List of works - Boris Turk

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

scientific article

A pre-steady-state kinetic analysis of substrate binding to human recombinant deoxycytidine kinase: a model for nucleoside kinase action

scientific article published on 01 June 1999

A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

scientific article

A role for stefin B (cystatin B) in inflammation and endotoxemia

scientific article

Acidic pH as a physiological regulator of human cathepsin L activity

scientific article published in February 1999

Activation processing of cathepsin H impairs recognition by its propeptide.

scientific article published in September 2005

Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K.

scientific article published in July 2005

Autophagy in protists.

scientific article published on February 2011

B cell receptor-mediated nuclear fragmentation proceeds in WEHI 231 cells in the absence of detectable DEVDase and FRase activity.

scientific article published in October 2003

Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi

scientific article

Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells

scientific article published on 11 May 2006

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

scientific article published on 03 May 2016

Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence

scientific journal article

Cathepsin nanofiber substrates as potential agents for targeted drug delivery

scientific article

Crystallographic and fluorescence studies of ligand binding to N-carbamoylsarcosine amidohydrolase from Arthrobacter sp

scientific article published on 01 October 1996

Current trends and challenges in proteomic identification of protease substrates.

scientific article

Cystatin F regulates proteinase activity in IL-2-activated natural killer cells.

scientific article published in January 2014

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

scientific article published on 20 March 2019

Cysteine cathepsin activity regulation by glycosaminoglycans

scientific article published on 21 December 2014

Cysteine cathepsins and extracellular matrix degradation.

scientific article published on 27 March 2014

Cysteine cathepsins and their potential in clinical therapy and biomarker discovery

scientific article published on 24 March 2014

Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells

scientific article published on 4 May 2009

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond.

scientific article published on 31 January 2018

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.

scientific article

Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells.

scientific article published on November 2007

DNA accelerates the inhibition of human cathepsin V by serpins

scientific article

Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways

scientific article published on 23 January 2014

Detecting cathepsin activity in human osteoarthritis via activity-based probes.

scientific article published on 20 March 2015

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.

scientific article

Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

scientific article published on 18 October 2007

Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a β-like variant in baculovirus-infected insect cells ⬇️

scientific article published on August 15, 1995

Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma

scientific article published on 5 May 2015

Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S.

scientific article published on 09 March 2015

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation

scientific article published on 19 October 2010

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

scientific article

Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

High-molecular-weight kininogen binds two molecules of cysteine proteinases with different rate constants

scientific article

Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells

scientific article

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

scientific article

In vivo imaging of Lactococcus lactis, Lactobacillus plantarum and Escherichia coli expressing infrared fluorescent protein in mice

scientific article

In vivo imaging of mouse tumors by a lipidated cathepsin S substrate

scientific article published on 30 May 2014

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

scientific article published in August 2003

Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea

scientific article published on 03 June 2016

Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis

scientific article published on 22 April 2020

Lysosomal membrane permeabilization in cell death: concepts and challenges.

scientific article published on 28 June 2014

Lysosomal pathways to cell death and their therapeutic applications.

scientific article

Lysosomes in programmed cell death pathways: from initiators to amplifiers

scientific article published on 01 March 2017

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

scientific article published on 20 January 2011

Measuring Cysteine Cathepsin Activity to Detect Lysosomal Membrane Permeabilization

scientific article published on 02 May 2016

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium

scientific article published on 25 July 2013

Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity

scientific article

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

scientific article published on August 2010

Oligomeric Structure and Substrate Induced Inhibition of Human Cathepsin C ⬇️

scientific article published on September 15, 1995

Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy.

scientific article

Polyalanine tracts directly induce the release of cytochrome c, independently of the mitochondrial permeability transition pore, leading to apoptosis.

scientific article published on 22 May 2009

Protean proteases: at the cutting edge of lung diseases

scientific article published on 8 February 2017

Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain.

scientific article published on 21 July 2017

Protease signalling in cell death: caspases versus cysteine cathepsins.

scientific article published on 25 May 2007

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

scientific article published on 17 March 2008

SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.

scientific article published on 17 December 2013

Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells

scientific article published on 30 June 2017

Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe.

scientific article

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

scientific article

Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

scientific article published on 01 June 2019

Stefin B interacts with histones and cathepsin L in the nucleus

scientific article

Strategies for Assaying Lysosomal Membrane Permeabilization

scientific article published on 01 June 2016

Studying Lysosomal Membrane Permeabilization by Analyzing the Release of Preloaded BSA-Gold Particles into the Cytosol.

scientific article published in June 2016

Targeting proteases: successes, failures and future prospects

scientific article

The Acute Phase Response Is a Prominent Renal Proteome Change in Sepsis in Mice

scientific article published on 27 December 2019

The Use of Lysosomotropic Dyes to Exclude Lysosomal Membrane Permeabilization.

scientific article

The endolysosomal system in cell death and survival

scientific article

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

scientific article published on 19 January 2008

Tumor Necrosis Factor-α Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation

scientific article

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.

scientific article

Upregulation of Mitochondrial Redox Sensitive Proteins in LPS-Treated Stefin B-Deficient Macrophages

scientific article published on 21 November 2019

Use of Non-Natural Amino Acids for the Design and Synthesis of a Selective, Cell-Permeable MALT1 Activity-Based Probe

scientific article published on 09 April 2020

Vito Turk--30 years of research on cysteine proteases and their inhibitors.

scientific article published in June 2003

List of works by Boris Turk

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

A pre-steady-state kinetic analysis of substrate binding to human recombinant deoxycytidine kinase: a model for nucleoside kinase action

A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

A role for stefin B (cystatin B) in inflammation and endotoxemia

Acidic pH as a physiological regulator of human cathepsin L activity

Activation processing of cathepsin H impairs recognition by its propeptide.

Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K.

Autophagy in protists.

B cell receptor-mediated nuclear fragmentation proceeds in WEHI 231 cells in the absence of detectable DEVDase and FRase activity.

Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi

Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence

Cathepsin nanofiber substrates as potential agents for targeted drug delivery

Crystallographic and fluorescence studies of ligand binding to N-carbamoylsarcosine amidohydrolase from Arthrobacter sp

Current trends and challenges in proteomic identification of protease substrates.

Cystatin F regulates proteinase activity in IL-2-activated natural killer cells.

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

Cysteine cathepsin activity regulation by glycosaminoglycans

Cysteine cathepsins and extracellular matrix degradation.

Cysteine cathepsins and their potential in clinical therapy and biomarker discovery

Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond.

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.

Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells.

DNA accelerates the inhibition of human cathepsin V by serpins

Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways

Detecting cathepsin activity in human osteoarthritis via activity-based probes.

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.

Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a β-like variant in baculovirus-infected insect cells ⬇️

Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma

Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S.

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation

Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice

Guidelines for the use and interpretation of assays for monitoring autophagy

High-molecular-weight kininogen binds two molecules of cysteine proteinases with different rate constants

Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

In vivo imaging of Lactococcus lactis, Lactobacillus plantarum and Escherichia coli expressing infrared fluorescent protein in mice

In vivo imaging of mouse tumors by a lipidated cathepsin S substrate

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea

Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis

Lysosomal membrane permeabilization in cell death: concepts and challenges.

Lysosomal pathways to cell death and their therapeutic applications.

Lysosomes in programmed cell death pathways: from initiators to amplifiers

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

Measuring Cysteine Cathepsin Activity to Detect Lysosomal Membrane Permeabilization

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium

Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity

Nuclear cysteine cathepsin variants in thyroid carcinoma cells

Oligomeric Structure and Substrate Induced Inhibition of Human Cathepsin C ⬇️

Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy.

Polyalanine tracts directly induce the release of cytochrome c, independently of the mitochondrial permeability transition pore, leading to apoptosis.

Protean proteases: at the cutting edge of lung diseases

Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain.

Protease signalling in cell death: caspases versus cysteine cathepsins.

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.

Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells

Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe.

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

Stefin B interacts with histones and cathepsin L in the nucleus

Strategies for Assaying Lysosomal Membrane Permeabilization

Studying Lysosomal Membrane Permeabilization by Analyzing the Release of Preloaded BSA-Gold Particles into the Cytosol.

Targeting proteases: successes, failures and future prospects

The Acute Phase Response Is a Prominent Renal Proteome Change in Sepsis in Mice

The Use of Lysosomotropic Dyes to Exclude Lysosomal Membrane Permeabilization.

The endolysosomal system in cell death and survival

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

Tumor Necrosis Factor-α Induced Apoptosis in U937 Cells Promotes Cathepsin D-Independent Stefin B Degradation

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.

Upregulation of Mitochondrial Redox Sensitive Proteins in LPS-Treated Stefin B-Deficient Macrophages

Use of Non-Natural Amino Acids for the Design and Synthesis of a Selective, Cell-Permeable MALT1 Activity-Based Probe

Vito Turk--30 years of research on cysteine proteases and their inhibitors.