List of works - Gaetan Chicanne

A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.

scientific article published on 10 May 2010

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

scientific article

Antileukemic activity of rapamycin in acute myeloid leukemia.

scientific article published on 18 November 2004

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

scientific article

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

scientific article published on 11 January 2010

Different roles of SHIP1 according to the cell context: the example of blood platelets.

scientific article

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

scientific article published on 01 July 2020

Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve

scientific article

Essential role of class II PI3K-C2α in platelet membrane morphology

scientific article

Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.

scientific article

Functional Characterization and Rescue of a Deep Intronic Mutation in OCRL Gene Responsible for Lowe Syndrome.

scientific article published on 28 October 2016

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies

scientific article

Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ecto-phospholipase C acting as an endocannabinoid signaling switch

scientific article published on 11 September 2020

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

scientific article

Mass Assays to Quantify Bioactive PtdIns3P and PtdIns5P During Autophagic Responses.

scientific article published on 18 November 2016

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis ⬇️

scientific article published on October 3, 2011

Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo

scientific article published on 26 February 2013

PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions

scientific article published on 29 March 2016

Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice

scientific article

Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis

scientific article (publication date: February 2011)

Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast.

scientific article

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

scientific article

Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation

scientific article published on 21 March 2018

Phosphoinositides: Important lipids in the coordination of cell dynamics

scientific article published on 18 September 2015

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation

scientific article published on 12 June 2018

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

scientific article published in July 2009

Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization

scientific article published on 13 October 2009

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions

scientific article

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

scientific article published in Nature Communications

Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

scientific article published in September 2011

TOM1 is a PI5P effector involved in the regulation of endosomal maturation

scientific article

The Nucleophosmin-Anaplastic Lymphoma Kinase Oncogene Interacts, Activates, and Uses the Kinase PIKfyve to Increase Invasiveness ⬇️

scientific article published on 07 July 2011

The importance of blood platelet lipid signaling in thrombosis and in sepsis.

scientific article published on 29 September 2017

The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis

scientific article published on 02 December 2015

Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils.

scientific article published on 20 December 2016

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

scientific article published on 27 November 2017

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

scientific article published on 23 December 2013

List of works by Gaetan Chicanne

A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Antileukemic activity of rapamycin in acute myeloid leukemia.

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

Different roles of SHIP1 according to the cell context: the example of blood platelets.

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve

Essential role of class II PI3K-C2α in platelet membrane morphology

Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.

Functional Characterization and Rescue of a Deep Intronic Mutation in OCRL Gene Responsible for Lowe Syndrome.

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies

Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ecto-phospholipase C acting as an endocannabinoid signaling switch

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

Mass Assays to Quantify Bioactive PtdIns3P and PtdIns5P During Autophagic Responses.

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis ⬇️

Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo

PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions

Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice

Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis

Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast.

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.

Phosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation

Phosphoinositides: Important lipids in the coordination of cell dynamics

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

TOM1 is a PI5P effector involved in the regulation of endosomal maturation

The Nucleophosmin-Anaplastic Lymphoma Kinase Oncogene Interacts, Activates, and Uses the Kinase PIKfyve to Increase Invasiveness ⬇️

The importance of blood platelet lipid signaling in thrombosis and in sepsis.

The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis

Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.