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List of works by Shin-ichi Tsunoda

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy

scientific article published on 17 December 2015

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

scientific article published on 20 May 2019

Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials

scientific article published on 22 September 2010

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

scientific article

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

scientific article

Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

scientific article published on 04 January 2012

Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells

scientific article published on 26 September 2012

Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection

scientific article

Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells ⬇️

scientific article published on April 4, 2012

Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant on established murine collagen-induced arthritis

scientific article published on 01 January 2011

Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats

scientific article published on 01 July 1997

Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant

scientific article

Arsenic trioxide inhibits human t cell-lymphotropic virus-1-induced syncytiums by down-regulating gp46.

scientific article published in July 2009

Asian dust particles induce macrophage inflammatory responses via mitogen-activated protein kinase activation and reactive oxygen species production.

scientific article

Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells

scientific article published on 01 February 1999

Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency

scientific article published on 01 October 1997

Carbon Nanomaterials: Efficacy and Safety for Nanomedicine.

scientific article published on 21 February 2012

Cell array coupled with laser scanning cytometry allows easy analysis of changes in cyclin expression during the cell cycle. An application of cell array system.

scientific article

Comparative study on transduction and toxicity of protein transduction domains.

scientific article published on 28 January 2008

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

scientific article

Creation of TNFR1-selective antagonist and its therapeutic effects

scientific article

Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy

scientific article

Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.

scientific article

Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system

scientific article

Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

scientific article

Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex

scientific article published on 26 February 2009

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

scientific article published on 26 June 2015

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.

scientific article published on April 2004

Development of a novel DDS for site-specific PEGylated proteins

scientific article

Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins ⬇️

scientific article published on October 8, 2010

Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice

scientific article published on 06 March 2012

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages.

scientific article published on 22 July 2011

Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages.

scientific article published on 18 January 2011

Eph receptor A10 has a potential as a target for a prostate cancer therapy.

scientific article

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

scientific article

Evaluation of silica nanoparticle binding to major human blood proteins.

scientific article published on 11 December 2014

Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.

scientific article

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists

scientific article

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning.

scientific article

Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3.

scientific article published on 17 December 2014

Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2.

scientific article

Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles

scientific article published on 8 October 2012

Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.

scientific article published on 31 March 2009

Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors

scientific article published on 11 May 2015

Identification of new candidates as mucosal vaccine adjuvant in TNF family cytokines

scientific article published on 01 January 2011

In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha

scientific article published on 01 February 2000

Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.

scientific article

Intestinal absorption and biological effects of orally administered amorphous silica particles.

scientific article

Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

scientific article published on 20 August 2013

LIGHT protein suppresses tumor growth by augmentation of immune response.

scientific article

Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung ⬇️

scientific article published on January 25, 2011

Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

scientific article published on 12 September 2013

Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation ⬇️

scientific article published on August 25, 2011

Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif.

scientific article

Molecular design of conjugated tumor necrosis factor-alpha: synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha

scientific article published on 01 April 1999

Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice

scientific article published on 01 September 2000

Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy.

scientific article

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

scientific article published on 13 August 2009

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.

scientific article

Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.

scientific article

Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice.

scientific article published on 4 March 2011

Promotion of optimized protein therapy by bioconjugation as a polymeric DDS.

scientific article

Quality enhancement of the non-immune phage scFv library to isolate effective antibodies

scientific article published in July 2006

Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.

scientific article

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

scientific article published on 19 November 2006

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

scientific article published on 22 May 2007

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.

scientific article published on March 2004

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

scientific article published on 03 April 2011

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

scientific article published on 26 March 2008

Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro.

scientific article

Solution of the structure of the TNF-TNFR2 complex

scientific article

Structure-activity relationship of T-cell receptors based on alanine scanning

scientific article published on 31 October 2011

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

scientific article

Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells

scientific article

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application ⬇️

scientific article published on January 22, 2011

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

scientific article published on 4 May 2009

The targeting of anionized polyvinylpyrrolidone to the renal system.

scientific article published in August 2004

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

scientific article published on 23 September 2008

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

scientific article published on 17 September 2009

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

scientific article published on July 2004

The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses

scientific article published on 30 July 2009

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.

scientific article

Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy

scientific article published on 01 July 1999

[Antibody engineering for next-generation biodrug development]

scientific article published on 01 January 2013

[Application of nanomaterials for drug innovation and their risks]

scientific article published on 01 December 2008

[Development of a technology platform for novel drug discovery aimed at regulating biological function]

scientific article published on 01 January 2010

[Transdermal penetration and biodistribution of nanomaterials and their acute toxicity in vivo]

scientific article published on 01 February 2011

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