway hyperresponsiveness

scientific article published on 01 December 1993

A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

scientific article published on 27 January 2014

Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

scientific article published on 12 March 2014

Adenosine receptors and asthma

scientific article published on 01 January 2009

Adenosine receptors and asthma.

scientific article

Airway irritability--a burning issue?

scientific article published on 20 July 2009

Airway nerves and protein phosphatases.

scientific article

Airway nerves: neurotransmitter release.

scientific article

Airway responsiveness in an allergic rabbit model

scientific article published on 11 August 2011

Airway sensory nerves in asthma--targets for therapy?

scientific article published on February 1996

Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M(2)-receptor dysfunction

scientific article published on 01 January 1999

Asthma -- a need for a rethink?

scientific article

Bronchial hyperresponsiveness induced by chronic treatment with albuterol: Role of sensory nerves.

scientific article

Bronchial hyperresponsiveness: a rather irritable subject

scientific article published on 04 November 2009

Current and novel bronchodilators in respiratory disease

scientific article published on January 2014

Cytokines in airway inflammation.

scientific article

Dose-related effects of formoterol on airway responsiveness to adenosine 5'-monophosphate and histamine.

scientific article

Editorial overview: Respiratory: Cough: a burning issue.

scientific article published on 23 May 2015

Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.

scientific article

Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects

scientific article published in July 1998

Effect of the Mixed Phosphodiesterase 3/4 Inhibitor RPL554 on Human Isolated Bronchial Smooth Muscle Tone

scientific article published on 13 June 2013

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

scientific article published on 25 October 2013

Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.

scientific article published on 24 October 2007

Experimental design and analysis and their reporting: new guidance for publication in BJP.

scientific article published on July 2015

Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity

scientific article

Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?

scientific article published on 8 June 2007

Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system

scientific article published on 12 June 2006

Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized Guinea pigs

scientific article published on 27 May 2008

Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system.

scientific article published in January 2005

In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery

scientific article

Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.

scientific article published in April 2006

Modulation of sensory nerve function in the airways

scientific article published on 01 November 1998

Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation

scientific article published on 23 March 2012

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock

scientific article

Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.

scientific article published on 02 February 2016

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

scientific article published on 23 December 2014

Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.

scientific article published on January 2009

Phosphodiesterase inhibitors in the treatment of inflammatory diseases.

scientific article published on January 2011

Phosphodiesterase inhibitors.

scientific article

Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.

scientific article published on January 2003

Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation

scientific article published on 04 November 2004

Platelets are essential for leukocyte recruitment in allergic inflammation.

scientific article published in July 2003

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

scientific article

Protease inhibitors in respiratory disease: focus on asthma and chronic obstructive pulmonary disease.

scientific article published in May 2007

Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis.

scientific article

Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility

scientific article published on 19 March 2014

Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits.

scientific article

Selective PDE inhibitors as novel treatments for respiratory diseases.

scientific article published on 11 April 2012

Sensory nerves and airway irritability.

scientific article published on January 2009

Special issue of BJP on respiratory pharmacology.

scientific article published on May 2011

Sublingual absorption of salbutamol in the guinea-pig

scientific article published on 01 January 1997

The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.

scientific article published on 5 February 2015

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

scientific article

The potential of PDE4 inhibitors in respiratory disease

scientific article published in September 2004

The rabbit as an experimental and production animal: from genomics to proteomics

scientific article published on March 2014

The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice

scientific article published on 01 May 2000

The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus

scientific article published on 3 June 2015

The role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in the guinea-pig

scientific article published on 01 January 1999

The use of bronchodilators in stable chronic obstructive pulmonary disease.

scientific article published on June 1997

Theophylline and PDE4 inhibitors in asthma.

scientific article

Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs.

scientific article published in March 2010

What have transgenic and knockout animals taught us about respiratory disease?

scientific article

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