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List of works by Dennis E Kyle

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

scientific article published on 5 November 2012

4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities

scientific article

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni

scientific article published on 30 September 2013

A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal

scientific article published on September 2002

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.

scientific article

A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi

scientific article published in December 1993

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A potent antimalarial trichothecene from hyphomycete species

article

Acid catalyzed michael additions to artemisitene

article

Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile

scientific article

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds

scientific article published on May 2010

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model

scientific article published on 16 February 2016

An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing

scientific article published on 01 March 2020

Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis

scientific article published on January 2002

Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines

scientific article

Antimalarial activity of new dihydroartemisinin derivatives. 7. 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy]butyric acids.

scientific article published on April 1997

Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes

scientific article published on July 2003

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

scientific article published on January 2009

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model

scientific article published on 23 July 2007

Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.

scientific article published in May 2000

Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

scientific article published on 27 January 2012

Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

scientific article

Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes

scientific article published on 16 March 2015

Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure

scientific article

Artemisone--a highly active antimalarial drug of the artemisinin class

scientific article published in March 2006

Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.

scientific article

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta

scientific article

Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens

scientific article

Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae).

scientific article

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs

scientific article published on 22 August 2011

Characteristics of Multidrug Resistance in Plasmodium and Leishmania: Detection of P-Glycoprotein-Like Components

scientific article published on July 1, 1991

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery.

scientific article

Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity.

scientific article published on August 2000

Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand

scientific article published on January 1996

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins

scientific article

Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria

scientific article published on December 1, 2001

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

scientific article published on 04 October 2006

Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate

scientific article published in April 2005

Correction to Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines

scientific article published on 12 January 2016

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article published on 25 May 2016

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review

scientific article published on March 2009

Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro

scientific article published on 26 April 2010

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

scientific article published on 7 December 2017

Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum

scientific article

Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria.

scientific article published on 20 April 2007

Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1.

scientific article published in May 2007

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae

scientific article published on 24 September 2020

Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity

scientific article

Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya.

scientific article published on September 2004

EdU Incorporation To Assess Cell Proliferation and Drug Susceptibility in Naegleria fowleri

scientific article published on 17 June 2021

Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei

scientific article

Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine

scientific article

Efficacy comparison of intravenous artelinate and artesunate in Plasmodium berghei-infected Sprague-Dawley rats.

scientific article published in April 2003

Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores

scientific article published on August 2002

Efficacy of quinine-tetracycline for acute uncomplicated falciparum malaria in Thailand.

scientific article published in February 1992

Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro

scientific article published on April 2002

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

scientific article published on November 1987

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity

scientific article published on October 2010

Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii

scientific article

Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum

scientific article published on 08 June 2009

Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target

scientific article published in March 2004

Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.

scientific article published on 21 October 2013

Evidence for the shikimate pathway in apicomplexan parasites.

scientific article published on June 1998

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

scientific article

Failure to detect a Plasmodium vivax-like malaria parasite in globally collected blood samples.

scientific article

Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum

scientific article

Field trials of an asexual blood stage malaria vaccine: studies of the synthetic peptide polymer SPf66 in Thailand and the analytic plan for a phase IIb efficacy study.

scientific article published in January 1995

First evidence of polychaete intermediate hosts for Neospirorchis spp. marine turtle blood flukes (Trematoda: Spirorchiidae)

scholarly article published by Isaure de Buron in 2018

Fitness of artemisinin-resistant Plasmodium falciparum in vitro

scientific article

Flow cytometric immunophenotyping of lymphocyte subsets in samples that contain a high proportion of non-lymphoid cells

scientific article published on 01 December 1994

Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.

scientific article published on December 1992

Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests

scientific article

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity

scientific article

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries

scientific article

In vitro screening of the open source MMV Malaria and Pathogen Boxes to discover novel compounds with activity against Balamuthia mandrillaris

scientific article published on 18 February 2020

Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima.

scientific article published on 20 December 2017

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

scientific article

Lead optimization of antimalarial propafenone analogues.

scientific article published on 29 June 2012

Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum.

scientific article published on 23 October 2013

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Malaria causal prophylactic activity of imidazolidinedione derivatives

scientific article published on 30 October 2007

Malaria: progress, perils, and prospects for eradication

scientific article

Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance.

scientific article published on December 2000

Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes

scientific article published on 5 June 2017

Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes: Correlations of Structural Studies with Antimalarial Activity

scientific article published on 01 March 2000

Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes

scientific article published on October 2014

Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery

scientific article published on 26 December 2014

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

scientific article published in 2021

Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.

scientific article published in October 2009

Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro

scientific article

Novel arylimidamides for treatment of visceral leishmaniasis

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

scientific article published on 01 December 2018

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships

scientific article published on 16 June 2011

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

scientific article

Origin and dissemination of chloroquine-resistant Plasmodium falciparum with mutant pfcrt alleles in the Philippines

scientific article

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

scientific article published in August 2003

Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone

scientific article published on June 1, 1996

Pharmacokinetics of quinine and 3-hydroxyquinine in severe falciparum malaria with acute renal failure.

scientific article

Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.

scientific article

Phase I trial of the SPf66 malaria vaccine in a malaria-experienced population in Southeast Asia

scientific article published in May 1997

Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum

scientific article published on 14 November 2011

Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition

scientific article published on 10 October 2011

Phenotypic screens reveal posaconazole as rapidly cidal combination partner for treatment of Primary Amoebic Meningoencephalitis

scholarly article by Beatrice L Colon et al published 24 October 2018 in Journal of Infectious Diseases

Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates

scientific article

Phytohormones, isoprenoids and role of the apicoplast in recovery from dihydroartemisinin-induced dormancy of Plasmodium falciparum

scientific article published on 8 January 2018

Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes

scientific article

Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum

scientific article published on March 2004

Plasmodium falciparum: the effects of atovaquone resistance on respiration.

scientific article

Plasmodium falciparum:Evaluation of Lactate Dehydrogenase in Monitoring Therapeutic Responses to Standard Antimalarial Drugs in Nigeria

scientific article published on November 1, 1997

Plasmodium vivax: isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates.

scientific article published on 20 March 2006

Protozoan persister-like cells and drug treatment failure

scientific article published on 23 August 2019

Pyronaridine.

scientific article

Qualitative and semiquantitative polymerase chain reaction to predict Plasmodium falciparum treatment failure.

scientific article published in December 1994

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

scientific article

Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria

scientific article published on April 4, 1992

Real-time PCR to quantify Leishmania donovani in hamsters

scientific article

Regulation of Leukocyte Adhesion Molecules CD11b/CD18 and Leukocyte Adhesion Molecule-1 on Phagocytic Cells Activated by Malaria Pigment

scientific article published on October 1, 1997

Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae

scientific article

Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys

article published in 2018

Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys

scientific article published on January 1993

Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria.

scientific article published on January 1993

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

scientific article published on 12 August 2019

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum

scientific article

SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand.

scientific article published in September 1997

Screening mangrove endophytic fungi for antimalarial natural products

scientific article published on 12 December 2013

Seasonal Distribution of Thermotolerant Free-Living Amoebae. II. Lake Issaqueena1

article

Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes.

scientific article

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral

scientific article

Shikimate pathway in apicomplexan parasites

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

scientific article published on 12 February 2016

Stage specific detection and inhibition studies of Plasmodium falciparum telomerase

scientific article published on 01 September 1998

Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi.

scientific article

Structural analysis of chloroquine resistance reversal by imipramine analogs.

scientific article

Structure and antimalarial activity of adducts of 11-azaartemisinin with conjugated terminal acetylenes

scientific article published on 01 October 1999

Syntheses and Antimalarial Activities of 10-Substituted Deoxoartemisinins

scientific article published on 01 November 2000

Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines

scientific article published in May 2002

Synthesis and Activity of a New Series of Antileishmanial Agents

scientific article

Synthesis and antimalarial activities of base-catalyzed adducts of 11-azaartemisinin

scientific article published on 01 May 2000

Synthesis and antimalarial activity of new isotebuquine analogues

scientific article published on February 2007

Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents

scientific article published on August 2002

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones

scientific article

Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine.

scientific article published on 14 September 2017

The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum.

scientific article published on 28 December 2010

The shikimate pathway and its branches in apicomplexan parasites

scientific article

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

scientific article

Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum

scientific article published on July 1988

Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives

scientific article

Vertical distribution of potentially pathogenic free-living amoebae in freshwater lakes.

scientific article published in February 1985

WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys

scientific article published on May 1997

World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility

scientific article published on 6 September 2007

pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines

scientific article published on November 2003