List of works - Urs Christen

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis

scientific article published on 01 June 2001

A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds.

scientific article published on 17 January 2018

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

scientific article published on November 2004

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes

scientific article

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

scientific article published in December 2003

An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?

scientific article published on January 2015

Animal models for autoimmune hepatitis.

scientific article published on 6 May 2006

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

scientific article

Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES.

scientific article published on 30 January 2017

Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing.

scientific article

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

scientific article published on 15 December 2017

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice

scientific article

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

scientific article published on 12 May 2008

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

scientific article published on 9 February 2003

CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation ⬇️

scientific article published on October 6, 2010

Cost of institute was small change to Roche

journal article; published in Nature on 2000-8

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

scientific article published on 01 June 2006

Cytochrome P450 2D6 as a model antigen

scientific article published on 7 May 2010

Cytokines and chemokines in virus-induced autoimmunity.

scientific article

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

scientific article published on March 2005

Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

scientific article published on October 2002

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

scientific article

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.

scientific article

Editorial: pathogen infection and autoimmunity

scientific article published on 01 July 2014

Enterovirus infection of human beta-cells activates dendritic cells and triggers innate antiviral responses: are enteroviruses convicted now?

scientific article published on May 2010

Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model.

scientific article published on 26 July 2011

GAD autoantibody affinity in schoolchildren from the general population

scientific article published on 18 June 2014

Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts

scientific journal article

IP-10 and type 1 diabetes: a question of time and location.

scientific article

Immune response to a recombinant human TNFR55-IgG1 fusion protein: auto-antibodies in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients have neither neutralizing nor agonist activities

scientific article published on 01 September 1999

Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?

scientific article

Infection as a cause of type 1 diabetes?

scientific article

Infections and autoimmunity--good or bad?

scientific article

Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study

scientific article

Initiation of autoimmunity.

scientific article

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes.

scientific article

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development

scientific article published on 01 September 2005

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

scientific article

Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.

scientific article published in April 2007

Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.

scientific article

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

scientific article

Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.

scientific article published on 25 April 2016

New animal models for autoimmune hepatitis.

scientific article published on 12 August 2009

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model

scientific article

Pathogen infection and autoimmune disease

scientific article published on 01 January 2019

Pathogen infection as a possible cause for autoimmune hepatitis.

scientific article

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.

scientific article published on 10 February 2017

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

scientific journal article

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

scientific article published on 10 October 2006

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

scientific article published on 26 April 2007

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice.

scientific article

The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis ⬇️

scientific article published on 24 November 2019

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

scientific article published in July 1992

The role of autoantibodies in autoimmune hepatitis type 2.

scientific article published on March 2013

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes

scientific article published on January 2015

Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model.

scientific article

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation

scientific article

Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity

scientific article published on 01 April 2020

Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.

scientific article

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

scientific article published on March 2004

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

scientific article published in November 2000

List of works by Urs Christen

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis

A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds.

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?

Animal models for autoimmune hepatitis.

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES.

Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is already ongoing.

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation ⬇️

Cost of institute was small change to Roche

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

Cytochrome P450 2D6 as a model antigen

Cytokines and chemokines in virus-induced autoimmunity.

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.

Editorial: pathogen infection and autoimmunity

Enterovirus infection of human beta-cells activates dendritic cells and triggers innate antiviral responses: are enteroviruses convicted now?

Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model.

GAD autoantibody affinity in schoolchildren from the general population

Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts

IP-10 and type 1 diabetes: a question of time and location.

Immune response to a recombinant human TNFR55-IgG1 fusion protein: auto-antibodies in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients have neither neutralizing nor agonist activities

Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?

Infection as a cause of type 1 diabetes?

Infections and autoimmunity--good or bad?

Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study

Initiation of autoimmunity.

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes.

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.

Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.

New animal models for autoimmune hepatitis.

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model

Pathogen infection and autoimmune disease

Pathogen infection as a possible cause for autoimmune hepatitis.

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice.

The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis ⬇️

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

The role of autoantibodies in autoimmune hepatitis type 2.

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes

Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model.

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation

Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity

Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.