List of works - Luis Martinez-Sobrido

7a protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase

scientific article published on January 2006

A Bivalent Live-Attenuated Vaccine for the Prevention of Equine Influenza Virus

scientific article published on 11 October 2019

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

scientific article published on 18 April 2020

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

scientific article published on 25 February 2020

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

scientific article published on 24 March 2020

A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters

scientific article published on 11 August 2021

A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses.

scientific article published on 11 July 2017

A live-attenuated influenza vaccine for H3N2 canine influenza virus.

scientific article published on 3 February 2017

A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery

scientific article

An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

scientific article published on 07 October 2018

An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening

scientific article published on 01 September 2020

An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein

scientific article

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins

scientific article published on 16 November 2017

Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication

scientific article published on 27 July 2016

Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines

scientific article published on 13 May 2015

Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

scientific article published on 24 April 2012

Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

scientific article published on 23 May 2012

Arenavirus reverse genetics for vaccine development

scientific article published on 30 January 2013

Avian Interferons and Their Antiviral Effectors.

scientific article published on 31 January 2017

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

scientific article published on 11 April 2018

Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines

scientific article

Characterizing Emerging Canine H3 Influenza Viruses

scientific article published on 14 April 2020

Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage.

scientific article published on 14 December 2017

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines

scientific article published on 10 October 2019

Comparison of serum hemagglutinin and neuraminidase inhibition antibodies after 2010-2011 trivalent inactivated influenza vaccination in healthcare personnel

scientific article

Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA).

scientific article

Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response

scientific article

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

scientific article

Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation

scientific article

D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis

scientific article

Development and applications of single-cycle infectious influenza A virus (sciIAV).

scientific article published on 25 July 2015

Development of Recombinant Arenavirus-Based Vaccines.

scientific article published on January 2017

Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine

scientific article

Development of live-attenuated arenavirus vaccines based on codon deoptimization

scientific article

Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein.

scientific article

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

scientific article published on 24 July 2020

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

scientific article (publication date: 2008)

Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines.

scientific article published in June 2015

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

scientific article

Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses

scientific article

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern

scientific article published on 04 June 2021

Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice

scientific article published on 26 January 2022

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

scientific article published on 21 June 2017

Generation of Recombinant Influenza Virus from Plasmid DNA ⬇️

scientific article published on August 3, 2010

Generation of recombinant arenavirus for vaccine development in FDA-approved Vero cells.

scientific article published on August 2013

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response

scientific article

Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies

scientific article

High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine

scientific article

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

scientific article

Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein

scientific article (publication date: 2011)

Identification of Inhibitors of ZIKV Replication

scientific article published on 18 September 2020

Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus

scientific article

Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches

scientific article published on February 2007

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus

scientific article

Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies

scientific article

Influenza A Virus Studies in a Mouse Model of Infection.

scientific article published on 7 September 2017

Influenza A and B virus intertypic reassortment through compatible viral packaging signals.

scientific article

Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development

scientific article

Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach

scientific article

Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR

scientific article

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation

scientific article published on 13 November 2019

Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

scientific article

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

scientific article

Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor.

scientific article published on 6 November 2013

Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

scientific article

Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels

scientific article published on 25 April 2007

Inhibition of the type I interferon antiviral response during arenavirus infection

scientific article

Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

scientific article

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus

scientific article published on 21 June 2017

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

scientific article published on 30 November 2020

Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines

scientific article published on 23 April 2007

Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS.

scientific article published on April 2015

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

scientific article published on 01 December 2021

Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring

scientific article

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection

scientific article published on 12 November 2008

Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins

article

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

scientific article

Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge.

scientific article published in August 2004

Multiple anti-interferon actions of the influenza A virus NS1 protein

scientific article

Murine coronavirus delays expression of a subset of interferon-stimulated genes

scientific article published on 31 March 2010

Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture

scientific article

Mutations at highly conserved residues in influenza A(H1N1)pdm09 virus affect neuraminidase activity

scientific article

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

scientific article published on 21 December 2016

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

scientific article published on 17 August 2016

New Advances on Zika Virus Research

scientific article published on 14 March 2019

Novel Approaches for The Development of Live Attenuated Influenza Vaccines

article

Novel strategies for development of hemorrhagic fever arenavirus live-attenuated vaccines.

scientific article published on 27 April 2016

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

scientific article published on 05 November 2021

Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus.

scientific article published on 10 August 2017

Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

scientific article published on 7 September 2017

Peptides Derived from the Tight Junction Protein CLDN1 Disrupt the Skin Barrier and Promote Responsiveness to an Epicutaneous Vaccine

scientific article published on 02 August 2019

Plasmid-Based Reverse Genetics of Influenza A Virus

scientific article published on January 2017

Protection against lethal influenza with a viral mimic

scientific article published on 29 May 2013

Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector

scientific article

Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines.

scientific article published on 27 April 2016

Recombinant influenza virus vectors

Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals

scientific article

Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene

scholarly article

Replication-Competent Influenza A Viruses Expressing Reporter Genes

scientific article

Replication-Competent Influenza A and B Viruses Expressing a Fluorescent Dynamic Timer Protein for In Vitro and In Vivo Studies

scientific article published on 25 January 2016

Replication-competent fluorescent-expressing influenza B virus

scientific article

Replication-competent influenza A viruses expressing a red fluorescent protein

scientific article

Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses

scientific article

Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome

scientific article published on 25 September 2020

Rescue of recombinant Newcastle disease virus from cDNA.

scientific article published on 11 October 2013

Restless legs syndrome in non-dialysis renal patients: is it really that common?

scientific article

Reverse Genetic Approaches for the Generation of Recombinant Zika Virus

scientific article published on 31 October 2018

Reverse Genetics Approaches for the Development of Influenza Vaccines

scientific article

Reverse Genetics Approaches to Control Arenavirus.

scientific article published on January 2016

Reverse Genetics of Influenza B Viruses

scientific article

Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function

scientific article published on 18 January 2012

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

scientific article

Structural basis of RNA cap modification by SARS-CoV-2

scientific article published on 24 July 2020

Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine

scholarly article by Luis Martinez-Sobrido published in October 2018

Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine

scientific article published on 07 December 2016

The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response

scientific article published on 5 October 2011

The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

scientific article

The human cytomegalovirus UL26 protein antagonizes NF-κB activation

scientific article

The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

scientific article

The intracellular sites of early replication and budding of SARS-coronavirus

scholarly article by Silke Stertz published in May 2007

The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?

scientific article

Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor

article by N. Buettner et al published 7 October 2009 in Journal of General Virology

Thogoto virus ML protein suppresses IRF3 function

scientific article published in January 2005

Transcriptional role of p53 in interferon-mediated antiviral immunity.

scientific article

Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies

scientific article

Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus

scientific article

Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses

scientific article published on December 2010

List of works by Luis Martinez-Sobrido

7a protein of severe acute respiratory syndrome coronavirus inhibits cellular protein synthesis and activates p38 mitogen-activated protein kinase

A Bivalent Live-Attenuated Vaccine for the Prevention of Equine Influenza Virus

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters

A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses.

A live-attenuated influenza vaccine for H3N2 canine influenza virus.

A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery

An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening

An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins

Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication

Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines

Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

Arenavirus reverse genetics for vaccine development

Avian Interferons and Their Antiviral Effectors.

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines

Characterizing Emerging Canine H3 Influenza Viruses

Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage.

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines

Comparison of serum hemagglutinin and neuraminidase inhibition antibodies after 2010-2011 trivalent inactivated influenza vaccination in healthcare personnel

Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA).

Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation

D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis

Development and applications of single-cycle infectious influenza A virus (sciIAV).

Development of Recombinant Arenavirus-Based Vaccines.

Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine

Development of live-attenuated arenavirus vaccines based on codon deoptimization

Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines.

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern

Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

Generation of Recombinant Influenza Virus from Plasmid DNA ⬇️

Generation of recombinant arenavirus for vaccine development in FDA-approved Vero cells.

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response

Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies

High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein

Identification of Inhibitors of ZIKV Replication

Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus

Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus

Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies

Influenza A Virus Studies in a Mouse Model of Infection.

Influenza A and B virus intertypic reassortment through compatible viral packaging signals.

Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development

Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach

Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation

Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor.

Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels

Inhibition of the type I interferon antiviral response during arenavirus infection

Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines

Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS.

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT₂A and mGlu₂ receptors in the adult offspring

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection

Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge.