List of works - Isabel Roditi

A Glycosylation Mutant of Trypanosoma brucei Links Social Motility Defects In Vitro to Impaired Colonization of Tsetse Flies In Vivo

scientific article published on 10 April 2015

A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei.

scientific article

A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.

scientific article published in January 2007

A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.

scientific article

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes

scientific article published on 2 March 2016

A transient CRISPR/Cas9 expression system for genome editing in Trypanosoma brucei

scientific article published on 03 June 2020

Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery

scientific article (publication date: 2011)

An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition

scientific article published on 25 January 2021

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei

scientific article

An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei.

scientific article published in September 1999

Antagonistic effects of IL-4 and interferon-gamma (IFN-gamma) on inducible nitric oxide synthase expression in bovine macrophages exposed to gram-positive bacteria.

scientific article published in September 1997

Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei.

scientific article published on 16 June 2009

Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei.

scientific article

Characterisation and cellular localisation of a GPEET procyclin precursor in Trypanosoma brucei insect forms.

scientific article

Cleavage of trypanosome surface glycoproteins by alkaline trypsin-like enzyme(s) in the midgut of Glossina morsitans

scientific article published in October 2003

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

scientific article published on 05 December 2019

Contributions of the procyclin 3' untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei.

scientific article published in October 1997

Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: a dual role for polypyrimidine tracts in trypanosomes?

scientific article

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

scientific article

Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes

scientific article published on 01 February 2022

Cycloheximide-mediated accumulation of transcripts from a procyclin expression site depends on the intergenic region.

scientific article

DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide

scientific article

Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host

scientific article published on 20 September 2021

Editing the Trypanosoma cruzi genome with zinc finger nucleases

scientific article published on 17 January 2017

Elements in the 3' untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation

scientific article published on August 1997

Environmental sensing by African trypanosomes.

scientific article published on 27 April 2016

Expression of GARP, a major surface glycoprotein of Trypanosoma congolense, on the surface of Trypanosoma brucei: characterization and use as a selectable marker.

scientific article published on March 1995

Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes.

scientific article published on 16 June 2004

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei

scientific article

Flagellar cAMP signaling controls trypanosome progression through host tissues

scientific article published on 18 February 2019

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

scientific article

Functional characterization of the trypanosome translational repressor SCD6

scientific article published on 01 January 2014

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

scientific article

Glutamic acid/alanine-rich protein from Trypanosoma congolense is the functional equivalent of 'EP' procyclin from Trypanosoma brucei

scientific article published on 01 January 1999

Glycosylphosphatidylinositol-anchored surface molecules of Trypanosoma congolense insect forms are developmentally regulated in the tsetse fly.

scientific article published in January 2002

Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel

scientific article

Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.

scientific article published on 2 March 2007

Identification and characterization of an acidic major surface glycoprotein from procyclic stage Trypanosoma congolense.

scientific article published in October 1993

Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum

scientific article

Identification of bracovirus particle proteins and analysis of their transcript levels at the stage of virion formation

scientific article

Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei.

scientific article published on 27 September 2013

Interactions between trypanosomes and tsetse flies.

scientific article published on 30 July 2008

Lymphocytes infected with Theileria parva require both cell-cell contact and growth factor to proliferate.

scientific article published on January 1991

MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans.

scientific article published on 8 September 2012

Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse

scientific article

Molecular characterization of glycosomal NAD(+)-dependent glycerol 3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense.

scientific article published in February 1996

Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei.

scientific article published in September 2001

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

scientific article published on 14 April 2015

Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.

scientific article published on 26 April 2013

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection

scientific article

Phosphorylation of GPEET procyclin is not necessary for survival of Trypanosoma brucei procyclic forms in culture and in the tsetse fly midgut.

scientific article published in February 2003

Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane

scientific article published on 01 June 1999

Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surface

scientific article

Production and characterisation of monoclonal antibodies specific for bovine interleukin-4

article

RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages.

scientific article published on 2 April 2018

Remote Sensing of Potential Biosignatures from Rocky, Liquid, or Icy (Exo)Planetary Surfaces.

scientific article published on 10 March 2017

Rodent-free cyclical transmission of Trypanosoma brucei brucei

article

Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei

scientific article published on 02 September 2008

Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.

scientific article published on 18 April 2007

Sequence analysis of fowl plague virus mutant ts47 reveals a nonsense mutation in the NS1 gene.

scientific article published on April 1983

Social motility of African trypanosomes is a property of a distinct life-cycle stage that occurs early in tsetse fly transmission.

scientific article

Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.

scientific article

Stable expression of biologically active recombinant bovine interleukin-4 in Trypanosoma brucei.

scientific article published in November 2001

The Social Life of African Trypanosomes

scientific article published on October 2015

The VSG-procyclin switch

scientific article published on 01 February 1996

The languages of parasite communication.

scientific article published on 17 May 2016

The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse

scientific article

The regulation of procyclin expression in Trypanosoma bruceli: making or breaking the rules?

scientific article published in November 1994

The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei.

scientific article published on May 1994

The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei.

scientific article published on December 1987

Trypanosoma (Nannomonas) simiae and T. (N.) godfreyi have genes encoding glutamic acid and alanine-rich proteins.

scientific article published in March 2004

Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.

scientific article published on 17 March 2015

Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters ⬇️

scientific article published on October 1, 1990

Trypanosoma congolense procyclins: unmasking cryptic major surface glycoproteins in procyclic forms

scientific article

Trypanosoma vivax: linkage of the mini-exon (spliced leader) and 5S ribosomal RNA genes.

scientific article

Unravelling the procyclin coat of Trypanosoma brucei.

scientific article published on March 1998

Zinc finger nuclease technology: A stable tool for high efficiency transformation in bloodstream form T. brucei

scientific article

‘GPEET’ procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427 ⬇️

scientific article published on September 1, 1997

List of works by Isabel Roditi

A Glycosylation Mutant of Trypanosoma brucei Links Social Motility Defects In Vitro to Impaired Colonization of Tsetse Flies In Vivo

A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei.

A family of stage-specific alanine-rich proteins on the surface of epimastigote forms of Trypanosoma brucei.

A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes

A transient CRISPR/Cas9 expression system for genome editing in Trypanosoma brucei

Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery

An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei

An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei.

Antagonistic effects of IL-4 and interferon-gamma (IFN-gamma) on inducible nitric oxide synthase expression in bovine macrophages exposed to gram-positive bacteria.

Bidirectional silencing of RNA polymerase I transcription by a strand switch region in Trypanosoma brucei.

Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei.

Characterisation and cellular localisation of a GPEET procyclin precursor in Trypanosoma brucei insect forms.

Cleavage of trypanosome surface glycoproteins by alkaline trypsin-like enzyme(s) in the midgut of Glossina morsitans

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Contributions of the procyclin 3' untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei.

Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: a dual role for polypyrimidine tracts in trypanosomes?

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes

Cycloheximide-mediated accumulation of transcripts from a procyclin expression site depends on the intergenic region.

DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide

Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host

Editing the Trypanosoma cruzi genome with zinc finger nucleases

Elements in the 3' untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation

Environmental sensing by African trypanosomes.

Expression of GARP, a major surface glycoprotein of Trypanosoma congolense, on the surface of Trypanosoma brucei: characterization and use as a selectable marker.

Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes.

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei

Flagellar cAMP signaling controls trypanosome progression through host tissues

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

Functional characterization of the trypanosome translational repressor SCD6

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

Glutamic acid/alanine-rich protein from Trypanosoma congolense is the functional equivalent of 'EP' procyclin from Trypanosoma brucei

Glycosylphosphatidylinositol-anchored surface molecules of Trypanosoma congolense insect forms are developmentally regulated in the tsetse fly.

Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel

Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei.

Identification and characterization of an acidic major surface glycoprotein from procyclic stage Trypanosoma congolense.

Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum

Identification of bracovirus particle proteins and analysis of their transcript levels at the stage of virion formation

Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei.

Interactions between trypanosomes and tsetse flies.

Lymphocytes infected with Theileria parva require both cell-cell contact and growth factor to proliferate.

MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans.

Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse

Molecular characterization of glycosomal NAD(+)-dependent glycerol 3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense.

Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei.

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway.

Nucleolar proteins regulate stage-specific gene expression and ribosomal RNA maturation in Trypanosoma brucei.

PSSA-2, a membrane-spanning phosphoprotein of Trypanosoma brucei, is required for efficient maturation of infection

Phosphorylation of GPEET procyclin is not necessary for survival of Trypanosoma brucei procyclic forms in culture and in the tsetse fly midgut.

Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane

Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surface

Production and characterisation of monoclonal antibodies specific for bovine interleukin-4

RNA-Seq analysis validates the use of culture-derived Trypanosoma brucei and provides new markers for mammalian and insect life-cycle stages.

Remote Sensing of Potential Biosignatures from Rocky, Liquid, or Icy (Exo)Planetary Surfaces.

Rodent-free cyclical transmission of Trypanosoma brucei brucei

Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei

Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei.

Sequence analysis of fowl plague virus mutant ts47 reveals a nonsense mutation in the NS1 gene.

Social motility of African trypanosomes is a property of a distinct life-cycle stage that occurs early in tsetse fly transmission.

Spliced leader trapping reveals widespread alternative splicing patterns in the highly dynamic transcriptome of Trypanosoma brucei.

Stable expression of biologically active recombinant bovine interleukin-4 in Trypanosoma brucei.

The Social Life of African Trypanosomes

The VSG-procyclin switch

The languages of parasite communication.

The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse

The regulation of procyclin expression in Trypanosoma bruceli: making or breaking the rules?

The repetitive microtubule-associated proteins MARP-1 and MARP-2 of Trypanosoma brucei.

The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei.

Trypanosoma (Nannomonas) simiae and T. (N.) godfreyi have genes encoding glutamic acid and alanine-rich proteins.

Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure.

Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters ⬇️

Trypanosoma congolense procyclins: unmasking cryptic major surface glycoproteins in procyclic forms

Trypanosoma vivax: linkage of the mini-exon (spliced leader) and 5S ribosomal RNA genes.

Unravelling the procyclin coat of Trypanosoma brucei.

Zinc finger nuclease technology: A stable tool for high efficiency transformation in bloodstream form T. brucei

‘GPEET’ procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427 ⬇️