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List of works by Kiichi Hirota

6-formylpterin, a xanthine oxidase inhibitor, intracellularly generates reactive oxygen species involved in apoptosis and cell proliferation.

scientific article

A proposal for a new temperature-corrected formula for the oxygen content of blood

scientific article published on 12 August 2020

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.

scientific article

Accidental administration of the remifentanil formulation Ultiva™ into the epidural space and the complete time course of its consequences: a case report

scientific article published on 08 August 2016

Alpha-phenyl-N-tert-butyl nitrone has scavenging activity against singlet oxygen ((1)O(2)) and attenuates (1)O(2)-induced neuronal cell death.

scientific article

An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF-kappaB by lysophosphatidic acid.

scientific article

Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine

scientific article published on 13 February 2020

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

scientific article published on 17 April 2012

Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma

scientific article published on 15 April 2019

Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium

scientific article published on 03 January 2021

Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner.

scientific article published on 29 September 2016

Comparison of continuous intraarterial blood gas analysis and transcutaneous monitoring to measure oxygen partial pressure during one-lung ventilation

scientific article published on 30 January 2007

Complete resolution of myoclonus-like involuntary movements under subarachnoid block after midazolam administration in a patient undergoing cesarean section: a case report.

scientific article

Critical Care Demand and Intensive Care Supply for Patients in Japan with COVID-19 at the Time of the State of Emergency Declaration in April 2020: A Descriptive Analysis

scientific article published on 12 October 2020

Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system

scientific article (publication date: 3 May 1999)

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging

scientific article

Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.

scientific article published on 28 November 2013

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

scientific article

Ectopic ACTH syndrome revealed as severe hypokalemia and persistent hypertension during the perioperative period: a case report ⬇️

scientific article published on November 4, 2010

Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages.

scientific article

Effects of combined intravenous nicardipine and diltiazem administration on the circulatory response to laryngoscopy and tracheal intubation

scientific article published in June 1994

Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats ⬇️

scientific article published on July 29, 2011

Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock.

scientific article

Estimation of the number of general anesthesia cases based on a series of nationwide surveys on Twitter during COVID-19 in Japan: A statistical analysis

scientific article published on 12 May 2020

Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia.

scientific article

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity ⬇️

scientific article published on October 15, 2001

Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner

scientific article published on 17 June 2011

Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution

scientific article published on 26 January 2021

Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase.

scientific article published on 23 October 2006

General anesthetics inhibit LPS-induced IL-1β expression in glial cells

scientific article

General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain

scientific article

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death.

scientific article

Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner ⬇️

scientific article published on October 17, 2011

Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

scientific article published on May 2007

Hypoxia reduces constitutive and TNF-alpha-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells.

scientific article published in October 2005

Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells.

scientific article

Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression.

scientific article published in January 2002

Hypoxia-inducible factors are already "active" in the Von Hippel-Lindau-deficient renal cell carcinoma-4 cells.

scientific article published in June 2014

Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression

scientific article (publication date: 30 July 1999)

Impact of hydroxyethyl starch 70/0.5 on acute kidney injury after gastroenterological surgery

scientific article published on 25 July 2016

Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling

scientific article published on 26 July 2004

Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation.

scientific article published on November 2007

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

scientific article published on 30 July 2002

Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation

scientific article

Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells.

scientific article published on 18 June 2012

Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages

scientific article published on 13 January 2020

Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner

scientific article

Macrophage migration inhibitory factor diminishes muscle glucose transport induced by insulin and AICAR in a muscle type-dependent manner.

scientific article published on 25 January 2014

Meta-Analysis of Hypoxic Transcriptomes from Public Databases

scientific article published on 09 January 2020

Mitigation of inflammation using the intravenous anesthetic dexmedetomidine in the mouse air pouch model

scientific article published on 30 May 2017

Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty.

scientific article published on 14 May 2010

Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2.

scientific article

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling ⬇️

scientific article published on November 4, 2003

Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1, and CREB activation in HEK293 cells.

scientific article published on July 2000

Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines.

scientific article published on January 2005

Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.

scientific article published on February 2013

Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent manner

scientific article published on 18 December 2019

Pituitary apoplexy during general anesthesia in beach chair position for shoulder joint arthroplasty

scientific article published on 26 March 2010

Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

scientific article published on 15 February 2018

Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION™ nanopore sequencer

article

Real-time diagnostic analysis of MinION™-based metagenomic sequencing in clinical microbiology evaluation: a case report

scientific article published on 19 March 2019

Redox-sensitive transactivation of epidermal growth factor receptor by tumor necrosis factor confers the NF-kappa B activation.

scientific article published on 3 May 2001

Structure of the mouse thioredoxin-encoding gene and its processed pseudogene.

scientific article published in January 1995

Successful airway management with use of a laryngeal mask airway in a patient with CHARGE syndrome.

scientific article published on 18 November 2009

Successful perioperative airway management in a patient with angiomatous macroglossia for laser ablation under general anesthesia.

scientific article published on 26 April 2013

Successful perioperative management of a patient with primary systemic carnitine deficiency: a case report

scientific article published on 21 September 2012

Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity.

scientific article

Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells

scientific article published in August 2005

Takotsubo cardiomyopathy during ambulatory anesthesia for bladder hydrodistension therapy -A case report-

scientific article

Targeting cholesterol with β-cyclodextrin sensitizes cancer cells for apoptosis

scientific article published on 19 November 2015

The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

scientific article

The effects of local anesthetics on cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1.

scientific article published on January 2005

The impact of remifentanil on incidence and severity of postoperative nausea and vomiting in a university hospital-based ambulatory surgery center: a retrospective observation study.

scientific article published on 27 August 2013

The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner

scientific article published on 26 March 2014

The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation

scientific article published on January 2004

Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha

scientific article published on 01 May 1999

Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy

scientific article

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

scientific article

VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway.

scientific article published on 26 July 2016

Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1.

scientific article published on 10 December 2015

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