List of works - Maurizio Federico

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

scientific article published on July 2009

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

article

Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.

scientific article

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

scientific article

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

article

In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r

scientific article published on 20 December 2006

Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes

scientific article

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1.

scientific article

HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis

article

Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1.

scientific article

Virological consequences of early events following cell-cell contact between human immunodeficiency virus type 1-infected and uninfected CD4+ cells

scientific article published on 28 May 2008

cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.

scientific article published on January 2000

T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.

scientific article

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity

scientific article

A strategy of antigen incorporation into exosomes: comparing cross-presentation levels of antigens delivered by engineered exosomes and by lentiviral virus-like particles.

scientific article published on 22 October 2012

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis.

scientific article published on 14 June 2016

Inhibition of HIV-1 replication in monocyte-derived macrophages by Mycobacterium tuberculosis

scientific article published on 4 February 2004

HIV-1 Nef regulates the release of superoxide anions from human macrophages.

scientific article published on September 2005

Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.

scientific article published on 11 June 2012

Cell death induced by the herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles.

scientific article published on 10 August 2005

Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein.

scientific article published on 2 October 2009

Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFα in macrophages.

scientific article

Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.

scientific article

Macrophages transmit human immunodeficiency virus type 1 products to CD4-negative cells: involvement of matrix metalloproteinase 9.

scientific article

HPV-E7 delivered by engineered exosomes elicits a protective CD8⁺ T cell-mediated immune response

scientific article

Homologous superinfection of both producer and nonproducer HIV-infected cells is blocked at a late retrotranscription step.

scientific article

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

scientific article

Lentivirus-Based Virus-Like Particles as a New Protein Delivery Tool

scientific article published on January 1, 2010

Recovery of HIV-related retroviruses from Italian patients with AIDS or AIDS-related complex and from asymptomatic at-risk individuals.

scientific article published in January 1987

Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way.

scientific article

T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner.

scientific article

AN EXOSOME-BASED VACCINE PLATFORM IMPARTS CYTOTOXIC T LYMPHOCYTE IMMUNITY AGAINST VIRAL ANTIGENS.

scientific article published on 23 December 2017

Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles.

scientific article published on 4 November 2005

HIV-1 Nef induces p47(phox) phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line.

scientific article

Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner

scientific article published on September 2014

miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes

scientific article

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation

scientific article published on 23 June 2017

The Multifaceted Functions of Exosomes in Health and Disease: An Overview.

scientific article published on January 2017

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells

scientific article published in August 2003

Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages

scientific article published on 24 October 2006

DC contact with HIV-1-infected cells leads to high levels of Env-mediated virion endocytosis coupled with enhanced HIV-1 Ag presentation

scientific article

A recombinant retrovirus carrying a non-producer human immunodeficiency virus (HIV) type 1 variant induces resistance to superinfecting HIV.

scientific article published in October 1993

Full expression of transfected nonproducer interfering HIV-1 proviral DNAabrogates susceptibility of human He-La CD4+ cells to HIV

article

Strong CD8+ T cell antigenicity and immunogenicity of large foreign proteins incorporated in HIV-1 VLPs able to induce a Nef-dependent activation/maturation of dendritic cells

article

Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: role of CD4 down-modulation

scientific article published on November 2000

Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend leukemia cells. V. Comparisons with the action of tumor necrosis factor

scientific article published on 01 November 1986

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells

scientific article

Engineered exosomes emerging from muscle cells break immune tolerance to HER2 in transgenic mice and induce antigen-specific CTLs upon challenge by human dendritic cells

scientific article published on 27 December 2017

HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step

scientific article published on May 28, 2011

The ADAR1 editing enzyme is encapsidated into HIV-1 virions

scientific article published on 9 September 2015

List of works by Maurizio Federico

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r

Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1.

HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis

Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1.

Virological consequences of early events following cell-cell contact between human immunodeficiency virus type 1-infected and uninfected CD4+ cells

cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.

T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity

A strategy of antigen incorporation into exosomes: comparing cross-presentation levels of antigens delivered by engineered exosomes and by lentiviral virus-like particles.

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis.

Inhibition of HIV-1 replication in monocyte-derived macrophages by Mycobacterium tuberculosis

HIV-1 Nef regulates the release of superoxide anions from human macrophages.

Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.

Cell death induced by the herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles.

Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein.

Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFα in macrophages.

Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.

Macrophages transmit human immunodeficiency virus type 1 products to CD4-negative cells: involvement of matrix metalloproteinase 9.

HPV-E7 delivered by engineered exosomes elicits a protective CD8⁺ T cell-mediated immune response

Homologous superinfection of both producer and nonproducer HIV-infected cells is blocked at a late retrotranscription step.

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

Lentivirus-Based Virus-Like Particles as a New Protein Delivery Tool

Recovery of HIV-related retroviruses from Italian patients with AIDS or AIDS-related complex and from asymptomatic at-risk individuals.

Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way.

T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner.

AN EXOSOME-BASED VACCINE PLATFORM IMPARTS CYTOTOXIC T LYMPHOCYTE IMMUNITY AGAINST VIRAL ANTIGENS.

Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles.

HIV-1 Nef induces p47(phox) phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line.

Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner

miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation

The Multifaceted Functions of Exosomes in Health and Disease: An Overview.

Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells

Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages

DC contact with HIV-1-infected cells leads to high levels of Env-mediated virion endocytosis coupled with enhanced HIV-1 Ag presentation

A recombinant retrovirus carrying a non-producer human immunodeficiency virus (HIV) type 1 variant induces resistance to superinfecting HIV.

Full expression of transfected nonproducer interfering HIV-1 proviral DNAabrogates susceptibility of human He-La CD4+ cells to HIV

Strong CD8+ T cell antigenicity and immunogenicity of large foreign proteins incorporated in HIV-1 VLPs able to induce a Nef-dependent activation/maturation of dendritic cells

Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: role of CD4 down-modulation

Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend leukemia cells. V. Comparisons with the action of tumor necrosis factor

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells

Engineered exosomes emerging from muscle cells break immune tolerance to HER2 in transgenic mice and induce antigen-specific CTLs upon challenge by human dendritic cells

HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step

The ADAR1 editing enzyme is encapsidated into HIV-1 virions