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List of works by Mercedes Gonzalez

1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part II.

scientific article published on May 2004

1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part III.

scientific article published in May 2004

1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.

scientific article

1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships.

scientific article published on June 1999

1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: synthesis and biological evaluation. Part IV ⬇️

scientific article published on October 1, 2001

2-Acetylpyridine- and 2-benzoylpyridine-derived thiosemicarbazones and their antimony(III) complexes exhibit high anti-trypanosomal activity

scholarly article by Gabrieli L. Parrilha et al published January 2012 in Polyhedron

2-Benzyl-2-methyl-2H-benzimidazole 1,3-dioxide derivatives: Spectroscopic and theoretical study

scientific article published on 18 August 2006

2D- and 3D-Quantitative Structure-Activity Relationship Studies for a Series of Phenazine N,N’-Dioxide as Antitumour Agents

scientific article published on 24 October 2011

2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents

scientific article

3-TrifluoromethylquinoxalineN,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruziAgents and Mechanism of Action Studies

scientific article published on 04 May 2011

4-Nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity

scientific article published on 10 July 2007

5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: preliminary in vivo studies.

scientific article published on 14 April 2009

5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.

scientific article published on 15 September 2009

6-Methylnitroarachidonate: a novel esterified nitroalkene that potently inhibits platelet aggregation and exerts cGMP-mediated vascular relaxation

scientific article

A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites

A new series of heteroleptic oxidovanadium(IV) compounds with phenanthroline-derived co-ligands: selective Trypanosoma cruzi growth inhibitors

scientific article published in September 2013

A serendipitous one-step conversion of 3H-1,2-dithiole-3-thione to (E)-3-[1-(alkylthio)alkylidene]-3H-1,2-dithiole: an experimental and theoretical study

scientific article published on 14 January 2014

Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd(II) and Pt(II) complexes of thiosemicarbazones derived from 1-indanones

Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain

Anaerobic metabolism of the agro-pesticide nitroxinil by bovine ruminal fluid

scientific article published in January 2014

Analgesic and Anti-Inflammatory Properties of Arylnitroalkenes

scientific article published on 22 October 2015

Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides

scientific article published on 25 June 2010

Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds

scientific article

Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies

scientific article published on 18 September 2009

Antiparasitic prodrug nifurtimox: revisiting its activation mechanism

scientific article published on August 2011

Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells.

scientific article

Artificial Neural Networks Based on CODES Descriptors in Pharmacology: Identification of Novel Trypanocidal Drugs against Chagas Disease ⬇️

scientific article published on March 1, 2013

Arylethenylbenzofuroxan Derivatives as Drugs for Chagas Disease: Multigram Batch Synthesis using a Wittig−Boden Process‡

Arylnitroalkenes as scavengers of macrophage-generated oxidants.

scientific article

Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds.

scientific article published on 22 August 2005

Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Structure-activity relationships. Part II.

scientific article

Bioactive-guided identification of labdane diterpenoids from aerial parts of Aristeguietia glutinosa as anti-Trypanosoma cruzi agents

scientific article published on September 1, 2012

Biotransformation of Phenazine 5,10-Dioxides under Hypoxic Conditions as an Example of Activation of Anticancer Prodrug: An Interdisciplinary Experiment for Biochemistry or Organic Chemistry

article

Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase

scientific article published on 17 February 2012

Chemo-selective hydrolysis of the iminic moiety in salicylaldehyde semicarbazone promoted by ruthenium

Chemotherapy of Chagas' disease: status and new developments

scientific article

Comparative spectroscopic and electrochemical study of nitroindazoles: 3-alcoxy, 3-hydroxy and 3-oxo derivatives

scientific article published on 6 August 2007

Convenient Route to Primary (Z)-Allyl Amines and Homologs

Coordination of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides to antimony(III) as a strategy for anti-Trypanosoma cruzi activity improvement

scholarly article by Javier Varela et al published 30 December 2011 in Medicinal Chemistry Research

Coordination of nitro-thiosemicarbazones to ruthenium(II) as a strategy for anti-trypanosomal activity improvement

scientific article published on 11 March 2010

Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs.

scientific article

Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction.

scientific article published on 10 July 2009

Cytotoxicity of furoxans: quantitative structure-activity relationships study

scientific article published on May 2004

Design and evaluation of "3 + 1" mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology.

scientific article published on 19 June 2006

Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives

scientific article published on 21 August 2012

Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design.

scientific article published in May 2004

Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives

scientific article

Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

scientific article published in October 2005

Development of a HPLC method for the determination of antichagasic phenylethenylbenzofuroxans and its major synthetic secondary products in the chemical production processes

scientific article

Development of hypoxia selective cytotoxins for cancer treatment: an update

scientific article published on May 2006

Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1,3-dioxide core scaffolds

article

Development, validation and application of a GC-MS method for the simultaneous detection and quantification of neutral lipid species in Trypanosoma cruzi

scientific article

Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides.

scientific article published on 29 July 2008

Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives.

scientific article

ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity

scientific article

ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by electrochemical and Trypanosoma cruzi reduction

scientific article published in September 2003

Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. cruzi activity

article published in 2011

Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones.

scientific article published on 29 August 2009

Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs.

scientific article published on 13 December 2004

Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential antiprotozoal drugs

article

Evaluating 5-nitrofurans as trypanocidal agents.

scientific article

Evaluation of different PAMAM dendrimers as molecular vehicle of 1,2,4-triazine N-oxide derivative with potential antitumor activity

Evaluation of yeasts obtained from Antarctic soil samples as biocontrol agents for the management of postharvest diseases of apple (Malus × domestica).

scientific article published on 13 December 2012

Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine -dioxide derivative with antitumor activity

Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.

scientific article published on 29 July 2008

Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

scientific article published on July 2011

Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action

scientific article published on 21 August 2007

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

scientific article published on 22 June 2009

Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates

scientific article published on 7 November 2012

Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers.

scientific article published on 20 May 2010

Identification of novel benzimidazole derivatives as anti-Trypanosoma cruzi agents: solid-phase synthesis, structure-activity relationships and molecular docking studies

scientific article published on October 2013

Imidazole and benzimidazole derivatives as chemotherapeutic agents

scientific article

Imidazolidines as new anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships

scientific article

Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium

scientific article published on 18 May 2006

In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones.

scientific article published in September 2004

In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles

scientific article published on 28 June 2008

In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives

scientific article published on 26 October 2007

In vivo anti-Trypanosoma cruzi activity of hydro-ethanolic extract and isolated active principles from Aristeguietia glutinosa and mechanism of action studies.

scientific article published on 23 June 2014

In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons

scientific article published on 2 March 2016

In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease

scientific article published on 28 December 2007

Indazole N-oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies

scientific article published on 17 February 2006

Inhibition of LDL oxidation and inflammasome assembly by nitroaliphatic derivatives. Potential use as anti-inflammatory and anti-atherogenic agents

Inhibition of LDL oxidation and inflammasome assembly by nitroaliphatic derivatives. Potential use as anti-inflammatory and anti-atherogenic agents

scholarly article by Nicolás Cataldo et al published November 2018 in European Journal of Medicinal Chemistry

Initial studies on mechanism of action and cell death of active N-oxide-containing heterocycles in Trypanosoma cruzi epimastigotes in vitro

scientific article published on 27 January 2014

Insight into the bioreductive mode of action of antitrypanosomal 5-nitrofuryl containing thiosemicarbazones.

scientific article published in January 2008

Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity.

scientific article published on 29 October 2009

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

scientific article published in March 2018

Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.

scientific article

Mercury and trace element fractionation in Almaden soils by application of different sequential extraction procedures

scientific article published on 05 April 2005

Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

scientific article published on 21 February 2010

Modeling anti-Trypanosoma cruzi activity of N-oxide containing heterocycles

scientific article published on 29 December 2007

Molecular docking and molecular dynamics simulation studies of Trypanosoma cruzi triosephosphate isomerase inhibitors. Insights into the inhibition mechanism and selectivity

scientific article published on 21 February 2015

Mutagenicity of N-oxide containing heterocycles and related compounds: experimental and theoretical studies

scientific article

Naftifine-analogues as anti-Trypanosoma cruzi agents

scientific article

New Synthetic Approach for the Preparation of ImidazoleN 3-Oxide

New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.

scientific article published on 13 February 2013

New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

scientific article published in August 2007

New hits as phase II enzymes inducers from a focused library with heteroatom-heteroatom and Michael-acceptor motives

scientific article

New oxidovanadium(IV) N -acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents

scientific article published on 29 December 2012

New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies

scientific article published on 23 February 2006

New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies

scientific article published on 20 October 2009

New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: quantitative structure-activity relationship studies

scientific article

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships

scientific article published on 15 January 2009

New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle

scientific article published on 20 May 2008

Nitrofurylsemicarbazone Rhenium and Ruthenium Complexes as Anti-trypanosomal Agents

scientific article published on 07 July 2006

Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies

article published in 2005

Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins

scientific article published in May 2005

Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties

scientific article

Novel antiprotozoal products: imidazole and benzimidazole N-oxide derivatives and related compounds.

scientific article published in May 2004

Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets

scholarly article by Lucía Otero et al published 1 June 2006 in Journal of Medicinal Chemistry

Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective ⬇️

scientific article published on March 24, 2011

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents.

scientific article published on 30 May 2013

Novel vanadyl complexes with quinoxaline N(1),N(4)-dioxide derivatives as potent in vitro insulin-mimetic compounds

scientific article published on 4 January 2006

Optimization of Antitrypanosomatid Agents: Identification of Nonmutagenic Drug Candidates with in Vivo Activity

scientific article published on 02 May 2014

Oxidovanadium(IV) and dioxidovanadium(V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents

scientific article

Pd(thiosaccharinato)2·H2O, the first thiosaccharinato complex of a platinum-group metal

Pharmacological properties of indazole derivatives: recent developments

scientific article

Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins.

scientific article

Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies.

scientific article published on September 2006

Phenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activity

Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents

scientific article published on 23 December 2007

Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity.

scientific article published on 24 December 2008

Polypharmacology in the treatment of Chagas disease

scientific article published on 9 April 2018

Potent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: electrochemical, spectroscopic and biological studies

scientific article published on 13 February 2011

Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase.

scientific article published on 6 March 2008

Preparation and biological evaluation of (99m)Tc-labelled phenazine dioxides as potential tracers for hypoxia imaging

scientific article published in January 2015

Preparation and characterization of technetium and rhenium tricarbonyl complexes bearing the 4-nitrobenzyl moiety as potential bioreductive diagnostic radiopharmaceuticals. In vitro and in vivo studies.

scientific article

Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi

scientific article

Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships

scientific article

Quinoxaline derivatives: a patent review (2006--present).

scientific article published on 13 September 2012

Refinement of the mouse model of congenital toxoplasmosis

article

Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives

scientific article published on 30 September 2005

Risedronate metal complexes potentially active against Chagas disease.

scientific article

Ruthenium (II) nitrofurylsemicarbazone complexes: new DNA binding agents

scientific article published on 01 April 2004

Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies

scientific article

Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships

scientific article published on 12 January 2007

Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

scientific article published on 13 June 2007

Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives

scientific article published on 25 April 2006

Solubilization and Release Properties of Dendrimers. Evaluation as Prospective Drug Delivery Systems

Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins.

scientific article published on 16 September 2010

Structural relationships in the solid state of the anti-chagas agent (E)-phenylethenylbenzofuroxan

scientific article published on 10 November 2009

Structure of indazole N1-oxide derivatives studied by X-ray, theoretical methods, 1H, 13C, 15N NMR and EI/MS

Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: electrochemical behaviour and ESR spectroscopic studies.

scientific article published on 23 July 2008

Study of Trypanosoma cruzi epimastigote cell death by NMR-visible mobile lipid analysis

scientific article published on 05 January 2012

Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.

scientific article

Synthesis and Herbicidal Activity ofN-Oxide Derivatives

scientific article published on 01 July 2000

Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents

scientific article published on 24 June 2014

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity

scientific article

Synthesis and biological properties of new 5-nitroindazole derivatives

scientific article

Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease

scholarly article by Lucı́a Otero et al published February 2003 in Inorganica Chimica Acta

Synthesis and characterization of thiol containing furoxan derivatives as coligands for the preparation of potential bioreductive radiopharmaceuticals

scientific article published in February 2006

Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

scientific article published on 14 January 2010

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

scientific article

Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase

scientific article

Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships

scientific article published on 14 March 2007

Targets for Anti-T. cruzi Drugs in the Post-Genomic Era

Tautomerism and Reactivity in HeterocyclicN-Oxides. A Spectroscopic and Theoretical Study of BenzimidazoleN-Oxide Derivatives (N-Hydroxybenzimidazoles)

Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

scientific article published on 24 September 2011

Toxoplasma gondii: Partial cross-protection among several strains of the parasite against congenital transmission in a rat model

article

Toxoplasma gondii: Protection against colonization of the brain and muscles in a rat model

article

Toxoplasma gondii: differential protection rates by two strains against cyst formation in a rat model.

scientific article published on 18 May 2006

Trypanosoma cruzi chemical proteomics using immobilized benznidazole.

scientific article

Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)].

scientific article

Vibrational spectra of palladium 5-nitrofuryl thiosemicarbazone complexes: experimental and theoretical study

article

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