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List of works by David L. Narum

A Method for Producing Protein Nanoparticles with Applications in Vaccines

scientific article

A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

scientific article published on 19 March 2021

A malaria vaccine protects Aotus monkeys against virulent Plasmodium falciparum infection

scientific article published on 22 May 2017

A novel Plasmodium falciparum erythrocyte binding protein-2 (EBP2/BAEBL) involved in erythrocyte receptor binding

scientific article published in February 2002

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

scientific article

A recombinant baculovirus-expressed Plasmodium falciparum receptor-binding domain of erythrocyte binding protein EBA-175 biologically mimics native protein. ⬇️

scientific article published on June 2000

Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixture

scientific article published in February 2002

Accelerated and long term stability study of Pfs25-EPA conjugates adjuvanted with Alhydrogel®.

scientific article published on 4 May 2017

Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders

scientific article published on 27 March 2008

Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo

scientific article

Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP

scientific article

Analysis of the processing of Plasmodium falciparum rhoptry-associated protein 1 and localization of Pr86 to schizont rhoptries and p67 to free merozoites

article

Antibodies against the Plasmodium falciparum receptor binding domain of EBA-175 block invasion pathways that do not involve sialic acids ⬇️

scientific article published on April 2000

Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic

scientific article

Antibodies to Plasmodium falciparum antigens vary by age and antigen in children in a malaria-holoendemic area of Kenya

scientific article published in August 2005

Antibodies to Plasmodium falciparum erythrocyte-binding antigen-175 are associated with protection from clinical malaria

scientific article published on December 2011

Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia

scientific article published in October 2010

Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion

scientific article

Binding of aldolase and glyceraldehyde-3-phosphate dehydrogenase to the cytoplasmic tails of Plasmodium falciparum merozoite duffy binding-like and reticulocyte homology ligands

scientific article

Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection

scientific article

Can prenatal malaria exposure produce an immune tolerant phenotype? A prospective birth cohort study in Kenya

scientific article

Characterisation of the rhoph2 gene of Plasmodium falciparum and Plasmodium yoelii

scientific article

Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure

scientific article published on 27 November 2008

Codon optimization of gene fragments encoding Plasmodium falciparum merzoite proteins enhances DNA vaccine protein expression and immunogenicity in mice.

scientific article

Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: a strategy for enhancing immunogenicity of malaria vaccine candidates

scientific article published on 13 March 2007

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort

scientific article published on 9 December 2015

Corrigendum to “Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer” [Vaccine 30 (2012) 189–194]

scholarly article by Daming Zhu et al published May 2013 in Vaccine

Decrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells

scientific article

Delineation of stage specific expression of Plasmodium falciparum EBA-175 by biologically functional region II monoclonal antibodies

scientific article

Determination of protein concentration for protein-protein conjugates using ultraviolet absorption

scientific article

Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticle

scientific article

Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites.

scientific article published in September 1994

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

scientific article published on 11 November 2016

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

scientific article

Effect of seasonal malaria chemoprevention on the acquisition of antibodies to Plasmodium falciparum antigens in Ouelessebougou, Mali

scientific article

Efficient extraction of vaccines formulated in aluminum hydroxide gel by including surfactants in the extraction buffer

scientific article published on 19 November 2011

Endostatin binds tropomyosin. A potential modulator of the antitumor activity of endostatin.

scientific article published on 2 May 2001

Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens

scientific article

Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA.

scientific article published on 4 February 2008

Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers

scientific article published on February 2008

Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection

scientific article

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development

scientific article published on 17 June 2013

Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay

scientific article published on 23 January 2013

Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display

scientific article published on 6 July 2015

Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes

scientific article

Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria

scientific article

Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection

scientific article

Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1

scientific article

Ion-exchange—immunoaffinity purification of a recombinant baculovirus Plasmodium falciparum apical membrane antigen, PF83/AMA-1

scientific article published on 01 December 1993

Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25.

scholarly article

Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission

scientific article published on 22 September 2008

Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival

scientific article

Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

scientific article

Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting

scientific article published on 10 February 2016

Molecular characterisation of Plasmodium reichenowi apical membrane antigen-1 (AMA-1), comparison with P. falciparum AMA-1, and antibody-mediated inhibition of red cell invasion.

scientific article published on July 2000

NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity.

scientific article

NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria

scientific article published on 30 December 2013

New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women

scientific article

Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris

scientific article published on 29 June 2009

Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.

scientific article published on 19 February 2013

Particle-based platforms for malaria vaccines

scientific article

Passive immunization with a multicomponent vaccine against conserved domains of apical membrane antigen 1 and 235-kilodalton rhoptry proteins protects mice against Plasmodium yoelii blood-stage challenge infection. ⬇️

scientific article

Phase 1 study in malaria naïve adults of BSAM2/Alhydrogel®+CPG 7909, a blood stage vaccine against P. falciparum malaria

scientific article

Phase 1 study of two merozoite surface protein 1 (MSP1(42)) vaccines for Plasmodium falciparum malaria

scientific article

Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.

scientific article

Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults

scientific article (publication date: 22 January 2010)

Plasmodium berghei ookinete densities in three anopheline species

scientific article published in October 1991

Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P

scientific article (publication date: 3 April 2012)

Precise Timing of Expression of a Plasmodium falciparum- derived Transgene in Plasmodium berghei Is a Critical Determinant of Subsequent Subcellular Localization ⬇️

scientific article published on June 12, 1998

Production and characterization of clinical grade Escherichia coli derived Plasmodium falciparum 42 kDa merozoite surface protein 1 (MSP1(42)) in the absence of an affinity tag.

scientific article published on 27 June 2006

Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen

scientific article published on 8 December 2000

Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens.

scientific article

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults

scientific article

Screen-less expanded bed column: new approach for the recovery and purification of a malaria transmission blocking vaccine candidate from Pichia pastoris.

scientific article published on 20 June 2006

Sequence diversity and antigenic polymorphism in the Plasmodium yoelii p235 high molecular mass rhoptry proteins and their genes

scientific article published in February 2001

Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo

scientific article

Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230.

scientific article

Structural and immunological analysis of anthrax recombinant protective antigen adsorbed to aluminum hydroxide adjuvant.

scientific article

Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

scientific article published on 24 July 2020

Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate

scientific article

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.

scientific article

The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections

scientific article

The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.

scientific article

The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals

scientific article

The epitope of monoclonal antibodies blocking erythrocyte invasion by Plasmodium falciparum map to the dimerization and receptor glycan binding sites of EBA-175. ⬇️

scientific article

VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria

scientific article published on 18 May 2016

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