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List of works by Pablo Pelegrín

2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential

scientific article published on 08 August 2012

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages

scientific article published on 17 April 2019

A fish cell surface receptor defined by a mAb mediates leukocyte aggregation and deactivation

scientific article published on 01 September 2001

A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity

scientific article

A role for acidophilic granulocytes in the testis of the gilthead seabream (Sparus aurata L., Teleostei).

scientific article published in November 2003

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

scientific article

ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-κB activation.

scientific article published on 19 May 2014

Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum

scientific article published on 25 March 2004

Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP

scientific article published on 10 October 2006

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

scientific article

Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

scientific article published on 01 December 2020

Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism

scientific article

C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation

scientific article published on 8 April 2010

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis

scientific article published on 02 November 2020

Cell volume regulation modulates NLRP3 inflammasome activation

scientific article

Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic response

scientific article published on 15 March 2002

Current status of inflammasome blockers as anti-inflammatory drugs ⬇️

scientific article published on May 22, 2012

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

scientific article published on 14 April 2017

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates

scientific article published on 18 June 2009

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

scientific article published on 08 April 2019

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

scientific article

Editorial overview: Purinergic P2X receptors in innate immunity and inflammation

scientific article published on 12 June 2019

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.

scientific article

Identification of Thr283 as a key determinant of P2X7 receptor function

scientific article published on 29 August 2006

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

scientific article

Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines.

scientific article published on October 2001

Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids

scientific article published on 03 August 2007

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury.

scientific article published on 8 December 2016

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death.

scientific article published on 25 May 2016

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

scientific article published on 23 February 2016

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

scientific article

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

scientific article published on 20 December 2016

MCC950 closes the active conformation of NLRP3 to an inactive state

scientific article published on 13 May 2019

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

scientific article published on 03 March 2016

Many ways to dilate the P2X7 receptor pore ⬇️

scientific article published on July 1, 2011

Measuring IL-1β Processing by Bioluminescence Sensors I: Using a Bioluminescence Resonance Energy Transfer Biosensor

scientific article

Measuring NLR Oligomerization III: Detection of NLRP3 Complex by Bioluminescence Resonance Energy Transfer

scientific article

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

scientific article published on 27 June 2016

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates ⬇️

scientific article published on July 8, 2012

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish

scientific article published on 3 July 2007

Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature

scientific article published on 17 April 2002

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

scientific article published in Nature Communications

Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

scientific article published on July 2016

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules ⬇️

scientific article published on December 28, 2010

P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

scientific article published on 17 January 2011

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

scientific article published on 16 July 2010

P2X7 Receptor-Dependent Intestinal Afferent Hypersensitivity in a Mouse Model of Postinfectious Irritable Bowel Syndrome

scientific article published on 22 June 2011

P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells

scientific article

P2X7 receptor antagonism in the treatment of cancers ⬇️

scientific article published on May 27, 2011

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

scientific journal article

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

scientific article

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

scientific article

P2X7 receptors mediate resistance to toxin-induced cell lysis

scientific article published on 31 January 2014

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway

scientific article published on 22 November 2006

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

scientific article

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

scientific article published on February 2009

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells

scientific article published on 20 November 2008

Phylogeny of cytokines: molecular cloning and expression analysis of sea bass Dicentrarchus labrax interleukin-1β

article

Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream

scientific article published on March 2004

Purinergic receptors and the inflammatory response mediated by lipids

article

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

scientific article published on 17 September 2015

Reprogramming macrophages by plasmin

scientific article published in May 2017

Response to Boyle et al

scientific article

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

scientific article published on 05 December 2016

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4

scientific article published on 06 May 2019

Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production ⬇️

scientific article published on 30 June 2020

Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1.

scientific article published on October 2008

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.

scientific article published on 27 January 2017

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

scientific article (publication date: August 2014)

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release

scientific article published on 12 February 2009

The gasdermins, a protein family executing cell death and inflammation

scientific article published on 05 November 2019

The inflammasome pathway in stable COPD and acute exacerbations

scientific article

The participation of plasma membrane hemichannels to purinergic signaling

scientific article

The tumor necrosis factor alpha of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner.

scientific article published in June 2004

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives ⬇️

scientific article

WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance

scientific article published on 02 July 2019

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