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List of works by Oliver T Fackler

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.

scientific article published on 23 December 2015

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

scientific article

Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism

scientific article published on 10 July 2003

Adding new dimensions: towards an integrative understanding of HIV-1 spread.

scientific article published on August 2014

Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.

scientific article

Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins

scientific article

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

scientific article

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

scientific article

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1

scientific article

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

article

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles

scientific article published on 9 December 2015

Cell motility through plasma membrane blebbing

scientific article

Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivative

scientific article

Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives

scientific article published on September 2004

Contact-dependent inhibition of HIV-1 replication in <i>ex vivo</i> human tonsil cultures by polymorphonuclear neutrophils

scientific article published on 15 June 2021

Correction: The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

scientific article published on 01 December 2019

D186/D190 is an allele-dependent determinant of HIV-1 Nef function

scientific article published on 22 August 2016

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture

scientific article

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

scientific article published on 15 January 2009

Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation

scientific article published on 20 December 2011

Endocytic entry of HIV-1.

scientific article published on August 2000

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

scientific article published on 18 April 2017

Evidence for the association of Nef protein with HIV-2 virions

article

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

article

Experimental systems for studying Plasmodium/HIV coinfection

scientific article published on 24 March 2016

Expression of HIV-1 pathogenesis factor NEF in CD4 T cells impairs antigen-specific B-cell function

scientific article published on 04 November 2020

Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection

scientific article

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

scientific article published in 2022

FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation

scientific article

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement

scientific article

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

scientific article published on 26 February 2013

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

scientific article (publication date: 10 January 2017)

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

scientific article published on 5 August 2015

Functional characterization of HIV-1 Nef mutants in the context of viral infection

scientific article

Functional characterization of HIV-1 Nef proteins with heterologous membrane targeting signals

scientific article published on 19 September 2013

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

scientific article published on 21 November 2019

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

scientific article published on 19 October 2016

HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface

article

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins

scientific article published on October 2014

HIV-1 Nef compensates for disorganization of the Immunological Synapse by inducing TGN-associated Lck signaling.

scientific article published on 3 October 2011

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

scientific article published on 28 November 2011

HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases

scientific article published on 3 May 2013

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

scientific article

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

scientific article

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

scientific article

HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation

scientific article published on 16 July 2012

HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor

scientific article published on April 2009

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

scientific article

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites

scientific article published on 11 May 2016

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

scientific article published on 22 March 2013

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction ⬇️

scientific article published on 24 May 2011

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin

scientific article published on 4 January 2012

HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor

scientific article published on March 2009

HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation of the intrinsic immunity factor

article

HIV-1 at the immunological and T-lymphocytic virological synapse

scientific article published on October 2008

HIV-1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV-infected patients

article

HIV-1 reprograms the migration of macrophages

scientific article published on 19 December 2014

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

scientific article published on 3 March 2016

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef

scientific article

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication ⬇️

scientific article published on March 28, 2011

Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec

scientific article (publication date: 16 February 2009)

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

scientific article published on April 2004

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

scientific article

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

scientific article

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

scientific article

Hydrophilic trans-Cyclooctenylated Noncanonical Amino Acids for Fast Intracellular Protein Labeling

scientific article published on 25 May 2016

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

scientific article published on 27 April 2012

Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

scientific article

Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

scientific article published on 2 September 2009

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

scientific article published on 3 February 2011

Integrative analysis of pathogen replication and spread: zooming into increasing complexity

scientific article published in July 2016

Interactions of human retroviruses with the host cell cytoskeleton

scientific article published on 3 July 2006

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.

scientific article published on 27 March 2018

Involvement of Clathrin-Mediated Endocytosis in Human Immunodeficiency Virus Type 1 Entry

scientific article

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling

scientific article

Lessons from HIV: movement of macromolecules inside the cell.

scientific article

Live and let die: Nef functions beyond HIV replication

scientific article

Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites.

scientific article published on 24 January 2017

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

scientific article published on 20 March 2015

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

scientific article published on 19 December 2005

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

scientific article published on April 2007

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

scientific article

Molecular effects in tritiumβdecay. II. Rotation-vibration excitation, dissociation, and rotational predissociation in the decay of theT2and TH molecules

article

Multifunctional Roles of the N-Terminal Region of HIV-1SF2Nef Are Mediated by Three Independent Protein Interaction Sites

scientific article published on 12 December 2019

MxB/Mx2: the latest piece in HIV's interferon puzzle

scientific article

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

scientific article published on 03 January 2020

Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.

scientific article published on May 2004

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

article

Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV.

scientific article published on 3 October 2011

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

scientific article

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

scientific article

Observation of Muon Neutrino Disappearance with the MINOS Detectors in the NuMI Neutrino Beam

scientific article

Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities

scientific article

Patient-derived HIV-1 Nef alleles reveal uncoupling of CD4 downregulation and SERINC5 antagonism functions of the viral pathogenesis factor

scientific article published on 08 June 2020

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

scientific article

Potential impact of the antirheumatic agent auranofin on proviral HIV-1 DNA in individuals under intensified antiretroviral therapy: Results from a randomised clinical trial

scientific article published on 05 August 2019

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4<sup>+</sup> T cells allows complex functional analyses

scientific article published on 23 December 2021

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

scientific article

Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement

scientific article published on 17 June 2015

Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa

scientific article

Restrictions to HIV-1 replication in resting CD4 T lymphocytes

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes ⬇️

scientific article published on 04 June 2013

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef

scientific article

Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes

scientific article

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

scientific article

SAMHD1's protein expression profile in humans

scientific article

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

scientific article published on 14 January 2020

SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility

scientific article published in November 2007

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

article

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.

scientific article published on 9 December 2015

Similar proviral load but increased HIV-1 p24 in the intestinal mucosa compared to the peripheral blood in HIV-infected patients.

scientific article published in November 1998

Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.

scientific article

Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

scientific article published on 17 August 2006

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

scientific article published on 19 December 2015

Structure--function relationships in HIV-1 Nef.

scientific article

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

scientific article

Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins

scientific article

Tailored environments to study motile cells and pathogens.

scientific article published on 7 January 2018

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

scientific article published on 28 September 2016

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

scientific article

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication <i>In Vitro</i> and Decreases Viral Titers and Disease Progression in Syrian Hamsters

scientific article published on 01 March 2022

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

scientific article

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

scientific article

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling

scientific article published on 14 June 2006

The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner

scientific article

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

scientific article published on 19 December 2018

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

scientific article published on 28 June 2017

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation

scientific article

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement

scientific article

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

scientific article published on 22 February 2017

cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients

scientific article

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

scientific article

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

scientific article published on 10 February 2011

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