List of works - Hiroyasu Nakano

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published in Nature Communications

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

scientific article

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

scientific article published on 19 June 2020

A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers

scientific article published on 18 December 2018

A revival of old players.

scientific article

Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice

scientific article published on 01 May 2012

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

scientific article published on 25 April 2019

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

scientific article

An unexpected role for autophagy in degranulation of mast cells.

scientific article published in June 2011

Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.

scientific article published on 26 March 2018

CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells

scientific article

CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

scientific article

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

scientific article published on 10 January 2007

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis.

scientific article published on 10 July 2015

Characterization of murine CD70 by molecular cloning and mAb ⬇️

scientific article published on April 1, 1998

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

scientific article

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

scientific article (publication date: 28 September 2001)

Crucial role for autophagy in degranulation of mast cells

scientific article published on 18 February 2011

Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum

scientific article published on 22 October 2016

Development of novel methods that monitor necroptosis and the release of DAMPs at the single cell resolution

scientific article published on 22 January 2019

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1 ⬇️

scientific article published on March 31, 1998

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

scientific article published on 4 September 2013

Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells

scientific journal article

Expansion of circulating gamma delta T cells in active sarcoidosis closely correlates with defects in cellular immunity.

scientific article published on March 1995

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

scientific article

FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

scientific article published on 7 March 2006

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

scientific article

Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

scientific article

Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice

scientific article published on 26 September 2018

Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.

scientific article published in July 2004

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

scientific article

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

scientific article published on 18 June 2019

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

scientific article

Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

scientific article published on 10 October 2012

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

scientific article published on 6 May 2006

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

scientific article published on 09 April 2020

Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells

scientific article

Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas ⬇️

scientific article published on August 1, 1995

Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TNF-Related Apoptosis-Inducing Ligand-Resistant Tumor Cells

scientific article published on 10 March 2020

Interleukin-11 links oxidative stress and compensatory proliferation.

scientific article published on 17 January 2012

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

scientific article published on 16 April 2021

Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb

scientific article published on 01 September 1999

Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells

scientific article published on 16 August 2006

Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death

scientific article published on July 2008

Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.

scientific article

NF-kappaB RelA phosphorylation regulates RelA acetylation

scientific journal article

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

scientific article

NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis

scientific article

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

scientific article published on 14 May 2019

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome

scientific article

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.

scientific article published on July 2005

Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells

scientific article (publication date: 6 December 2002)

Protection against Fas-mediated and tumor necrosis factor receptor 1-mediated liver injury by blockade of FADD without loss of nuclear factor-kappaB activation

scientific article

Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

scientific article

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.

scientific article published on 26 October 2012

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

scientific article

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

scientific article

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

scientific article published in Journal of Biological Chemistry

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

scientific article

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

scientific article

Short form FLICE-inhibitory protein promotes TNFα-induced necroptosis in fibroblasts derived from CFLARs transgenic mice

scientific article published on 06 October 2016

TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.

scientific article

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis

scientific article

TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation

scientific article published on 22 July 2010

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

scientific article

The AP-1 transcription factor JunB is required for Th17 cell differentiation

scientific article published on 12 December 2017

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

scientific article

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

scientific article

The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

scientific article

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

scientific article published on 17 August 2005

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease

scientific article

Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

scientific article

Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.

scientific article

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

scientific article published in January 1998

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

scientific article

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

scientific article

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

scientific article published on 18 December 2012

cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2 ⬇️

scientific article published on March 6, 1998

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition ⬇️

scientific article published on September 30, 2011

List of works by Hiroyasu Nakano

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers

A revival of old players.

Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

An unexpected role for autophagy in degranulation of mast cells.

Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.

CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells

CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis.

Characterization of murine CD70 by molecular cloning and mAb ⬇️

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

Crucial role for autophagy in degranulation of mast cells

Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum

Development of novel methods that monitor necroptosis and the release of DAMPs at the single cell resolution

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1 ⬇️

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells

Expansion of circulating gamma delta T cells in active sarcoidosis closely correlates with defects in cellular immunity.

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice

Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells

Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas ⬇️

Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TNF-Related Apoptosis-Inducing Ligand-Resistant Tumor Cells

Interleukin-11 links oxidative stress and compensatory proliferation.

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb

Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-kappaB in endothelial cells

Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death

Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.

NF-kappaB RelA phosphorylation regulates RelA acetylation

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome

Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.

Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells

Protection against Fas-mediated and tumor necrosis factor receptor 1-mediated liver injury by blockade of FADD without loss of nuclear factor-kappaB activation

Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells.

Short form FLICE-inhibitory protein promotes TNFα-induced necroptosis in fibroblasts derived from CFLARs transgenic mice

TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis

TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation

TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.

The AP-1 transcription factor JunB is required for Th17 cell differentiation

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation

The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease

Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis