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List of works by Adele M Lehane

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

1H-NMR metabolite profiles of different strains of Plasmodium falciparum

scientific article

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

scientific article published on 16 July 2019

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

scientific article published on 3 March 2017

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article (publication date: 31 March 2015)

A polymorphic drug pump in the malaria parasite

scientific article published in November 2008

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

scientific article published on 29 April 2008

An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article

Bacteriophage-encoded glucosyltransferase GtrII of Shigella flexneri: membrane topology and identification of critical residues

scientific article published on July 2005

Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter

scientific article published on 20 May 2015

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

Biochemical characterization and chemical inhibition of PfATP4-associated Na-ATPase activity in membranes

scientific article published in Journal of Biological Chemistry

Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials

scholarly article by Adelaide S M Dennis et al published June 2018 in Antimicrobial Agents and Chemotherapy

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

scientific article published on 13 October 2008

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.

scientific article

Choline uptake into the malaria parasite is energized by the membrane potential

scientific article

Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite

scientific article

Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption

scientific article published on 19 July 2018

Degrees of chloroquine resistance in Plasmodium - is the redox system involved?

scientific article

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.

scientific article

Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis.

scientific article

Diverse chemotypes disrupt ion homeostasis in the Malaria parasite

scientific article

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

scientific article published on 28 June 2010

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite

scientific article published on 20 June 2007

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

scientific article published on 18 May 2016

Membrane transport in the malaria parasite and its host erythrocyte

scientific article published on January 2014

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

PfCRT and its role in antimalarial drug resistance

scientific article (publication date: November 2012)

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum

scientific article

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

scientific article (publication date: February 2017)

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs

scientific article published on 26 October 2015

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