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List of works by Wouter de Laat

3C technology: analyzing the spatial organization of genomic loci in vivo.

scientific article

3C-based technologies to study the shape of the genome

scientific article published on November 2012

3D chromatin conformation correlates with replication timing and is conserved in resting cells

scientific article

4C technology: protocols and data analysis.

scientific article

4C-seq from beginning to end: A detailed protocol for sample preparation and data analysis

scientific article published on 26 July 2019

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

scientific article

A Long-Distance Chromatin Affair

scientific article published on 01 August 2015

A common genetic variant within SCN10A modulates cardiac SCN5A expression

scientific article published on 18 March 2014

A decade of 3C technologies: insights into nuclear organization

scientific article published on January 2012

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

scientific article published on 24 June 2014

A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response.

scientific article published on 18 January 2016

A regulatory archipelago controls Hox genes transcription in digits

scientific article

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

scientific article

Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.

scientific article published on 7 June 2013

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

scientific article published on 30 October 2019

An evaluation of 3C-based methods to capture DNA interactions

scientific article

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation.

scientific article published in January 2011

Architectural hallmarks of the pluripotent genome.

scientific article published on 07 May 2015

Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice

scientific article

Beta-globin regulation and long-range interactions

scientific article published on January 2008

CTCF Binding Polarity Determines Chromatin Looping.

scientific article published on 27 October 2015

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

scientific journal article

CTCF: the protein, the binding partners, the binding sites and their chromatin loops ⬇️

scientific article published on May 6, 2013

Can We Just Say: Transcription Second?

scientific article published in April 2017

Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments.

scientific article

Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming

scientific article

Characterization and dynamics of pericentromere-associated domains in mice

scientific article

Chromatin loops, gene positioning, and gene expression

scientific article

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

scientific article

DNA structural elements required for ERCC1-XPF endonuclease activity.

scientific article published on April 1998

DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair ⬇️

scientific article published on August 15, 1998

Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: from fixation to computation.

scientific article

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

scientific article (publication date: 10 May 2016)

Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

scientific article

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

scientific article

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

scientific article

Enhancer hubs and loop collisions identified from single-allele topologies

scientific article published on 09 July 2018

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.

scientific article

Enhancers reside in a unique epigenetic environment during early zebrafish development

scientific article published on 5 July 2016

Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation

scientific article published on 06 November 2020

Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

scientific article published on 18 June 2020

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain.

scientific article published on 25 January 2016

Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

scientific article published on 5 February 2016

Erratum: Corrigendum: Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

scholarly article published in Nature

FISH-eyed and genome-wide views on the spatial organisation of gene expression

scientific article published on 05 August 2008

For genomes to stay in shape, insulators must be up to PAR.

scientific article published in September 2013

Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart

scientific article published on 27 October 2020

Genome organization influences partner selection for chromosomal rearrangements

scientific article published on 07 December 2010

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

scientific article published on January 2013

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA.

scientific article

Getting the genome in shape: the formation of loops, domains and compartments

scientific article (publication date: 2015)

High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila

scientific article published on October 2015

High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology

scientific article published on 11 October 2009

Identical cells with different 3D genomes; cause and consequences?

scientific article published on 14 February 2013

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia

scientific article published in April 2011

Inter-chromosomal gene regulation in the mammalian cell nucleus

scientific article published on 20 September 2007

Interactions among Polycomb domains are guided by chromosome architecture

scientific article

Joining the loops: beta-globin gene regulation

scientific article published on December 2008

Large-scale identification of coregulated enhancer networks in the adult human brain

scientific article published on 16 October 2014

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells

scientific article

Long-range DNA contacts: romance in the nucleus?

scientific article published on 27 April 2007

Looping and interaction between hypersensitive sites in the active beta-globin locus

scientific article (publication date: December 2002)

Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription

scientific article

Mapping of interaction domains between human repair proteins ERCC1 and XPF

scientific article

Molecular mechanism of nucleotide excision repair.

scientific article

Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies

scientific article published on 13 January 2020

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

scientific article

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

scientific article

Polarized regulatory landscape and Wnt responsiveness underlie Hox activation in embryos

scientific article published on 15 September 2016

Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2

scientific article published on 21 November 2015

Quantitative analysis of chromosome conformation capture assays (3C-qPCR).

scientific article

Regulation of disease-associated gene expression in the 3D genome

scientific article published on 9 November 2016

Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes

scientific article published on 04 March 2007

Robust 4C-seq data analysis to screen for regulatory DNA interactions.

scientific article

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

scientific article published on 07 June 2021

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

scientific article published on 18 August 2017

Small chromosomal regions position themselves autonomously according to their chromatin class.

scientific article published on 24 March 2017

Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics ⬇️

scientific article published on July 1, 1995

Spatial organization of gene expression: the active chromatin hub.

scientific article

Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C).

scientific article

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping.

scientific article published on 17 August 2014

The active spatial organization of the beta-globin locus requires the transcription factor EKLF

scientific journal article

The beta-globin nuclear compartment in development and erythroid differentiation

scientific article published on 21 September 2003

The complex transcription regulatory landscape of our genome: control in three dimensions

scientific article

The dynamic architecture of Hox gene clusters

scientific article

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

scientific article

The pluripotent genome in three dimensions is shaped around pluripotency factors

scientific article published on 24 July 2013

The second decade of 3C technologies: detailed insights into nuclear organization

scientific article

Three-dimensional organization of gene expression in erythroid cells

scientific article published on January 2008

Tissue- and expression level-specific chromatin looping at maize b1 epialleles

scientific article published on 31 March 2009

Topology of mammalian developmental enhancers and their regulatory landscapes

scientific article

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region

scientific article

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination.

scientific article published on 22 October 2015

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

scientific article published on 27 December 2017

Variegated gene expression caused by cell-specific long-range DNA interactions

scientific article published on 26 June 2011

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

scientific article

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

scientific article published on 14 February 2019

eRNAs are required for p53-dependent enhancer activity and gene transcription

scientific article

peakC: a flexible, non-parametric peak calling package for 4C and Capture-C data

scientific article published on 01 September 2018

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