List of works - Hans-Ulrich Klein

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

article

A new workflow for whole-genome sequencing of single human cells

scientific article published on 18 August 2014

Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

scientific article published on 02 December 2021

BRCC3 mutations in myeloid neoplasms

scientific article published on 22 May 2015

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks

scientific article published on 07 April 2020

CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.

scientific article

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review

scientific article

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

scientific article published on 29 April 2013

Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data

scientific article

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

scientific article

Detection of significantly differentially methylated regions in targeted bisulfite sequencing data

scientific article

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

scientific article published on 04 September 2013

Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer.

scientific article

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

scientific article published on 17 December 2018

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

scientific article published on 29 December 2011

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

scientific article published on 29 March 2013

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

scientific article published on 22 December 2010

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

scientific journal article

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

scientific article published on 11 March 2012

Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements

scientific article

Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

scientific article

Leukemia gene atlas--a public platform for integrative exploration of genome-wide molecular data

scientific article

Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling ⬇️

scientific article published on January 11, 2013

Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)

scientific article published on 04 March 2010

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

article

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

scientific article

Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

scientific article

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data ⬇️

scientific article published on February 23, 2011

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells

scientific article published on 24 November 2015

Robustness of Amplicon Deep Sequencing Underlines Its Utility in Clinical Applications

scholarly article by Vera Grossmann et al published July 2013 in The Journal of Molecular Diagnostics

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology

scientific article

The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories.

scientific article published on 17 June 2011

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

scientific article

List of works by Hans-Ulrich Klein

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

A new workflow for whole-genome sequencing of single human cells

Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

BRCC3 mutations in myeloid neoplasms

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks

CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

Detection of significantly differentially methylated regions in targeted bisulfite sequencing data

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer.

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements

Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

Leukemia gene atlas--a public platform for integrative exploration of genome-wide molecular data

Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling ⬇️

Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data ⬇️

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells

Robustness of Amplicon Deep Sequencing Underlines Its Utility in Clinical Applications

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology

The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories.

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype