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List of works by Jan C Koch

AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury

scientific article published on 13 April 2015

AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo

scientific article published on 26 February 2021

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

scientific article published on 2 October 2014

Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner

scientific article published on July 2010

Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.

scientific article

Alpha-synuclein and iron: two keys unlocking Parkinson's disease.

scientific article published on 6 February 2017

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.

scientific article published on 10 September 2014

Attenuation of Axonal Degeneration by Calcium Channel Inhibitors Improves Retinal Ganglion Cell Survival and Regeneration After Optic Nerve Crush.

scientific article published on 5 January 2016

Axonal degeneration as a therapeutic target in the CNS.

scientific article published on 06 March 2012

Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration

scientific article

Clinical testing and spinal cord removal in a mouse model for amyotrophic lateral sclerosis (ALS)

scientific article published on 17 March 2012

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration.

scientific article

Early and sustained activation of autophagy in degenerating axons after spinal cord injury

scientific journal article

Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease

scientific article published in February 2018

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

scientific article

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease

scientific article published on 22 April 2016

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo.

scientific article published on 26 April 2011

Imaging of rat optic nerve axons in vivo

scientific article

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

scientific article

JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.

scientific article

July 2017 ENCALS statement on edaravone

scientific article

MDS1 and EVI1 complex locus (MECOM): a novel candidate gene for hereditary hematological malignancies.

scientific article published on 2 November 2017

Mechanisms of acute axonal degeneration in the optic nerve in vivo

scientific article

MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation ⬇️

scientific article published on June 11, 2013

Plasmids containing NRSE/RE1 sites enhance neurite outgrowth of retinal ganglion cells via sequestration of REST independent of NRSE dsRNA expression.

scientific article published in September 2011

ROCK inhibition in models of neurodegeneration and its potential for clinical translation

scientific article published on 2 April 2018

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.

scientific article

ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.

scientific article

Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis-Symptomatic Treatment Potential after Disease Onset

scientific article published on 31 January 2017

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease

scientific article published in August 2014

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.

scientific article published on 6 December 2013

TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis

scientific article published on 02 December 2020

TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.

scientific article published on 6 March 2010

The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice

scientific article

The role of autophagy in axonal degeneration of the optic nerve.

scientific article published on 24 August 2015

Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro.

scientific article

Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells

scientific article

X‐ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons ⬇️

scientific article published on December 5, 2012

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