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List of works by Alexander D Douglas

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys

scientific article

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

scientific article published on 26 April 2019

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

article

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.

scientific article published on 30 January 2017

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

scientific article published on 25 October 2013

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

scientific article

Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines

scientific article published on 18 June 2013

Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial

scientific article

Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection

scientific article published on 09 April 2013

Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

scientific article published on 4 February 2016

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens

scientific article

Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article published in Nature Communications

Evaluation of Point-of-care Activated Partial Thromboplastin Time Testing by Comparison to Laboratory-based Assay for Control of Intravenous Heparin

scientific article published on 26 April 2009

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals

scientific article

External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance

scientific article (publication date: 2014)

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

scientific article published on 4 June 2019

Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines.

scientific article published on 13 July 2016

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

scientific article published on 13 June 2019

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

scientific article published on 2 November 2017

Immunological considerations for SARS-CoV-2 human challenge studies

scientific article published on 21 October 2020

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

scientific article

Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

scientific article

Manufacturing a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine to meet global needs

scientific article published on 15 November 2021

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.

scientific article

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

scientific article

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax

scientific article

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

scientific article

Production, quality control, stability, and potency of cGMP-produced RH5.1 protein vaccine expressed in S2 cells

scientific article published on 17 August 2018

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

scientific article published on 08 December 2020

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

scientific article published on 18 November 2020

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

scientific article published on 20 July 2020

Simian adenovirus vector production for early-phase clinical trials: A simple method applicable to multiple serotypes and using entirely disposable product-contact components

scientific article published on 30 April 2019

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

scientific article published in February 2021

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

scientific article

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

scientific article

Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1.

scientific article

The Difficult Venous Ulcer: Case Series of 177 Ulcers Referred for Vascular Surgical Opinion Following Failure of Conservative Management

scientific article published on 26 April 2009

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article

The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus

scientific article

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

scientific article published on January 2013