List of works by Rahul M. Kohli

A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage.

scientific article published on 21 August 2017

A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

scientific article published on 26 June 2009

A vitamin-C-derived DNA modification catalysed by an algal TET homologue

scientific article published on 01 May 2019

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

scientific article published on 8 July 2012

APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription

scientific article published on 28 February 2013

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.

scientific article published on 2 May 2017

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

scientific article published on 18 December 2018

Biomimetic synthesis and optimization of cyclic peptide antibiotics

scientific article (publication date: 8 August 2002)

Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules.

scientific article published in June 2003

DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia

scientific article

Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.

scientific article

Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent.

scientific article

Exploiting Substrate Promiscuity To Develop Activity-Based Probes for Ten-Eleven Translocation Family Enzymes

scientific article published on 11 December 2018

Grand Challenge Commentary: The chemistry of a dynamic genome ⬇️

scientific article published on 01 December 2010

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

scientific article published on 13 July 2020

High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.

scientific article

Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection.

scientific article

Improving the Fluorescent Probe Acridonylalanine Through a Combination of Theory and Experiment

scientific article published on 22 February 2018

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.

scientific article published on 24 December 2017

Introduction: Genome Modifying Mechanisms

scientific article published on 01 October 2016

Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

scientific article

Mechanisms for targeted, purposeful mutation revealed in an APOBEC-DNA complex.

scientific article published in February 2017

Molecular biology. Demystifying DNA demethylation

scientific article published on 01 September 2011

Molecular targeting of mutagenic AID and APOBEC deaminases

scientific article published on 15 November 2013

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.

scientific article

Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network.

scientific article

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

scientific article published on 8 October 2018

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.

scientific article published on 13 August 2013

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

article

Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.

scientific article

Selectivity and Promiscuity in TET-mediated oxidation of 5-methylcytosine in DNA and RNA

scientific article published on 14 November 2018

Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.

scientific article published in January 2010

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells

scientific article published on 07 May 2021

Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis.

scientific article published on 8 May 2014

Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

scientific article

Systematic Evaluation of Soluble Protein Expression Using a Fluorescent Unnatural Amino Acid Reveals No Reliable Predictors of Tolerability

scientific article published on 20 September 2018

Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

scientific article published on July 2016

TET enzymes, TDG and the dynamics of DNA demethylation.

scientific article

TET-mediated 5-methylcytosine oxidation in tRNA promotes translation

scientific article published on 16 November 2020

Targets for Combating the Evolution of Acquired Antibiotic Resistance

scientific article published on 5 June 2015

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.

scientific article published on 06 January 2016

The Kinetic and Molecular Basis for the Interaction of LexA and Activated RecA Revealed by a Fluorescent Amino Acid Probe

scientific article published on 05 February 2020

The SOS Response Mediates Sustained Colonization of the Mammalian Gut

scientific article published on 24 January 2019

The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation

scientific article published on 24 September 2008

The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

scientific article published on 31 October 2011

The expanding scope and impact of epigenetic cytosine modifications.

scientific article published on 14 June 2016

The oxidative half-reaction of Old Yellow Enzyme. The role of tyrosine 196

scientific article published on 01 December 1998

Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

scientific article published in September 2004

When to think of zebras.

scientific article published in May 2009

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