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List of works by Fred Opperdoes

6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis

scientific article

A Feeling for the Cell: Christian de Duve (1917–2013)

scientific article

A chemostat study on proline uptake and metabolism of Leishmania donovani

scientific article published on September 1, 1992

A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes

scientific article published on 01 May 1984

A phosphoglycerate kinase-related gene conserved between Trypanosoma brucei and Crithidia fasciculata

scientific article published on January 1, 1992

A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana

scientific article

A rapid method for the isolation of intact glycosomes from Trypanosoma brucei by Percoll®-gradient centrifugation in a vertical rotor

scientific article published on 01 July 1981

A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei.

scientific article

Aerobic and anaerobic glucose metabolism of Phytomonas sp. isolated from Euphorbia characias.

scientific article

Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA and topoisomerases.

scientific article

An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order

scientific article published on 01 February 1996

An antimycin-sensitive cytochrome b component in beef-heart mitochondria

scientific article published on 01 April 1972

Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds

scientific article

Biochemical characterization of stage-specific isoforms of aspartate aminotransferases from Trypanosoma cruzi and Trypanosoma brucei

scientific article published on 28 May 2008

Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth

Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus

scientific article published on 10 July 2017

Characterisation of the two malate dehydrogenases from Phytomonas sp. Purification of the glycosomal isoenzyme.

scientific article published on October 1997

Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification

scientific article published on May 2004

Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei ⬇️

scientific article published on May 1, 1988

Characterization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems

scientific article published on July 2002

Cloning and characterization of the NAD-linked glycerol-3-phosphate dehydrogenases of Trypanosoma brucei brucei and Leishmania mexicana mexicana and expression of the trypanosome enzyme in Escherichia coli.

scientific article published on February 1996

Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli.

scientific article published on June 1994

Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids

scientific article published on 24 March 2016

Comparative genomics of Leishmania (Mundinia)

scientific article published on 11 October 2019

Comparative physiology of two protozoan parasites, Leishmania donovani and Trypanosoma brucei, grown in chemostats ⬇️

scientific article published on May 1, 1992

Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei

scientific article published on 24 November 2010

Comparative study of Leishmania mexicana and Trypanosoma brucei NAD-dependent glycerol-3-phosphate dehydrogenase.

scientific article

Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida.

scientific article

Complex I of Trypanosomatidae: does it exist?

scientific article published on 03 June 2008

Demonstration of glycosomes (microbodies) in the bodonid flagellate Trypanoplasma borelli (protozoa, kinetoplastida)

scientific article published on 01 August 1988

Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei

scientific article published on 23 December 2007

Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture.

scientific article

Enzymes of carbohydrate metabolism as potential drug targets.

scientific article

Evolution of energy metabolism and its compartmentation in Kinetoplastida

scientific article

Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids

scientific article published on 02 March 2020

Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase

scientific article published on 12 October 2009

Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei

scientific article published on 14 June 2005

Expression in Bacillus subtilis of the glycosomal glyceraldehyde-phosphate dehydrogenase gene from Trypanosoma brucei.

scientific article published in February 1992

Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania.

scientific article published on 29 March 2016

Genus-specific biochemical markers for Phytomonas spp

scientific article published on 01 December 1997

Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme.

scientific article published on September 1989

Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei. Comparison of the glycosomal and cytosolic isoenzymes.

scientific article published in February 1987

Glycerol kinase of Trypanosoma brucei. Cloning, molecular characterization and mutagenesis.

scientific article published on April 2000

Glycolysis as a target for the design of new anti-trypanosome drugs.

scientific article

Glycolysis in Trypanosoma brucei

scientific article published on 01 February 1980

Glycosomal glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma brucei and Trypanosoma cruzi: expression in Escherichia coli, purification, and characterization of the enzymes.

scientific article published on June 1995

Glycosomes may provide clues to the import of peroxisomal proteins.

scientific article published on July 1988

Horizontal gene transfer in trypanosomatids

scientific article

Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei

scientific article published on 01 February 1994

Impairment of growth of Leishmania donovani by Trypanosoma brucei during co-culture

article

Inhibition of glyceraldehyde-3-phosphate dehydrogenase by phosphorylated epoxides and alpha-enones.

scientific article

Inhibition of triosephosphate isomerase from Trypanosoma brucei with cyclic hexapeptides.

scientific article published on July 1992

Involvement of the glycosome of trypanosoma brucei in carbon dioxide fixation

scientific article published on 01 June 1982

Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase

scientific article published on August 2003

Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei. A comparison with the rabbit muscle and yeast enzymes

scientific article

Leptomonas pyrrhocoris: Genomic insight into Parasite's Physiology.

scientific article published in February 2018

Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani

scientific article published on 28 August 2015

Lipids Are the Preferred Substrate of the Protist Naegleria gruberi, Relative of a Human Brain Pathogen

scientific article published on 01 October 2018

Localization of Glycerol-3-Phosphate Oxidase in the Mitochondrion and Particulate NAD+-Linked Glycerol-3-Phosphate Dehydrogenase in the Microbodies of the Bloodstream Form of Trypanosoma brucei ⬇️

scientific article (publication date: June 1977)

Localization of hydrolases in cultured procyclic trypomastigotes of Trypanosoma brucei

scientific article published on 01 December 1981

Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei : The glycosome ⬇️

scientific article published on August 15, 1977

Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma brucei

scientific article published on 01 April 1984

Macrophage activation by polymeric nanoparticles of polyalkylcyanoacrylates: activity against intracellular Leishmania donovani associated with hydrogen peroxide production.

scientific article

Marinamoeba thermophila, a new marine heterolobosean amoeba growing at 50 degrees C.

scientific article

Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure

scientific article

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

scientific article

Metabolism of Leishmania: proven and predicted

scientific article published on 22 February 2007

Miconazole: an inhibitor of cyanide-insensitive respiration in Trypanosoma brucei.

scientific article published in January 1980

Molecular analysis of phosphoglycerate kinase in Trypanoplasma borreli and the evolution of this enzyme in kinetoplastida.

scientific article

Molecular characterisation of Trypanosoma brucei alkyl dihydroxyacetone-phosphate synthase.

scientific article

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase

scientific journal article

Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids

scientific article

Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila.

scientific article

Mutual adjustment of glucose uptake and metabolism in Trypanosoma brucei grown in a chemostat ⬇️

scientific article published on February 1, 1992

Myristate exchange. A second glycosyl phosphatidylinositol myristoylation reaction in African trypanosomes

scientific article published in Journal of Biological Chemistry

NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase

scientific article (publication date: 14 September 2001)

Naegleria gruberi metabolism

scientific article published on 16 June 2011

Natural products active against African trypanosomes: a step towards new drugs.

scientific article published on 5 May 2004

New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle.

scientific article

Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus

scientific article published on 26 April 2017

Novel pattern of editing regions in mitochondrial transcripts of the cryptobiid Trypanoplasma borreli

scientific article (publication date: November 1994)

Oligomycin sensitivity of the mitochondrial ATPase as a marker for fly transmissability and the presence of functional kinetoplast DNA in African trypanosomes ⬇️

scientific article published on January 1, 1976

Oramoeba fumarolia gen. nov., sp. nov., a new marine heterolobosean amoeboflagellate growing at 54 °C.

scientific article

Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant

scientific article published on 01 February 1993

Particle-Bound Enzymes in the Bloodstream Form of Trypanosoma brucei ⬇️

scientific article published on June 1, 1977

Plant-like traits associated with metabolism of Trypanosoma parasites

scientific article

Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei

scientific article published on 01 April 1987

Preliminary crystallographic studies of triosephosphate isomerase from the blood parasite Trypanosoma brucei brucei

scientific article published on 01 September 1984

Purification and characterisation of the phosphoglycerate kinase isoenzymes of Trypanosoma brucei expressed in Escherichia coli ⬇️

scientific article published on July 28, 1998

Pyruvate kinase of Leishmania mexicana mexicana. Cloning and analysis of the gene, overexpression in Escherichia coli and characterization of the enzyme.

scientific article published on March 1994

Pyruvate kinase of Trypanosoma brucei: overexpression, purification, and functional characterization of wild-type and mutated enzyme.

scientific article published on August 1998

Reactions involved in energy transfer in trypanosomes-I. Characterization of the mitochondrial adenine nucleotide translocator and the ATPase of Crithidia luciliae ⬇️

scientific article published on January 1, 1976

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

scientific article published on 14 June 2018

Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite ⬇️

scientific article published on September 1, 1988

Regulation of glycolysis in Trypanosoma brucei: hexokinase and phosphofructokinase activity

scientific article published on 01 March 1982

Retooling Leishmania metabolism: from sand fly gut to human macrophage

scientific article published on 20 September 2007

Role of acidic compartments in Trypanosoma brucei, with special reference to low-density lipoprotein processing.

scientific article published on April 1993

Secretion of Sucrase by Leishmania donovani

scientific article published on 01 May 1994

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

scientific article

Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase

scientific article published in July 2002

Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei

scientific article published on 01 November 1984

Specific inhibitors for the glycolytic enzymes of Trypanosoma brucei

scientific article published on 01 November 1995

Stimulation of Trypanosoma brucei pyruvate kinase by fructose 2,6-bisphosphate

scientific article published on 01 December 1985

Structure of the complex between trypanosomal triosephosphate isomerase and N‐hydroxy‐4‐phosphono‐butanamide: Binding at the active site despite an “open” flexible loop conformation ⬇️

scientific article published on December 1, 1992

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

scientific article

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

scientific article published on 01 September 1981

Subcellular Fractionation of Trypanosoma brucei Bloodstream Forms with Special Reference to Hydrolases ⬇️

scientific article published on March 1, 1980

Subcellular distribution and partial characterization of the cyclic AMP-binding proteins of Trypanosoma brucei

scientific article published on 01 February 1984

Subcellular distribution of adenylate cyclase, cyclic-AMP phosphodiesterase, protein kinases and phosphoprotein phosphatase in Trypanosoma brucei

scientific article published on 01 November 1982

Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma brucei.

scientific article published on September 1991

Synthesis and activity of inhibitors highly specific for the glycolytic enzymes from Trypanosoma brucei

scientific article published on 01 June 1993

The Glycosomal ATP‐Dependent Phosphofructokinase of Trypanosoma Brucei must have Evolved from an Ancestral Pyrophosphate‐Dependent Enzyme ⬇️

scientific article published on December 15, 1997

The Trypanosoma cruzi proteome.

scientific article

The dihydroxyacetonephosphate pathway for biosynthesis of ether lipids in Leishmania mexicana promastigotes.

scientific article published on October 1997

The effect of ATP on the apparent mid-point potentials of cytochrome b and cytochrome c in beef-heart mitochondria

scientific article published on 01 February 1972

The electrochemical proton gradient in the bloodstream form of Trypanosoma brucei is dependent on the temperature

scientific article published on October 1, 1992

The evolutionary origin of glycosomes.

scientific article

The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.

scientific article published on December 1995

The malate dehydrogenase isoforms from Trypanosoma brucei: subcellular localization and differential expression in bloodstream and procyclic forms

scientific article published on 21 October 2005

The multifunctional isopropyl alcohol dehydrogenase of Phytomonas sp. could be the result of a horizontal gene transfer from a bacterium to the trypanosomatid lineage

scientific article published on 9 July 2003

The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species

article

The phospholipases of Trypanosoma brucei bloodstream forms and cultured procyclics

scientific article published on 01 May 1982

The potential use of inhibitors of glycerol-3-phosphate oxidase for chemotherapy of African trypanosomiasis

scientific article published on February 15, 1976

The presence of four iron-containing superoxide dismutase isozymes in trypanosomatidae: characterization, subcellular localization, and phylogenetic origin in Trypanosoma brucei

scientific article

The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis

scientific article published on March 2002

The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants

scientific article

The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action

scientific article published on 01 September 1993

Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein

scientific article

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Trypanosoma brucei brucei: Antigenic stability of its LDL receptor and immunological cross-reactivity with the LDL receptor of the mammalian host

scientific article published on 01 February 1992

Trypanosoma brucei glycosomal glyceraldehyde-3-phosphate dehydrogenase genes are stage-regulated at the transcription level ⬇️

scientific article published on October 1, 1992

Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase ⬇️

scientific article published on March 17, 1998

Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach

scientific article published on October 2014

Uptake and turnover of glucose in Leishmania donovani.

scientific article published on August 1993

What Controls Glycolysis in Bloodstream FormTrypanosoma brucei?

scientific article published in Journal of Biological Chemistry

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