List of works - Hiroyasu Nakano

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

scientific article published on March 31, 1998

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

scientific article

NF-kappaB RelA phosphorylation regulates RelA acetylation

scientific journal article

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

scientific article

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

scientific article

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

scientific article published on 17 August 2005

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

scientific article (publication date: 28 September 2001)

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

scientific article

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

scientific article

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

scientific article

CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

scientific article

Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.

scientific article

Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

scientific article

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

scientific article

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

scientific article published on 10 January 2007

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

scientific article published in Journal of Biological Chemistry

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

scientific article

Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells

scientific article (publication date: 6 December 2002)

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

scientific article

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

scientific article

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

scientific article published on September 30, 2011

Crucial role for autophagy in degranulation of mast cells

scientific article published on 18 February 2011

Characterization of murine CD70 by molecular cloning and mAb

scientific article published on April 1, 1998

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

scientific article published in January 1998

TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.

scientific article

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

scientific article

cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2

scientific article published on March 6, 1998

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

scientific article

Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

scientific article

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

scientific article published on 18 December 2012

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.

scientific article published on 26 October 2012

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

scientific article published on 4 September 2013

Interleukin-11 links oxidative stress and compensatory proliferation.

scientific article published on 17 January 2012

Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells

scientific article published on 16 August 2006

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

scientific article

Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb

scientific article published on 01 September 1999

Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells

scientific article

Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death

scientific article published on July 2008

The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

scientific article

CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells

scientific article

FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

scientific article published on 7 March 2006

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis

scientific article

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease

scientific article

Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

scientific article published on 10 October 2012

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.

scientific article published on July 2005

TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation

scientific article published on 22 July 2010

Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas

scientific article published on August 1, 1995

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

scientific article

List of works by Hiroyasu Nakano

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

NF-kappaB RelA phosphorylation regulates RelA acetylation

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.

Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

Crucial role for autophagy in degranulation of mast cells

Characterization of murine CD70 by molecular cloning and mAb

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

Interleukin-11 links oxidative stress and compensatory proliferation.

Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb

Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells

Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death

The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells

FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease

Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.

TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation

Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.