List of works - Paul N. Mortenson

Allosteric inhibition of the neuropeptidase neurolysin.

scientific article

Assessing the lipophilicity of fragments and early hits ⬇️

scientific article published on May 26, 2011

DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.

scientific article

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor ⬇️

scientific article published on November 16, 2010

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

scientific article published on 24 December 2008

Diverse, high-quality test set for the validation of protein-ligand docking performance.

scientific article

Docking performance of fragments and druglike compounds.

scientific article published on 6 July 2011

Efficient exploration of chemical space by fragment-based screening

scientific article

Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA Ligase

scientific article

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

scientific article

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

scientific article published on 4 June 2015

Fragment-based approaches to the discovery of kinase inhibitors.

scientific article

Fragment-to-Lead Medicinal Chemistry Publications in 2016.

scientific article published on 31 October 2017

Fragment-to-Lead Medicinal Chemistry Publications in 2017

scientific article published on 21 November 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2018

scientific article published on 22 January 2020

Fragment-to-Lead Medicinal Chemistry Publications in 2019

scientific article published on 23 November 2020

Generation of Quantum Configurational Ensembles Using Approximate Potentials

scientific article published on 14 October 2021

Predicting "Hot" and "Warm" Spots for Fragment Binding

scientific article published on 4 April 2017

Protein-ligand docking against non-native protein conformers

scientific article

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction

scientific article published on 25 April 2019

List of works by Paul N. Mortenson

Allosteric inhibition of the neuropeptidase neurolysin.

Assessing the lipophilicity of fragments and early hits ⬇️

DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor ⬇️

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Diverse, high-quality test set for the validation of protein-ligand docking performance.

Docking performance of fragments and druglike compounds.

Efficient exploration of chemical space by fragment-based screening

Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA Ligase

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

Fragment-based approaches to the discovery of kinase inhibitors.

Fragment-to-Lead Medicinal Chemistry Publications in 2016.

Fragment-to-Lead Medicinal Chemistry Publications in 2017

Fragment-to-Lead Medicinal Chemistry Publications in 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2019

Generation of Quantum Configurational Ensembles Using Approximate Potentials

Predicting "Hot" and "Warm" Spots for Fragment Binding

Protein-ligand docking against non-native protein conformers

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction