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List of works by Lorena E. Brown

A Mouse Model for the Study of Contact-Dependent Transmission of Influenza A Virus and the Factors That Govern Transmissibility ⬇️

scientific article published on September 5, 2012

A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals

scientific article

A synthetic peptide-based polyoxime vaccine construct of high purity and activity

scientific article published on 01 October 1995

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

scholarly article

Abortive replication of influenza virus in mouse dendritic cells.

scientific article

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease ⬇️

scientific article (publication date: 2013)

Analysis of antibody-antigen and antibody-anti-cidiotypic antibody) cross-raeactivity using synthetic peptide probes

scientific article published on 01 March 1994

Antigenic determinants of influenza virus haemagglutinin. VI. Antigenic characterization of the oligosaccharide sidechains form HA1 of influenza virus haemagglutinins.

scientific article published in January 1981

Antigenic determinants of influenza virus hemagglutinin--IX. The carbohydrate side chains from an Asian strain.

scientific article

Antigenic determinants of influenza virus hemagglutinin. XII. the epitopes of a synthetic peptide representing the C-terminus of HA1.

scientific article published in December 1986

Antigenic variation in the influenza A virus nonstructural protein, NS1 ⬇️

scientific article published on October 15, 1983

Biological activity of monoclonal antibodies to operationally defined antigenic regions on the hemagglutinin molecule of A/Seal/Massachusetts/1 /80 (H7N7) influenza virus ⬇️

scientific article published on October 15, 1982

Characterization of H2 influenza virus hemagglutinin with monoclonal antibodies: Influence of receptor specificity ⬇️

scientific article published on October 30, 1984

Considerations for the rapid deployment of vaccines against H7N9 influenza.

scientific article

Control of pandemic (H1N1) 2009 influenza virus infection of ferret lungs by non-adjuvant-containing pandemic and seasonal vaccines

scientific article

Different arms of the adaptive immune system induced by a combination vaccine work in concert to provide enhanced clearance of influenza.

scientific article

Differential effect of CD8(+) and CD8(-) dendritic cells in the stimulation of secondary CD4(+) T cells.

scientific article published on April 2001

Enumeration and characterization of virus-specific B cells by multicolor flow cytometry.

scientific article

Establishment of functional influenza virus-specific CD8(+) T cell memory pools after intramuscular immunization.

scientific article published on 12 August 2015

Evaluation of vaccines for H5N1 influenza virus in ferrets reveals the potential for protective single-shot immunization

scientific article

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

scientific article published on 8 September 2017

Factors associated with transmission of influenza-like illness in a cohort of households containing multiple children

scientific article

Free radical induced polymerization of synthetic peptides into polymeric immunogens

scientific article published on 01 October 1997

Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys

scientific article published on 5 June 2015

Glycosylation of a synthetic peptide representing a T-cell determinant of influenza virus hemagglutinin results in loss of recognition by CD4+ T-cell clones.

scientific article

Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic

scientific article published in 2015

Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors.

scientific article published on 10 July 2008

ISCOM-based vaccines: the second decade.

scientific article

Immunopotentiation of humoral and cellular responses to inactivated influenza vaccines by two different adjuvants with potential for human use

article

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

scientific article published on 01 March 2011

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

scientific article published on 27 October 2015

Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation

scientific article published on 15 December 2015

Induction of multi-functional T cells in a phase I clinical trial of dendritic cell immunotherapy in hepatitis C virus infected individuals.

scientific article

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

scientific article published on 22 January 2010

Influenza NA and PB1 Gene Segments Interact during the Formation of Viral Progeny: Localization of the Binding Region within the PB1 Gene

scientific article

Influenza Virus Neuraminidase Structure and Functions

scientific article published on 29 January 2019

Influenza virus PB1 and neuraminidase gene segments can cosegregate during vaccine reassortment driven by interactions in the PB1 coding region.

scientific article

Influenza-induced inflammation drives pneumococcal otitis media.

scientific article published on 14 January 2013

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

scientific article published on 29 October 2012

Intranasal Administration of the TLR2 Agonist Pam2Cys Provides Rapid Protection against Influenza in Mice

scientific article published on 03 August 2012

Intranasal lipopeptide primes lung-resident memory CD8+ T cells for long-term pulmonary protection against influenza

scientific article published in March 2006

Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines

scientific article published on 31 October 2006

Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cells in the control of highly virulent influenza

scientific article

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

scientific article published on 18 December 2017

Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus.

scientific article published in February 2003

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

article

Modulation of CD4+ T-Cell Recognition of Influenza Hemagglutinin by Carbohydrate Side Chains Located Outside a T-Cell Determinant

scientific article published on 01 January 1993

Mouse Saliva Inhibits Transit of Influenza Virus to the Lower Respiratory Tract by Efficiently Blocking Influenza Virus Neuraminidase Activity.

scientific article

Murine helper T lymphocyte response to influenza virus: recognition of haemagglutinin by subtype-specific and cross-reactive T cell clones.

scientific article published in September 1985

Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

article

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

scientific article published on 01 January 2010

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

scientific article (publication date: 2010)

Pre-pandemic and pandemic influenza vaccines.

scientific article

Predicting Disease Severity and Viral Spread of H5N1 Influenza Virus in Ferrets in the Context of Natural Exposure Routes.

scientific article published on 9 December 2015

Prevention and treatment of influenza with hyperimmune bovine colostrum antibody

scientific article (publication date: 26 October 2010)

Prior population immunity reduces the expected impact of CTL-inducing vaccines for pandemic influenza control.

scientific article published on 26 March 2015

Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes.

scientific article

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: extending the potential of broadly cross-protecting epitopes.

scientific article

Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?

scientific article

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

scientific article

Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin

scientific article published on 29 October 2011

Reducing the impact of influenza-associated secondary pneumococcal infections.

scientific article published on 2 July 2015

Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development

scientific article published in October 2009

Salivary Blockade Protects the Lower Respiratory Tract of Mice from Lethal Influenza Virus Infection

scientific article published on 26 April 2017

Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells

scientific article published on 05 February 2009

Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses

scientific article

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

scholarly article

Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.

scientific article published on 10 November 2006

Targeting CD45RB alters T cell migration and delays viral clearance.

scientific article published on 16 December 2005

Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections

scientific article published on 24 August 2008

The antigenic and immunogenic properties of synthetic peptide immunocontraceptive vaccine candidates based on gamete antigens

scientific article published on 01 October 1999

The cell surface mucin MUC1 limits the severity of influenza A virus infection.

scientific article published on 22 March 2017

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

scientific article published on 11 April 2011

The role of adjuvants in vaccines for seasonal and pandemic influenza.

scientific article

The role of neutrophils during mild and severe influenza virus infections of mice

scientific article

The source of the PB1 gene in influenza vaccine reassortants selectively alters the hemagglutinin content of the resulting seed virus.

scientific article published on 6 March 2013

The structure of the influenza A virus genome

scientific article published on 22 July 2019

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

scientific article published on 2 November 2016

Totally synthetic lipid-containing polyoxime peptide constructs are potent immunogens

scientific article published on 01 January 2000

Universal immunity to influenza must outwit immune evasion

scientific article

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

scientific article published on 14 June 2012

Using bioluminescent imaging to investigate synergism between Streptococcus pneumoniae and influenza A virus in infant mice

scientific article

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