List of works - Ritva Tikkanen

A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia.

scientific article

AP-1 and AP-3 Mediate Sorting of Melanosomal and Lysosomal Membrane Proteins into Distinct Post-Golgi Trafficking Pathways

scientific article published on 09 April 2008

AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells

scientific article (publication date: February 2002)

Activation and oligomerization of aspartylglucosaminidase.

scientific article published in September 1998

Altered Expression of Ganglioside Metabolizing Enzymes Results in GM3 Ganglioside Accumulation in Cerebellar Cells of a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis.

scientific article published on 22 February 2018

Amlexanox provides a potential therapy for nonsense mutations in the lysosomal storage disorder Aspartylglucosaminuria

scientific article published on 13 December 2017

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells

scientific article

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases

scientific article

Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

scientific article published on 14 May 2008

Cholinergic transactivation of the EGFR in HaCaT keratinocytes stimulates a flotillin-1 dependent MAPK-mediated transcriptional response.

scientific article

Cytosolic and nuclear aggregation of the amyloid beta-peptide following its expression in the endoplasmic reticulum.

scientific article published on 3 October 2002

Detailed profile of cognitive dysfunction in children with aspartylglucosaminuria

scientific article published on 08 September 2019

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.

scientific article published on 5 August 2014

Dissecting the molecular function of reggie/flotillin proteins.

scientific article published on 4 May 2007

Endocytic trafficking of membrane-bound cargo: a flotillin point of view.

scientific article published on 11 July 2014

Epidermal growth factor receptor transactivation is required for mitogen-activated protein kinase activation by muscarinic acetylcholine receptors in HaCaT keratinocytes.

scientific article

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

scientific article

Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.

scientific article published on 9 January 2012

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase.

scientific article

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

scientific article

Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion

scientific article

Flotillins in receptor tyrosine kinase signaling and cancer.

scientific article published on 19 February 2014

Flotillins in the intercalated disc are potential modulators of cardiac excitability

scientific article published on 17 November 2018

Functional Analysis of the Ser149/Thr149 Variants of Human Aspartylglucosaminidase and Optimization of the Coding Sequence for Protein Production.

scientific article published on 26 March 2017

Functional Aspects of Membrane Association of Reggie/Flotillin Proteins ⬇️

scientific article published on December 1, 2011

Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.

scientific article published on 24 March 2009

Identification of Small Molecule Compounds for Pharmacological Chaperone Therapy of Aspartylglucosaminuria

scientific article (publication date: 23 November 2016)

Identification of structural elements in Nox1 and Nox4 controlling localization and activity.

scientific article

Immediate interaction between the nascent subunits and two conserved amino acids Trp34 and Thr206 are needed for the catalytic activity of aspartylglucosaminidase.

scientific article published on March 1995

Immortalized Human hTert/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris

scientific article published on 26 June 2019

Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.

scientific article published on 9 November 2013

Intracellular sorting of aspartylglucosaminidase: the role of N-linked oligosaccharides and evidence of Man-6-P-independent lysosomal targeting.

scientific article published on April 1995

Large-scale purification and preliminary X-ray diffraction studies of human aspartylglucosaminidase

scientific article published on 01 February 1996

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes

scientific article published on 27 June 2016

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression ⬇️

scientific article published on March 1, 2004

Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.

scientific article published on March 2013

Mitogen-Activated Protein Kinases: Functions in Signal Transduction and Human Diseases

scientific article published on 29 September 2019

Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2

scientific article published on 3 January 2012

Non-neuronal functions of the m2 muscarinic acetylcholine receptor.

scientific article published on 02 April 2013

Oncogenic breakdowns in endocytic adaptor proteins.

scientific article

Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells.

scientific article

Primary Folding of Aspartylglucosaminidase

scientific article published in Journal of Biological Chemistry

Random Splicing of Several Exons Caused by a Single Base Change in the Target Exon of CRISPR/Cas9 Mediated Gene Knockout.

scientific article published on 14 December 2016

Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.

scientific article published on 7 May 2007

Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo.

scientific article published on 5 June 2017

Regulation of ubiquitin-binding proteins by monoubiquitination

scientific article

Revisiting the endocytosis of the m2 muscarinic acetylcholine receptor

scientific article published on 12 May 2015

Role of dynamin and clathrin in the cellular trafficking of flotillins

scientific article

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

scientific article published on 04 April 2019

Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation

scientific article

Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase ⬇️

scientific article published on November 17, 1997

Statistical Permutation Test Reveals Progressive and Region-Specific Iron Accumulation in the Thalami of Children with Aspartylglucosaminuria

scientific article published on 27 September 2020

Succinic Semialdehyde Dehydrogenase Deficiency: An Update

scientific article published on 19 February 2020

Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1

scientific article published on 13 November 2020

Susceptibility-Weighted Imaging Findings in Aspartylglucosaminuria

scientific article published on 24 October 2019

The Dileucine Motif Within the Tail of MPR46 is Required for Sorting of the Receptor in Endosomes

scientific article published on 01 August 2000

The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes

scientific article

The receptor-bound N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts.

scientific article published on December 2002

Three-dimensional structure of human lysosomal aspartylglucosaminidase

scientific article

Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes

scientific article

Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN.

scientific article

List of works by Ritva Tikkanen

A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia.

AP-1 and AP-3 Mediate Sorting of Melanosomal and Lysosomal Membrane Proteins into Distinct Post-Golgi Trafficking Pathways

AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells

Activation and oligomerization of aspartylglucosaminidase.

Altered Expression of Ganglioside Metabolizing Enzymes Results in GM3 Ganglioside Accumulation in Cerebellar Cells of a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis.

Amlexanox provides a potential therapy for nonsense mutations in the lysosomal storage disorder Aspartylglucosaminuria

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases

Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

Cholinergic transactivation of the EGFR in HaCaT keratinocytes stimulates a flotillin-1 dependent MAPK-mediated transcriptional response.

Cytosolic and nuclear aggregation of the amyloid beta-peptide following its expression in the endoplasmic reticulum.

Detailed profile of cognitive dysfunction in children with aspartylglucosaminuria

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.

Dissecting the molecular function of reggie/flotillin proteins.

Endocytic trafficking of membrane-bound cargo: a flotillin point of view.

Epidermal growth factor receptor transactivation is required for mitogen-activated protein kinase activation by muscarinic acetylcholine receptors in HaCaT keratinocytes.

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase.

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

Flotillins directly interact with γ-catenin and regulate epithelial cell-cell adhesion

Flotillins in receptor tyrosine kinase signaling and cancer.

Flotillins in the intercalated disc are potential modulators of cardiac excitability

Functional Analysis of the Ser149/Thr149 Variants of Human Aspartylglucosaminidase and Optimization of the Coding Sequence for Protein Production.

Functional Aspects of Membrane Association of Reggie/Flotillin Proteins ⬇️

Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.

Identification of Small Molecule Compounds for Pharmacological Chaperone Therapy of Aspartylglucosaminuria

Identification of structural elements in Nox1 and Nox4 controlling localization and activity.

Immediate interaction between the nascent subunits and two conserved amino acids Trp34 and Thr206 are needed for the catalytic activity of aspartylglucosaminidase.

Immortalized Human hTert/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris

Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.

Intracellular sorting of aspartylglucosaminidase: the role of N-linked oligosaccharides and evidence of Man-6-P-independent lysosomal targeting.

Large-scale purification and preliminary X-ray diffraction studies of human aspartylglucosaminidase

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression ⬇️

Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.

Mitogen-Activated Protein Kinases: Functions in Signal Transduction and Human Diseases

Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2

Non-neuronal functions of the m2 muscarinic acetylcholine receptor.

Oncogenic breakdowns in endocytic adaptor proteins.

Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells.

Primary Folding of Aspartylglucosaminidase

Random Splicing of Several Exons Caused by a Single Base Change in the Target Exon of CRISPR/Cas9 Mediated Gene Knockout.

Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.

Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo.

Regulation of ubiquitin-binding proteins by monoubiquitination

Revisiting the endocytosis of the m2 muscarinic acetylcholine receptor

Role of dynamin and clathrin in the cellular trafficking of flotillins

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation

Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase ⬇️

Statistical Permutation Test Reveals Progressive and Region-Specific Iron Accumulation in the Thalami of Children with Aspartylglucosaminuria

Succinic Semialdehyde Dehydrogenase Deficiency: An Update

Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1

Susceptibility-Weighted Imaging Findings in Aspartylglucosaminuria

The Dileucine Motif Within the Tail of MPR46 is Required for Sorting of the Receptor in Endosomes

The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes

The receptor-bound N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts.

Three-dimensional structure of human lysosomal aspartylglucosaminidase

Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes

Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN.