List of works - Fabio Zuccotto

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

scientific article published in November 2003

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A platform for target prediction of phenotypic screening hit molecules

scientific article published on 24 October 2019

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

article published in the Proceedings of the National Academy of Sciences of the United States of America

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article published on 25 May 2016

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

scientific article published in Nature

DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase

scientific article published on October 2000

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

scientific article

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

scientific article

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

scientific article

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

scientific article

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

scientific article

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

scientific article

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

scientific article

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

scientific article published on 26 July 2018

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

scientific article published on 04 October 2021

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

scientific article published in January 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

scientific article published on 09 March 2021

NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases

scientific article

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

scientific article published on 03 September 2018

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

scientific article published on 10 September 2018

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

scholarly article by Victoriano Corpas-Lopez et al published 12 November 2018 in ACS Infectious Diseases

Pharmacophore features distributions in different classes of compounds.

scientific article published in September 2003

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

Prediction of Drug Penetration in Tuberculosis Lesions

scientific article published on 06 July 2016

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

scientific article published on 5 February 2018

Structure-based optimization of potent PDK1 inhibitors

scientific article

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

scientific article published on 30 January 2020

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article published on May 1999

List of works by Fabio Zuccotto

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

A novel multiple-stage antimalarial agent that inhibits protein synthesis

A platform for target prediction of phenotypic screening hit molecules

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

Pharmacophore features distributions in different classes of compounds.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Prediction of Drug Penetration in Tuberculosis Lesions

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Structure-based optimization of potent PDK1 inhibitors

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.