List of works - Alberto Massarotti

A Practical Synthesis of 5-Aroyl-1-aryltetrazoles Using an Ugi-Like 4-Component Reaction Followed by a Biomimetic Transamination

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

scientific article published on 30 July 2014

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives

scientific article published on 10 July 2019

Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.

scientific article

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

scientific article

Crystal structure of human nicotinic acid phosphoribosyltransferase.

scientific article published on 7 May 2015

De novo computer-aided design of novel antiviral agents

scientific article published on 01 January 2012

Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography.

scientific article published in July 2008

Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

scientific article published on 27 January 2015

Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity

scientific article published on 17 March 2020

Essential Medicinal Chemistry of Essential Medicines

scientific article published on 30 April 2020

Estrogenic Analogues Synthesized by Click Chemistry

scientific article published on 01 April 2007

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

scientific article

Haptic-driven applications to molecular modeling: state-of-the-art and perspectives

scientific article published on June 2012

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

scientific article published on 6 February 2017

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

scientific article published on 31 August 2017

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

scientific article published on 10 December 2021

Parallel synthesis of "click" chalcones as antitubulin agents.

scientific article

Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans

scientific article published on 10 January 2020

Rational Discovery of (+) (S) Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach.

scientific article published on 4 June 2018

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

scientific article published on 28 November 2010

Small molecule inhibitors of West Nile virus

scientific article

Solution-phase parallel synthesis and biological evaluation of combretatriazoles

scientific article

Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols

scientific article

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors

scientific article published on 15 May 2019

The metal face of protein tyrosine phosphatase 1B

scientific article

The tubulin colchicine domain: a molecular modeling perspective

scientific article published on 12 October 2011

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles

scientific article published on 27 November 2018

ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1,4-disubstituted triazoles

scientific article

Zinc ions modulate protein tyrosine phosphatase 1B activity

scientific article

List of works by Alberto Massarotti

A Practical Synthesis of 5-Aroyl-1-aryltetrazoles Using an Ugi-Like 4-Component Reaction Followed by a Biomimetic Transamination

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives

Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

Crystal structure of human nicotinic acid phosphoribosyltransferase.

De novo computer-aided design of novel antiviral agents

Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography.

Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents

Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity

Essential Medicinal Chemistry of Essential Medicines

Estrogenic Analogues Synthesized by Click Chemistry

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Haptic-driven applications to molecular modeling: state-of-the-art and perspectives

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

Parallel synthesis of "click" chalcones as antitubulin agents.

Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans

Rational Discovery of (+) (S) Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach.

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

Small molecule inhibitors of West Nile virus

Solution-phase parallel synthesis and biological evaluation of combretatriazoles

Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors

The metal face of protein tyrosine phosphatase 1B

The tubulin colchicine domain: a molecular modeling perspective

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles

ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1,4-disubstituted triazoles

Zinc ions modulate protein tyrosine phosphatase 1B activity