List of works - George Thomas

A matter of energy stress: p38β meets mTORC1

scientific article

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

scientific article (publication date: 9 September 2004)

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

scientific article

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

scientific article

Bending the path to TOR.

scientific article

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

scientific article

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

scientific article

Hypothalamic mTOR signaling regulates food intake

scientific article (publication date: 12 May 2006)

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

scholarly article

Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data

scientific article

Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.

scientific article published on 23 September 2013

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

scientific article

Metabolic control by S6 kinases depends on dietary lipids

scientific article (publication date: 2012)

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

scientific article

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

scientific article

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

scientific article published on 02 June 2020

Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.

scientific article published in April 2010

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together ⬇️

scientific article published on March 27, 2012

Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis

scientific article published on 2 April 2004

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

scientific article

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

scientific article

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

Research and innovation in the development of everolimus for oncology.

scientific article published on 17 February 2011

S6K1 plays a critical role in early adipocyte differentiation

scientific article

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

scientific article

The amino acid sensitive TOR pathway from yeast to mammals.

scientific article

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

scientific article published in March 2005

The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila

scientific article

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

scientific article

mTOR, cancer and transplantation.

scientific article published on 10 September 2008

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

scientific article

List of works by George Thomas

A matter of energy stress: p38β meets mTORC1

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

Bending the path to TOR.

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

Hypothalamic mTOR signaling regulates food intake

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data

Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

Metabolic control by S6 kinases depends on dietary lipids

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together ⬇️

Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Research and innovation in the development of everolimus for oncology.

S6K1 plays a critical role in early adipocyte differentiation

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

The amino acid sensitive TOR pathway from yeast to mammals.

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

mTOR, cancer and transplantation.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs