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List of works by Natasha J. Caplen

A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

scientific article

A new approach to the inhibition of gene expression

scientific article published on 01 February 2002

Adeno-retroviral chimeric viruses as in vivo transducing agents.

scientific article published in March 1999

Adenovirus Vectors as Transcomplementing Templates for the Production of Replication Defective Retroviral Vectors ⬇️

scientific article published on May 29, 1998

Allele-specific silencing of the dominant disease allele in sialuria by RNA interference.

scientific article published on 24 July 2008

Applications of RNA interference in mammalian systems.

scientific article published on January 2007

Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells

scientific article

Cancer biology functional genomics: From small RNAs to big dreams

scientific article published on 12 October 2020

Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.

scientific article published on 19 July 2012

EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

scientific article published on 19 June 2018

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma

scientific article published on 13 January 2016

Fusion transcripts: Unexploited vulnerabilities in cancer?

scientific article published on 13 August 2019

Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference.

scientific article published in August 2004

Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer ⬇️

scientific article published on January 14, 2013

Genomic instability and mouse microRNAs.

scientific article

HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

scientific article published on 11 September 2019

Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines

scientific article published on 03 August 2014

Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome

scientific article

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

scientific article

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

scientific article

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

scientific article

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

scientific article

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

article

Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity

scientific article

Mismatched siRNAs downregulate mRNAs as a function of target site location.

scientific article published on 5 June 2006

Multiplexing siRNAs to compress RNAi-based screen size in human cells.

scientific article published on 28 March 2007

Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

article

Pvt1-encoded microRNAs in oncogenesis

scientific article

RNAi Screening Identifies TAK1 as a Potential Target for the Enhanced Efficacy of Topoisomerase Inhibitors ⬇️

scientific article published on October 1, 2011

RNAi microarray analysis in cultured mammalian cells

scientific article

RNAi quashes polyQ.

scientific article

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

scientific article

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

scholarly article

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.

scientific article published on April 2008

SpliceCenter: a suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies

scientific article

Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.

scientific article published on 4 January 2012

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins

scientific article published on 26 February 2015

The 8q24 gene desert: an oasis of non-coding transcriptional activity.

scientific article published on 30 April 2012

The identification of microRNAs in a genomically unstable region of human chromosome 8q24.

scientific article

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

scientific article (publication date: March 2006)

p53-Dependent induction of PVT1 and miR-1204.

scientific article published on 22 November 2011

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