List of works - Marilyn Parsons

35 years of molecular and biochemical parasitology.

scientific article published in July 2014

A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA.

scientific article published in May 1993

A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization.

scientific article published on March 1999

A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody

scientific article published in Science

A membrane protease is targeted to the relict plastid of toxoplasma via an internal signal sequence

scientific article published on 6 September 2007

A novel protein kinase is essential in bloodstream Trypanosoma brucei

scientific article published on 23 March 2016

A novel protein kinase localized to lipid droplets is required for droplet biogenesis in trypanosomes.

scientific article

Active transport of 2-deoxy-D-glucose in Trypanosoma brucei procyclic forms

scientific article published on 01 September 1990

Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping

scientific article

Antigenic variation in African trypanosomes: DNA rearrangements program immune evasion.

scientific article published on February 1984

Apicoplast targeting of a Toxoplasma gondii transmembrane protein requires a cytosolic tyrosine-based motif

scientific article

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

scientific article

Binding of 125I-Labeled Proteinases to Plasma Proteins in Cystic Fibrosis

scientific article published on September 1, 1979

Biogenesis and function of peroxisomes and glycosomes

scientific article (publication date: June 2001)

Biogenesis of glycosomes of Trypanosoma brucei: an in vitro model of 3-phosphoglycerate kinase import

scientific article

Cell cycle-regulated vesicular trafficking of Toxoplasma APT1, a protein localized to multiple apicoplast membranes

scientific article published on 01 March 2007

Characterization of a Trypanosoma brucei nuclear gene encoding a protein homologous to a subunit of bovine NADH:ubiquinone oxidoreductase (complex I).

scientific article published in March 1993

Characterization of an in vitro assay for import of 3-phosphoglycerate kinase into the glycosomes of Trypanosoma brucei.

scientific article published on September 1990

Characterization of glycosomal RING finger proteins of trypanosomatids

scientific article

Characterization of protein kinase CK2 from Trypanosoma brucei.

scientific article published on 19 October 2006

Cloning and expression of Trypanosoma cruzi ribosomal protein P0 and epitope analysis of anti-P0 autoantibodies in Chagas' disease patients ⬇️

scientific article published on July 1, 1992

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

scholarly article

Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes

scientific article

Current concepts in stage-regulated gene expression in kinetoplastida

scientific article published on 01 August 1990

Cystic fibrosis alpha 2-macroglobulin protease interaction in vitro

scientific article published on 01 January 1980

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity ⬇️

scientific article published on February 27, 2012

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

scientific article published on 16 June 2016

Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.

scientific article published in January 1994

Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei

scientific article published on 01 April 1991

Elevated phosphoglycerate kinase mRNA but not protein in monomorphic Trypanosoma brucei: implications for stage-regulation and post-transcriptional control

scientific article published on 01 March 1989

Enigmatic Presence of Mitochondrial Complex I in Trypanosoma brucei Bloodstream Forms ⬇️

scientific article published on December 9, 2011

Evolving insights into protein trafficking to the multiple compartments of the apicomplexan plastid.

scientific article published on May 2009

Expression of a Trypanosoma brucei brucei variant antigen in Escherichia coli ⬇️

scientific article published on February 1, 1984

Expression of a minichromosomal variant surface glycoprotein gene in Trypanosoma brucei.

scientific article published in February 1985

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

scientific article

Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes

scientific article

Genetic characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies

scientific article published on 01 January 1983

Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei

scientific article published on 21 February 2014

Genomic organization of Trypanosoma brucei variant antigen gene families in sequential parasitemias.

scientific article published on November 1983

Glucose is toxic to glycosome-deficient trypanosomes.

scientific article

Glycosomes: parasites and the divergence of peroxisomal purpose

scientific article

Human immunoglobulin allotypes: previously unrecognized determinants and alleles defined with monoclonal antibodies

scientific article published on June 1983

Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number.

scientific article published on 7 April 2005

Identity crisis? The need for systematic gene IDs.

scientific article

Igh-4d, a new allotype at the mouse IgG1 heavy chain locus

scientific article published on 01 January 1981

Illuminating Parasite Protein Production by Ribosome Profiling

scientific article published on 06 April 2016

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

scientific article

Isolation and characterization of Leishmania mutants defective in glycosomal protein import

scientific article published on 01 March 2000

Leishmania gp63 molecule implicated in cellular adhesion lacks an Arg-Gly-Asp sequence.

scientific article published in March 1990

Molecular characterization of initial variants from the IsTat I serodeme of Trypanosoma brucei

scientific article published on 01 November 1983

Molecular cloning of Trypanosoma brucei CK2 catalytic subunits: the α isoform is nucleolar and phosphorylates the nucleolar protein Nopp44/46 ⬇️

scientific article published on January 1, 2002

Molecular cloning of the glycosomal malate dehydrogenase of Trypanosoma brucei.

scientific article published in October 1998

Pathways involved in environmental sensing in trypanosomatids.

scientific article

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

scientific article

Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei: RNA interference studies of PEX14, hexokinase, and phosphofructokinase.

scientific article published on 6 January 2005

Protein kinases as drug targets in trypanosomes and Leishmania

scientific article

Protein trafficking to the apicoplast: deciphering the apicomplexan solution to secondary endosymbiosis.

scientific article

Purine uptake by azaguanine-resistant Chinese hamster cells

scientific article published on 01 October 1976

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

scientific article

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy

scientific article

Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation

scientific article published in Nature

Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking

scientific article

Structural characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies ⬇️

scientific article published on January 1, 1983

The C-terminal tripeptide of glycosomal phosphoglycerate kinase is both necessary and sufficient for import into the glycosomes of Trypanosoma brucei.

scientific article

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

scientific article

The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit

scientific article

The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46

scientific article

The trypanosome spliced leader small RNA gene family: stage-specific modification of one of several similar dispersed genes.

scientific article published on February 1986

Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense.

scientific article published in February 1995

Toxoplasma calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays

scientific article published on 19 March 2018

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

scientific article

Trypanosoma brucei: Two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form ⬇️

scientific article published on March 17, 2011

Trypanosoma brucei: analysis of codon usage and nucleotide composition of nuclear genes

scientific article published on 01 July 1991

Trypanosoma brucei: identification of an internal region of phosphoglycerate kinase required for targeting to glycosomal microbodies

scientific article published on 01 January 1997

Trypanosoma brucei: molecular cloning and stage-regulated expression of a malate dehydrogenase localized to the mitochondrion.

scientific article published on May 1998

Trypanosome mRNAs share a common 5' spliced leader sequence.

scientific article published on August 1984

Trypsin-binding IgG in cystic fibrosis

scientific article published on August 31, 1978

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii ⬇️

scientific article published on 22 February 2018

Variant antigen genes of Trypanosoma brucei: genomic alteration of a spliced leader orphon and retention of expression-linked copies during differentiation.

scientific article

Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption

scientific article

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei

scientific article

List of works by Marilyn Parsons

35 years of molecular and biochemical parasitology.

A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA.

A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization.

A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody

A membrane protease is targeted to the relict plastid of toxoplasma via an internal signal sequence

A novel protein kinase is essential in bloodstream Trypanosoma brucei

A novel protein kinase localized to lipid droplets is required for droplet biogenesis in trypanosomes.

Active transport of 2-deoxy-D-glucose in Trypanosoma brucei procyclic forms

Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping

Antigenic variation in African trypanosomes: DNA rearrangements program immune evasion.

Apicoplast targeting of a Toxoplasma gondii transmembrane protein requires a cytosolic tyrosine-based motif

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

Binding of 125I-Labeled Proteinases to Plasma Proteins in Cystic Fibrosis

Biogenesis and function of peroxisomes and glycosomes

Biogenesis of glycosomes of Trypanosoma brucei: an in vitro model of 3-phosphoglycerate kinase import

Cell cycle-regulated vesicular trafficking of Toxoplasma APT1, a protein localized to multiple apicoplast membranes

Characterization of a Trypanosoma brucei nuclear gene encoding a protein homologous to a subunit of bovine NADH:ubiquinone oxidoreductase (complex I).

Characterization of an in vitro assay for import of 3-phosphoglycerate kinase into the glycosomes of Trypanosoma brucei.

Characterization of glycosomal RING finger proteins of trypanosomatids

Characterization of protein kinase CK2 from Trypanosoma brucei.

Cloning and expression of Trypanosoma cruzi ribosomal protein P0 and epitope analysis of anti-P0 autoantibodies in Chagas' disease patients ⬇️

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes

Current concepts in stage-regulated gene expression in kinetoplastida

Cystic fibrosis alpha 2-macroglobulin protease interaction in vitro

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity ⬇️

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.

Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei

Elevated phosphoglycerate kinase mRNA but not protein in monomorphic Trypanosoma brucei: implications for stage-regulation and post-transcriptional control

Enigmatic Presence of Mitochondrial Complex I in Trypanosoma brucei Bloodstream Forms ⬇️

Evolving insights into protein trafficking to the multiple compartments of the apicomplexan plastid.

Expression of a Trypanosoma brucei brucei variant antigen in Escherichia coli ⬇️

Expression of a minichromosomal variant surface glycoprotein gene in Trypanosoma brucei.

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes

Genetic characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies

Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei

Genomic organization of Trypanosoma brucei variant antigen gene families in sequential parasitemias.

Glucose is toxic to glycosome-deficient trypanosomes.

Glycosomes: parasites and the divergence of peroxisomal purpose

Human immunoglobulin allotypes: previously unrecognized determinants and alleles defined with monoclonal antibodies

Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number.

Identity crisis? The need for systematic gene IDs.

Igh-4d, a new allotype at the mouse IgG1 heavy chain locus

Illuminating Parasite Protein Production by Ribosome Profiling

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

Isolation and characterization of Leishmania mutants defective in glycosomal protein import

Leishmania gp63 molecule implicated in cellular adhesion lacks an Arg-Gly-Asp sequence.

Molecular characterization of initial variants from the IsTat I serodeme of Trypanosoma brucei

Molecular cloning of Trypanosoma brucei CK2 catalytic subunits: the α isoform is nucleolar and phosphorylates the nucleolar protein Nopp44/46 ⬇️

Molecular cloning of the glycosomal malate dehydrogenase of Trypanosoma brucei.

Pathways involved in environmental sensing in trypanosomatids.

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei: RNA interference studies of PEX14, hexokinase, and phosphofructokinase.

Protein kinases as drug targets in trypanosomes and Leishmania

Protein trafficking to the apicoplast: deciphering the apicomplexan solution to secondary endosymbiosis.

Purine uptake by azaguanine-resistant Chinese hamster cells

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy

Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation

Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking

Structural characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies ⬇️

The C-terminal tripeptide of glycosomal phosphoglycerate kinase is both necessary and sufficient for import into the glycosomes of Trypanosoma brucei.

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit

The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46

The trypanosome spliced leader small RNA gene family: stage-specific modification of one of several similar dispersed genes.

Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense.

Toxoplasma calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Trypanosoma brucei: Two mitogen activated protein kinase kinases are dispensable for growth and virulence of the bloodstream form ⬇️

Trypanosoma brucei: analysis of codon usage and nucleotide composition of nuclear genes

Trypanosoma brucei: identification of an internal region of phosphoglycerate kinase required for targeting to glycosomal microbodies

Trypanosoma brucei: molecular cloning and stage-regulated expression of a malate dehydrogenase localized to the mitochondrion.

Trypanosome mRNAs share a common 5' spliced leader sequence.

Trypsin-binding IgG in cystic fibrosis

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii ⬇️

Variant antigen genes of Trypanosoma brucei: genomic alteration of a spliced leader orphon and retention of expression-linked copies during differentiation.