List of works - Stephen Man

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

scientific article published on 22 June 2011

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer.

scientific article published in June 1996

Activated B cells mediate efficient expansion of rare antigen-specific T cells

scientific article published on 08 January 2007

Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial

scientific article published on 7 October 2014

Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice

scientific article published on 01 April 2002

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

scientific article

CD8(+) T-cell recognition of a synthetic epitope formed by t-butyl modification

scientific article

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

scientific article published on 27 September 2016

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

scientific article published on October 2005

Chronic lymphocytic leukaemia: the role of T cells in a B cell disease

scientific article published on 03 April 2019

Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer.

scientific article

Cross-typic specificity and immunotherapeutic potential of a human HPV16 E7-specific CTL line.

scientific article

Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia

scientific article published on 28 April 2016

Cytotoxic T cells head for the clinic? ⬇️

scientific article published on 01 August 1997

Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy

scientific article

Definition of an HPV18/45 cross-reactive human T-cell epitope after DNA immunisation of HLA-A2/KB transgenic mice

scientific article published on 01 May 2006

Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R).

scientific article

Epitope specificity and longevity of a vaccine-induced human T cell response against HPV18.

scientific article published on 27 December 2004

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.

scientific article

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

scientific article published on 20 March 2012

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

scientific article

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells.

scientific article published on November 2010

HPV16 E6 29-38-specific T cells kill cervical carcinoma cells despite partial evasion of T-cell effector function.

scientific article

Human cancer vaccines

scientific article published on 17 August 2006

Human cellular immune responses against human papillomaviruses in cervical neoplasia.

scientific article published on 3 July 1998

Identification of HLA-DR1- and HLA-DR15-restricted human papillomavirus type 16 (HPV16) and HPV18 E6 epitopes recognized by CD4+ T cells from healthy young women.

scientific article published on May 2007

Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination

scientific article published in May 2004

Immunology of human papillomavirus infection in lower genital tract neoplasia.

scientific article

Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

scientific article published on 20 March 2012

Increased frequency of CD4+ PD-1+ HLA-DR+ T cells is associated with disease progression in CLL

scientific article published on 08 November 2019

Individual variation in the frequency of HLA class II-specific cytotoxic T lymphocyte precursors.

scientific article published on April 1990

Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification.

scientific article published in January 2010

Role of endogenous peptide in human alloreactive cytotoxic T cell responses

scientific article published on March 1, 1992

Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus

scientific article published in PLoS ONE

Systemic listeriosis following vaccination with the attenuated Listeria monocytogenes therapeutic vaccine, ADXS11-001

scholarly article by Joseph J Sacco et al published 2 April 2016 in Human Vaccines & Immunotherapeutics

T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells.

scientific article published on 23 December 2005

T-cell response to human papillomavirus type 52 L1, E6, and E7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer

scientific article published on 01 June 2011

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse

scientific article published on 09 March 2015

The nature of telomere fusion and a definition of the critical telomere length in human cells

scientific article

The use of human leucocyte antigen class I transgenic mice to investigate human immune function

scientific article published on 01 December 1998

Use of an anti-CD200-blocking antibody improves immune responses to AML in vitro and in vivo

scientific article published on 30 September 2020

List of works by Stephen Man

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer.

Activated B cells mediate efficient expansion of rare antigen-specific T cells

Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial

Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

CD8(+) T-cell recognition of a synthetic epitope formed by t-butyl modification

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

Chronic lymphocytic leukaemia: the role of T cells in a B cell disease

Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer.

Cross-typic specificity and immunotherapeutic potential of a human HPV16 E7-specific CTL line.

Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia

Cytotoxic T cells head for the clinic? ⬇️

Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy

Definition of an HPV18/45 cross-reactive human T-cell epitope after DNA immunisation of HLA-A2/KB transgenic mice

Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R).

Epitope specificity and longevity of a vaccine-induced human T cell response against HPV18.

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells.

HPV16 E6 29-38-specific T cells kill cervical carcinoma cells despite partial evasion of T-cell effector function.

Human cancer vaccines

Human cellular immune responses against human papillomaviruses in cervical neoplasia.

Identification of HLA-DR1- and HLA-DR15-restricted human papillomavirus type 16 (HPV16) and HPV18 E6 epitopes recognized by CD4+ T cells from healthy young women.

Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination

Immunology of human papillomavirus infection in lower genital tract neoplasia.

Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

Increased frequency of CD4+ PD-1+ HLA-DR+ T cells is associated with disease progression in CLL

Individual variation in the frequency of HLA class II-specific cytotoxic T lymphocyte precursors.

Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification.

Role of endogenous peptide in human alloreactive cytotoxic T cell responses

Sensitivity to inhibition of DNA repair by Olaparib in novel oropharyngeal cancer cell lines infected with Human Papillomavirus

Systemic listeriosis following vaccination with the attenuated Listeria monocytogenes therapeutic vaccine, ADXS11-001

T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells.

T-cell response to human papillomavirus type 52 L1, E6, and E7 peptides in women with transient infection, cervical intraepithelial neoplasia, and invasive cancer

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse

The nature of telomere fusion and a definition of the critical telomere length in human cells

The use of human leucocyte antigen class I transgenic mice to investigate human immune function

Use of an anti-CD200-blocking antibody improves immune responses to AML in vitro and in vivo