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List of works by Kohsuke Takeda

A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis

scientific article

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

scientific article published on 01 November 2012

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

scientific article published on June 2008

ASK family proteins in stress response and disease

scientific article published on September 2007

ASK1 Signalosome: a Signaling Complex Essential for Cellular Stress Responses

article

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

scientific article published on 12 February 2009

ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.

scientific article published on 28 July 2017

ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction

scientific article (publication date: 20 October 2000)

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

scientific article

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

scholarly article by K Tobiume published in March 2001

ASK1 promotes the contact hypersensitivity response through IL-17 production

scientific article published on 16 April 2014

ASK1 signalling regulates brown and beige adipocyte function.

scientific article published on 5 April 2016

ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds

scientific article

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

scientific article published in Nature Communications

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

scientific article

Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1

scientific article

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

scientific article (publication date: 31 March 2000)

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

scientific article

Apoptosis signal-regulating kinase 1 in stress and immune response

scientific article published on January 2008

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.

scientific article

Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.

scientific article

Apoptosis signaling kinases: from stress response to health outcomes

scientific article published on 20 April 2011

Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons

scientific article published in June 2003

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

scientific article

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein

scientific journal article

Characterization of two length cDNA for human MSX-2 from dental pulp-derived cells

scientific article

Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling

scientific article

Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy

scientific article published on 01 January 2019

Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library

scientific article

ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips

scientific article published on 08 August 2016

ERK signalling as a regulator of cell motility

scientific article published in September 2017

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

scientific article published in Journal of Biological Chemistry

Expression of bone morphogenetic protein genes in the human dental pulp cells.

scientific article published on September 1994

Expression of mRNA encoding tissue-nonspecific alkaline phosphatase in human dental tissues

scientific article published on 01 February 1999

Expression of prostaglandin E receptor subtypes in bone: expression of EP2 in bone development.

scientific article published on July 1995

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

scientific article

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

scientific article

Homeobox gene expression during bone formation induced by BMP

scientific article published on 01 June 1996

Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.

scientific article published on 16 December 2009

Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade

scientific article published in February 2006

Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

scientific article

Identification of novel ASK1 inhibitors using virtual screening

scientific article

Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7

scientific article (publication date: December 2001)

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation

scientific article published on 16 January 2004

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion

scientific article published on 15 February 2013

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

scientific article

Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation

scientific article published on 17 January 2017

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

scientific article

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.

scientific article

Molecular cloning and sequence of bovine Msx-1 homeobox-containing gene cDNA from a bovine odontoblast library.

scientific article published on January 1995

Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP.

scientific article published on October 1994

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

scientific journal article

Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

scientific article

Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

scientific article published on 9 September 2002

Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

scientific article (publication date: 25 October 2002)

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

scientific article

Physiological roles of stress-activated protein kinases in skin

Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster

scientific article

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

scientific article

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

scientific article

Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins

scientific article

Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.

scientific article published on 22 January 2008

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

scientific article published on 22 August 2012

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

scientific article

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

scientific article published on 26 September 2013

Stress signaling in cancer.

scientific article published on 23 July 2007

Stress-activated MAP kinase cascades in cellular senescence.

scientific article published on January 2009

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

scientific article published on 10 June 2017

TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells

scientific article

The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response

scientific article

The ASK1-MAP kinase cascades in mammalian stress response

scientific article

The ASK1-MAP kinase pathways in immune and stress responses

scientific article

The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases

scientific article

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

scientific article published on 29 January 2016

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses

scientific article published on 29 April 2014

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

scientific article

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

scientific article published on 20 January 2014

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

scientific article

The phosphorylation-dependent regulation of mitochondrial proteins in stress responses

scientific article

Therapeutic targets in the ASK1-dependent stress signaling pathways

scientific article

Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1

scientific article

Thioredoxin and protein kinases in redox signaling.

scientific article published on 26 September 2006

Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

scientific article published on 01 December 1999

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

scientific article

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

scientific article

WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.

scientific article

p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.

scientific article published in September 2011

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress

scientific article published on 18 July 2018

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