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List of works by Santiago Ramon y Cajal

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

scientific article (publication date: 15 August 2007)

A controlled study of treatment with recombinant interferon alpha in chronic hepatitis B virus infection: induction and maintenance schedules.

scientific article

A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers

scientific article published on 26 October 2010

A meningiomatous perineurial tumour located in the mesentery. An ultrastructural and immunohistochemical study

scientific article published on 01 February 2006

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

scientific article

A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer's diseases in three patients with divergent clinical phenotypes

scientific article published on 05 July 2012

A rare case of malignant solitary fibrous tumor of the spinal cord

scientific article

A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas

scientific article published on 09 August 2019

ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells.

scientific article

Abstract 1053: Interplay of YB-1 and IL-6 in the acquisition of EMT-like characteristics

Actualización de la recomendación para la determinación de biomarcadores en el carcinoma colorrectal. Consenso Nacional de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Oncología Médica

Adenovirus E1A and Ewing tumors

scientific article published on 01 January 2000

Advances in endometrial cancer protein biomarkers for use in the clinic.

scientific article published on 29 November 2017

Analysis of intra-tumor heterogeneity in Neurofibromatosis Type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.

scientific article

Apocrine carcinoma of the anogenital region. A case report including immunohistochemical and molecular study, discussion of differential diagnosis and a review of the literature

scientific article published on 01 March 2007

Apoptosis in epithelial ovarian tumours Prognostic significance of clinical and histopathologic factors and its association with the immunohistochemical expression of apoptotic regulatory proteins (p53, bcl-2 and bax)

scientific article published on 28 July 2006

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

scientific article published on 06 April 2010

Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

scientific article published on 14 September 2011

Association of congenital hypothalamic hamartoma and hairy polyp.

scientific article published in May 2009

Association of sarcoidosis, low-grade B-lymphoma and epidermoid carcinoma.

scientific article published on September 1997

Association of ventricular noncompaction and histiocytoid cardiomyopathy: case report and review of the literature

scientific article published on 03 July 2012

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 01 September 2018

Autitumoral effect of E1B defective adenoviruses in human malignant cells ⬇️

scientific article published on February 1, 1998

Axillary staging based on molecular analysis: Results of the B-CLOSER-II study

scientific article published on 03 September 2020

Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC

scientific article

Beyond molecular tumor heterogeneity: protein synthesis takes control

scientific article published on 21 February 2018

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy

scientific article published on 13 March 2019

Brush border myosin Ia has tumor suppressor activity in the intestine.

scientific article published on 18 January 2012

Brush border myosin Ia inactivation in gastric but not endometrial tumors.

scientific article

Cajal's Degeneration and Regeneration of the Nervous System

reprint of an English translation of a book by Cajal

Cancer as an ecomolecular disease and a neoplastic consortium

scientific article

Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.

scientific article published on May 2006

Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.

scientific article published on 9 May 2009

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

scientific article

Chondrosarcoma of the Temporal Bone and Otosclerosis ⬇️

scientific article published on January 1, 1998

Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B

scientific article published on 01 February 1999

Clinical and molecular characterization of refractory BRAF mutant metastatic colorectal carcinoma (mCRC): Vall d’Hebron Institute of Oncology phase I program cohort

Clinical implications of intratumor heterogeneity: challenges and opportunities

scientific article published on 22 January 2020

Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.

scientific article

Cogan's syndrome: an oculo-audiovestibular disease.

scientific article published in May 1999

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation

scientific article

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis

scientific article published on 5 February 2018

Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma.

scientific article published in September 2011

Corrigendum: Pío del Río-Hortega: A Visionary in the Pathology of Central Nervous System Tumors

scientific article published on 3 April 2017

Counteracting effects of E1a transformation on cAMP growth inhibition.

scientific article published on July 1993

Crystals in an Oligodendroglioma: An Optical, Histochemical, and Ultrastructural Study ⬇️

scientific article published on March 1, 1990

Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome.

scientific article published on 12 March 2010

Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer

scientific article

Detection of Thyroid Papillary Carcinoma Lymph Node Metastases Using One Step Nucleic Acid Amplification (OSNA): Preliminary Results

scientific article published on 23 December 2014

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas

scientific article published on 01 March 2012

Disruption of the ribosomal P complex leads to stress-induced autophagy

scientific article

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

scientific article published on 10 March 2008

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

scientific article published on 19 May 2011

E1a is an exogenous in vivo tumour suppressor.

scientific article published on 14 April 2017

Early changes in the Schwann cells in experimental allergic neuritis

scientific article published on 01 August 1977

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

scientific article published on 11 July 2013

Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis.

scientific article published on 19 May 2006

Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines

scientific article

Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia.

scientific article published in August 1997

ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines ⬇️

scientific article published on April 3, 2012

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity

scientific article published on 20 November 2017

Evaluation of the intraoperative human papillomavirus test as a marker of early cure at 12 months after electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesion: a prospective cohort study

scientific article published on 25 September 2019

Expression of Wilms' tumor gene (WT1) is associated with survival in malignant pleural mesothelioma.

scientific article published on 10 December 2013

Expression of p21cip1, p27kip1, and p16INk4a cyclin-dependent kinase inhibitors in papillary thyroid carcinoma: correlation with clinicopathological factors.

scientific article published on January 2008

Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

scientific article published on April 2007

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.

scientific article published on 2 October 2015

Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors

scientific article published on 30 October 2010

Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer

scientific article published on 22 August 2018

Fe de errores a «Recomendaciones para la determinación de mutaciones de K-RAS en cáncer de colon»

Fibro-osseous lesions of the external auditory canal

scientific article published on 01 March 1999

Fine needle aspiration cytology of massive bilateral ovarian metastasis of fibrolamellar hepatocellular carcinoma

scientific article published on 01 July 2007

Fluorescence in situ hybridization and immunohistochemistry as diagnostic methods for ALK positive non-small cell lung cancer patients

scientific article

Gene expression-based classifications of fibroadenomas and phyllodes tumours of the breast

scientific article published on 31 January 2015

Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

scientific article

Giant meningioma in a 5-month-old infant ⬇️

scientific article published on 01 April 1988

Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).

scientific article

HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome.

scientific article published on 3 January 2014

Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progres

scientific article published on 23 January 2013

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo

scientific article published on 12 December 2017

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

scientific article published on 26 August 2020

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis ⬇️

scientific article published on August 3, 2012

Identification of somatic gene mutations in penile squamous cell carcinoma.

scientific article published on 27 July 2015

Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms

scientific article

Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva

scientific article published on July 2004

Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer.

scientific article

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

scientific article

Inhibitory neurons in the human epileptogenic temporal neocortex. An immunocytochemical study.

scientific article

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

article

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics

scientific article published on 14 May 2019

Internal translation of the connexin 43 transcript

scientific article

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways

scientific article published on 02 April 2019

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells

scientific article published on 15 October 2015

Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer.

scientific article published on 07 February 2017

Involvement of potassium channels in the progression of cancer to a more malignant phenotype

scientific article

JC virus and human colon carcinoma: an intriguing and inconclusive association.

scientific article published in January 2003

Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas

scientific article published on 01 January 2005

Lafora's disease. An ultrastructural and histochemical study.

scientific article published in January 1974

Lipoma of the uterine corpus: exceptional eventuality combined with an ovarian thecoma.

scientific article published on 26 May 2009

Loss of heterozygosity in the region including the BRCA1 gene on 17q in colon cancer

scientific article published on 01 July 1998

Loss of inhibitory synapses on the soma and axon initial segment of pyramidal cells in human epileptic peritumoural neocortex: implications for epilepsy.

scientific article published in January 1997

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

scientific article published on 06 March 2017

Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function

scientific article published on 29 May 2008

Lymphocytic hypophysitis causing hypopituitarism and diabetes insipidus, and associated with autoimmune thyroiditis, in a non-pregnant woman.

scientific article published on March 1994

MAP17 enhances the malignant behavior of tumor cells through ROS increase

scientific article

MAP17 overexpression is a common characteristic of carcinomas

scientific article

Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma: different clinical and molecular implications

scientific article published on 01 September 1998

Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.

scientific article

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

scientific article

Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid.

scientific article

Molecular determinants of invasion in endometrial cancer.

scientific article published on May 2007

Molecular prescreening to select patient population in early clinical trials

scientific article published on 03 April 2012

Mycophenolate mofetil for lupus nephritis refractory to cyclophosphamide

scientific article published in June 2003

Myo5b knockout mice as a model of microvillus inclusion disease.

scientific article published on 23 July 2015

Novel molecular profiles of endometrial cancer-new light through old windows.

scientific article published on 15 September 2007

Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study

scientific article published on 01 August 2003

Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor

scientific article published on 13 April 2022

Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis.

scientific article published in August 2017

PPP1CA contributes to the senescence program induced by oncogenic Ras.

scientific article published on 19 January 2008

PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy.

scientific article published in May 2008

PTOV1 is overexpressed in human high-grade malignant tumors

Pathological findings in the complete trisomy 9 syndrome: three case reports and review of the literature.

scientific article published on January 2008

Pedro Ramón y Cajal: The Legacy of a Neurohistologist, a Medical Doctor, and a Pathologist

scientific article published on 16 April 2019

Perspectives in gene therapy

scientific article published on 01 January 1998

Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma

scientific article published on 01 September 2006

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

scientific article published on 24 April 2018

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

scientific article published on 01 October 2006

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches

scientific article published on 29 April 2015

Platelet-activating factor mediates glycerol-induced acute renal failure in rats

scientific article published on 01 December 1990

Polymorphisms in MDM2 and TP53 Genes and Risk of Developing Therapy-Related Myeloid Neoplasms

scientific article published in Scientific Reports

Post-transcriptional regulation of connexins

scientific article published on June 2015

Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay

scientific article published on 7 July 2015

Primary thymic epithelial neoplasms in children

scientific article published on 01 May 1991

Procedures in current practice on the writing of scientific papers. 1937.

scientific article published in February 2007

Prognostic Significance of Vascular Endothelial Growth Factor and Cyclooxygenase-2 in Patients with Rectal Cancer Treated with Preoperative Radiotherapy

scientific article published on 01 January 2006

Publisher Correction: ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

scientific article published on 15 September 2020

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

scientific article published on 19 October 2015

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

scientific article

RPLP1, a crucial ribosomal protein for embryonic development of the nervous system

scientific journal article

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence.

scientific article published on 14 January 2011

Recombinant alpha 2-interferon treatment in children with chronic hepatitis B

scientific article published on 01 January 1988

Recurrent pancreatitis after cholecystectomy ⬇️

scientific article published on October 1, 2003

Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1.

scientific article published on 4 March 2013

Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

scientific article

Role of total tumour load of sentinel lymph node on survival in early breast cancer patients.

scientific article

Rplp1 bypasses replicative senescence and contributes to transformation.

scientific article

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

scientific article published on 19 August 2008

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 11 June 2018

Salvage surgery after definitive chemo-radiotherapy for patients with Non-Small Cell Lung Cancer

scientific article published on 13 May 2019

Selective changes in the microorganization of the human epileptogenic neocortex revealed by parvalbumin immunoreactivity.

scientific article published in January 1993

Selective sentinel lymph node biopsy in papillary thyroid carcinoma in patients with no preoperative evidence of lymph node metastasis

scientific article published on 29 June 2017

Sinonasal undifferentiated carcinoma invading the orbit

scientific article published on 01 October 1994

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

scientific article

Subtractive proteomic approach to the endometrial carcinoma invasion front.

scientific article published in October 2009

Surgically induced weight loss by gastric bypass improves non alcoholic fatty liver disease in morbid obese patients

scientific article published on December 2012

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

scientific article published on January 2012

The EMT signaling pathways in endometrial carcinoma.

scientific article published on 22 August 2012

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

scientific article

The distribution of somatostatin-immunoreactive neurons in the visual cortex of adult rabbits and during postnatal development.

scientific article published in December 1985

The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.

scientific article published on 8 July 2011

The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets.

scientific article

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

scientific article

The role of clonal communication and heterogeneity in breast cancer

scientific article published on 05 July 2019

The umbilical cord, preeclampsia and the VEGF family

scientific article published on 28 November 2018

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.

scientific article published on 10 October 2013

Transitional multiple sclerosis (Schilder's disease): a case report

scientific article published on 01 December 2000

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils

scientific article published on 20 February 2018

Translational research in glioblastoma multiforme: molecular criteria for patient selection.

scientific article published on April 2008

Triggering MSR1 promotes JNK‐mediated inflammation in IL‐4‐activated macrophages

scientific article

Updated guidelines for biomarker testing in colorectal carcinoma: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology

scientific article

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

scientific article published on 24 August 2010

c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.

scientific article

mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior.

scientific article published on 11 June 2013

miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.

scientific article

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

scientific article published on 26 October 2017

p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.

scientific article published on 07 February 2011

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.

scientific article published on 20 July 2016

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

scientific article published on June 2012

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