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List of works by Karuppiah Muthumani

A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates

scientific article

A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.

scientific article

A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus

scientific article published on 29 October 2020

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

scientific article

Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides.

scientific article published in February 2010

Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium.

scientific article published on 24 March 2013

Chikungunya: a potentially emerging epidemic?

scientific article

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity

scientific article published on 25 March 2014

Complete Regression of Established Subcutaneous B16 Murine Melanoma Tumors after Delivery of an HIV-1 Vpr-Expressing Plasmid by in Vivo Electroporation

article

Cross-reactive antibodies facilitate innate sensing of dengue and Zika viruses

scientific article published in 2022

DNA vaccines for targeting bacterial infections.

scientific article published on July 2010

DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo

scientific article published on 18 December 2007

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo

scientific article

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

scientific article

HIV-1 Viral Protein-R (VPR) Protects against Lethal Superantigen Challenge While Maintaining Homeostatic T Cell Levels in Vivo

article

HIV-1 Vpr and anti-inflammatory activity

scientific article

HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells

scientific article (publication date: 4 October 2002)

HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro

article

HIV-1 viral genes and mitochondrial apoptosis.

scientific article published on 12 July 2008

HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells

scientific article

Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism

scientific article (publication date: August 2005)

Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism

scientific article published on 17 September 2008

Immunogenicity of a DNA vaccine candidate for COVID-19

scientific article published on 20 May 2020

Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45

scientific article

Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus

scientific article

In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia.

scientific article

Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway

scientific article

Mechanism of HIV-1 viral protein R-induced apoptosis ⬇️

scientific article published on May 9, 2003

Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination

scientific article (publication date: November 2011)

Molecular characterization of Chikungunya virus during an outbreak in South India.

scientific article published on October 2010

Nonstructural protein 2 (nsP2) of Chikungunya virus (CHIKV) enhances protective immunity mediated by a CHIKV envelope protein expressing DNA Vaccine

scientific article published on February 2013

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab.

scientific article published on 17 September 2013

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo.

scientific article published on 22 October 2009

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

scientific article published on 29 July 2015

Protective immunity by an engineered DNA vaccine for Mayaro virus

scientific article published in February 2019

Protocols for Developing Novel Chikungunya Virus DNA Vaccines.

scientific article published on January 2016

REDD1 Is Essential for Optimal T Cell Proliferation and Survival

scientific article published on 24 August 2015

RETRACTED ARTICLE: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

retracted scholarly article

Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection.

scientific article published in August 2011

SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques

article

Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects

scientific article

Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo ⬇️

scientific article published on 07 September 2011

Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants.

scientific article published on 4 November 2013

The HIV-1 Accessory Gene vpr Can Inhibit Antigen-Specific Immune Function

article

The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest.

scientific article

The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1

scientific article

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

article

Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice.

scientific article published on November 2012

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