List of works - David W. Gray

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

scientific article published on 9 November 2015

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A pharmacological profile of the endothelium-derived relaxant factor released by calcitonin gene-related peptide in rat aorta

scientific article published on June 30, 1992

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

scientific article

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

scientific article

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 27 February 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 05 June 2017

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

scientific article published on 05 May 2006

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

scientific article

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 01 November 2018

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

scientific article published on 16 July 2019

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

scientific article published on 9 April 2013

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

scientific article published in Nature

Design and synthesis of an array of selective androgen receptor modulators.

scientific article published on January 2007

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

scientific article

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery

scientific article published on 12 July 2018

Differential effects of lithium on muscarinic cholinoceptor-stimulated CMP-phosphatidate accumulation in cerebellar granule cells, CHO-M3 cells, and SH-SY5Y neuroblastoma cells.

scientific article

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

scientific article published on 18 September 2015

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

scientific article

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.

scientific article

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

scholarly article published in Antimicrobial Agents and Chemotherapy

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

scientific article published on 17 January 2014

Human alpha-calcitonin gene-related peptide stimulates adenylate cyclase and guanylate cyclase and relaxes rat thoracic aorta by releasing nitric oxide

scientific article published on November 1992

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

scientific article published on 20 December 2018

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening

scientific article

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

scientific article published on 23 August 2019

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

scientific article

Identification of UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

scientific article published on 12 March 2019

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

scientific article published in January 2019

Identification of small molecule inhibitors of pre-mRNA splicing

scientific article

Identification of small molecule inhibitors of pre-mRNA splicing

scientific article published on 01 March 2015

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex.

scientific article

Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.

scientific article published in May 1994

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

scientific article

Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta

scientific article published on 01 February 1992

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function

scientific article published on 11 December 2019

Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta ⬇️

scientific article published on November 1, 1992

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

Sodium dependency of constitutive activity at 5-HT1D alpha/1D beta receptors

scientific article published on 01 May 1997

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

scientific article published on 03 July 2019

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

scientific article

Targeting N-myristoylation for therapy of B-cell lymphomas

scientific article published on 22 October 2020

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.

scientific article

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment

scientific article published on 23 September 2019

List of works by David W. Gray

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

A novel multiple-stage antimalarial agent that inhibits protein synthesis

A pharmacological profile of the endothelium-derived relaxant factor released by calcitonin gene-related peptide in rat aorta

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Design and synthesis of an array of selective androgen receptor modulators.

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery

Differential effects of lithium on muscarinic cholinoceptor-stimulated CMP-phosphatidate accumulation in cerebellar granule cells, CHO-M3 cells, and SH-SY5Y neuroblastoma cells.

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.

Human alpha-calcitonin gene-related peptide stimulates adenylate cyclase and guanylate cyclase and relaxes rat thoracic aorta by releasing nitric oxide

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

Identification of UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Identification of small molecule inhibitors of pre-mRNA splicing

Identification of small molecule inhibitors of pre-mRNA splicing

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex.

Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.

Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function

Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta ⬇️

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Sodium dependency of constitutive activity at 5-HT1D alpha/1D beta receptors

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

Targeting N-myristoylation for therapy of B-cell lymphomas

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment