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List of works by Timothy N C Wells

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

scientific article

A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.

scientific article published on September 1997

A fluorescent interleukin-8 receptor probe produced by targetted labelling at the amino terminus.

scientific article published on January 1995

A framework for assessing the risk of resistance for anti-malarials in development

scientific article

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

scientific article published on 27 September 2012

A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock

scientific journal article

A structural and dynamic model for the interaction of interleukin-8 and glycosaminoglycans: support from isothermal fluorescence titrations

scientific article published on March 2004

ATP-citrate lyase from rat liver. Characterisation of the citryl-enzyme complexes.

scientific article published in July 1991

ATP-citrate-lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-.beta.-lactam containing analogs of citric acid as potential tight-binding inhibitors

scientific article published on 01 December 1992

An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.

scientific article published on 28 July 2008

An interleukin 5 mutant distinguishes between two functional responses in human eosinophils.

scientific article published on July 1997

Anticancer properties of distinct antimalarial drug classes

scientific article (publication date: 2013)

Antimalarial drug discovery - the path towards eradication.

scientific article published on 17 July 2013

Arginine 304 Is an Active Site Residue in Phosphomannose Isomerase from Candida albicans

scientific article published on 01 May 1994

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

scientific article published on 31 May 2017

Binding of Interleukin-8 to Heparan Sulfate and Chondroitin Sulfate in Lung Tissue

article

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

scientific article published on July 1990

Characterisation of the RANTES/MIP-1 alpha receptor (CC CKR-1) stably transfected in HEK 293 cells and the recombinant ligands.

scientific article published on November 1995

Chemokine and chemokine receptor mRNA expression in human platelets

scientific article

Chemokine blockers--therapeutics in the making?

scientific article

Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis.

scientific article

Chemokine receptors - the new frontier for AIDS research.

scientific article published on August 1996

Chemokine receptors and their antagonists in allergic lung disease.

scientific article

Chemokine receptors and their role in leukocyte activation.

scientific article

Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor.

scientific article

Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells

scientific article

Cloning and characterization of human chemokine receptors.

scientific article

Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets

scientific article

Coreceptor ligand inhibition of fetal brain cell infection by HIV type 1.

scientific article published in July 1999

Crystallization and Preliminary X-ray Analysis of Candida albicans Phosphomannose Isomerase

article

Crystallization and Preliminary X-ray Diffraction Studies of Human RANTES

Crystallization and Preliminary X-ray Diffraction Studies of Recombinant Human Interleukin-5

article

Differential activation of CC chemokine receptors by AOP-RANTES

scientific article

Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro

scientific article published on 30 March 2006

Discovering and developing new medicines for malaria control and elimination

scientific article published in August 2013

Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice

scientific article published on 01 June 1997

Eotaxin protein and gene expression in guinea-pig lungs: constitutive expression and upregulation after allergen challenge

article

Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs.

scientific article published on November 1994

Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

scientific article published on February 1996

Ferroquine: welcome to the next generation of antimalarials

scientific article published on 2 September 2015

Free energy of hydrolysis of tyrosyl adenylate and its binding to wild-type and engineered mutant tyrosyl-tRNA synthetases

scientific article published on 01 October 1986

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy

scientific article published on 21 July 2008

Glycosaminoglycan analogs as a novel anti-inflammatory strategy

scientific article

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

scholarly article

Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines ⬇️

article by Arlene J. Hoogewerf et al published November 1997 in Biochemistry

HIV-1 Tat protein mimicry of chemokines

scientific article

Identification of a glycosaminoglycan binding surface on human interleukin-8.

scientific article

Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.

scientific article

Imaging of proteins by scanning tunnelling microscopy

scientific article published on 01 July 1992

Influence of surface and protein modification on immunoglobulin G adsorption observed by scanning force microscopy.

scientific article published on September 1994

Inhibition of phosphomannose isomerase by mercury ions.

scientific article

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

scientific article published on February 1998

Isolation of a Lipid-Soluble Histamine Release Factor from Human Platelets

scientific article published on 01 May 1994

Kinetic and thermodynamic properties of wild-type and engineered mutants of tyrosyl-tRNA synthetase analyzed by pyrophosphate-exchange kinetics

scientific article published on 01 May 1991

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs

scientific article published on February 2010

Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo

scientific article

Linear free energy relationships in enzyme binding interactions studied by protein engineering

scientific article published on 01 February 1991

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

scientific article

Malaria

scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers

Malaria medicines: a glass half full?

scientific article published on 22 May 2015

Managing intellectual property to develop medicines for the world's poorest

scientific article published on 24 February 2017

Microbiology. Is the tide turning for new malaria medicines?

scientific article published in September 2010

Molecular Cloning and Functional Expression of a Novel CC Chemokine Receptor cDNA from a Human Basophilic Cell Line ⬇️

scientific article published on August 18, 1995

Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus.

scientific article

Multi-faceted strategies to combat disease by interference with the chemokine system

scientific article

Mutation of Leu25and Val27Introduces CC Chemokine Activity into Interleukin-8

scientific article published in Journal of Biological Chemistry

Natural products as starting points for future anti-malarial therapies: going back to our roots? ⬇️

scientific article published on March 15, 2011

New developments in anti-malarial target candidate and product profiles

scientific article

New medicines to improve control and contribute to the eradication of malaria

scientific article published on 16 October 2009

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open source drug discovery - a limited tutorial

scientific article (publication date: 2014)

Ophioluxin, a Convulxin-like C-type Lectin from Ophiophagus hannah (King Cobra) Is a Powerful Platelet Activator via Glycoprotein VI

scientific article published in Journal of Biological Chemistry

Orally active antischistosomal early leads identified from the open access malaria box

scientific article (publication date: 2014)

Peptides from the Amino Terminus of Rantes Cause Chemotaxis of Human T-Lymphocytes

scientific article published on 01 June 1995

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

scientific article

Phosphomannose isomerase from Saccharomyces cerevisiae contains two inhibitory metal ion binding sites.

scientific article published in February 1993

Plagiarism of the host immune system: lessons about chemokine immunology from viruses.

scientific article published on December 1997

Plasma Concentrations and Role of Macrophage Inflammatory Protein–1α during ChronicSchistosoma mansoniInfection in Humans

scientific article published on 11 November 2002

Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor

scientific article

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

scientific article published on April 1997

Preliminary X-ray diffraction studies of recombinant 19 kDa human fibroblast collagenase

article

Preparation of (±)-(erythro)-and (±)-(threo)-2-vinyl citric acids as potential mechanism-based inhibitors of ATP-citrate lyase

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine

scientific article

Protection of an unstable reaction intermediate examined with linear free energy relationships in tyrosyl-tRNA synthetase

scientific article published on 01 November 1989

Purification and characterization of fungal and mammalian phosphomannose isomerases

scientific article published on 01 October 1994

Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase

scientific journal article

Purification, characterisation and crystallisation of selenomethionyl recombinant human interleukin-5 from Escherichia coli.

scientific article

RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis

scientific article

Redox control of catalysis in ATP-citrate lyase from rat liver

scientific article published on 01 February 1992

Repositioning: the fast track to new anti-malarial medicines?

scientific article

Role of CCL5 (RANTES) in viral lung disease.

scientific article

Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B

scientific article

Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

scientific article

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.

scientific article published on 5 July 2017

Selenomethionine Labelling of Phosphomannose Isomerase Changes its Kinetic Properties ⬇️

scientific article published on May 15, 1995

Solid-phase binding assay to study interaction of chemokines with glycosaminoglycans

scientific article published on 01 January 1997

Spatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs

scientific article published in Journal of Biological Chemistry

Strategies for chemokine antagonists as therapeutics

scientific article

Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

scientific article

Structure and bioactivity of recombinant human CTAP-III and NAP-2.

scientific article

Structure of immunoglobulin G by scanning tunnelling microscopy.

scientific article

Susceptibility Testing of Medically Important Parasites

scientific article published on July 2017

Synthesis and evaluation of (+) and (-)-2,2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase

scientific article published on 01 December 1991

Synthesis and evaluation of fluorescent chemokines labeled at the amino terminal

article

Synthesis of Novel Thiol-Containing Citric Acid Analogs. Kinetic Evaluation of These and Other Potential Active-Site-Directed and Mechanism-Based Inhibitors of ATP Citrate Lyase

scientific article published on 01 February 1995

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

scientific article published on 03 February 2010

The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity

scientific article (publication date: 6 April 2001)

The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3

scientific article published on 01 November 1997

The Complete Primary Structure of Glycosylated Porcine Platelet Factor 4

scientific article published on 01 March 1995

The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness ⬇️

scientific article published on July 6, 1998

The Molecular Basis of the Chemokine/Chemokine Receptor Interaction—Scope for Design of Chemokine Antagonists

scientific article published on 01 August 1996

The Swiss-3DImage collection and PDB-Browser on the World-Wide Web

article

The Three-Dimensional Structure of Human Interleukin-5 at 2.4-Angstroms Resolution: Implication for the Structures of Other Cytokines

scientific article published on 01 May 1994

The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.

scientific article

The global pipeline of new medicines for the control and elimination of malaria

scientific article

The global portfolio of new antimalarial medicines under development.

scientific article published on 29 April 2009

The open access malaria box: a drug discovery catalyst for neglected diseases

scientific article (publication date: 2013)

The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors

scientific article (publication date: 8 October 1999)

The state of the art in anti-malarial drug discovery and development

scientific article published on January 2011

The three-dimensional solution structure of RANTES

scientific article

The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation

scientific article

Ticks produce highly selective chemokine binding proteins with antiinflammatory activity

scientific article published on 4 August 2008

Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?

scientific article

Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis.

scientific article

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