List of works by Michael Brines

A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets.

scientific article published on 17 December 2015

A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema

scientific article published on 14 July 2020

A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock.

scientific article

A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage.

scientific article

ARA 290 for treatment of small fiber neuropathy in sarcoidosis.

scientific article published on 21 February 2014

ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density

scientific article

ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.

scientific article

ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response

scientific article (publication date: 16 February 2014)

ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability.

scientific article published on 11 May 2016

ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and β-common receptor knockout mice.

scientific article

Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative

scientific article published on 01 April 2006

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

scholarly article

Anthropometric variables accurately predict dual energy x-ray absorptiometric-derived body composition and can be used to screen for diabetes

scientific article (publication date: 2011)

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

scientific article

Bees have rules

scientific article published on 01 November 1979

Behavioral method for the treatment of idiopathic scoliosis.

scientific article published on April 1985

Cell-type specific expression of Na+, K(+)-ATPase catalytic subunits in cultured neurons and glia: evidence for polarized distribution in neurons

scientific article published on 01 December 1993

Characterization of canine renal receptors for the parathyroid hormone-like protein associated with humoral hypercalcemia of malignancy

scientific article published on 01 April 1989

Chronic administration of small nonerythropoietic peptide sequence of erythropoietin effectively ameliorates the progression of postmyocardial infarction-dilated cardiomyopathy

scientific article

Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis

scientific article published on 12 October 2017

Clinical case seminar: Cushing's syndrome in an elderly woman with large thyroid and pituitary masses

scientific article published on 01 February 1996

Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia.

scientific article published on 23 March 2016

Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy.

scientific article published on 16 March 2018

Cytoarchitectural relationships between [3H]ouabain binding and mRNA for isoforms of the sodium pump catalytic subunit in rat brain.

scientific article

Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities.

scholarly article

Discovery of a master regulator of injury and healing: tipping the outcome from damage toward repair.

scientific article

Dynamic patterns of skylight polarization as clock and compass.

scientific article published in October 1980

Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia.

scientific article

Endogenous parathyroid hormone-related protein functions as a neuroprotective agent.

scientific article published in March 2002

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury.

scientific article

Erythropoietin and engineered innate repair activators.

scientific article published in January 2013

Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin

scientific article published on 01 April 2005

Erythropoietin as a tissue-protective cytokine in brain injury: what do we know and where do we go?

scientific article published on April 2004

Erythropoietin as an antiapoptotic, tissue-protective cytokine.

scientific article published in July 2004

Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor.

scientific article

Erythropoietin both protects from and reverses experimental diabetic neuropathy

scholarly article

Erythropoietin is a multifunctional tissue-protective cytokine ⬇️

scientific article published on November 1, 2003

Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection

scholarly article

Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury

scientific article

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

scientific article

Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis

scientific article published in September 2003

Erythropoietin therapy for acute stroke is both safe and beneficial

scientific article

Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties.

scientific article

Erythropoietin: not just about erythropoiesis

scientific article published on June 2010

Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin

scientific article

Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampus.

scientific article published in May 1998

Glutamate up-regulates alpha 1 and alpha 2 subunits of the sodium pump in astrocytes of mixed telencephalic cultures but not in pure astrocyte cultures

scientific article published on 01 December 1993

Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis

scientific article published on 01 January 2004

Inhibition of alpha 2/alpha 3 sodium pump isoforms potentiates glutamate neurotoxicity

scientific article published on September 18, 1992

Ketamine does not produce relief of neuropathic pain in mice lacking the β-common receptor (CD131).

scientific article

Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury.

scientific article

Neurochemical remodelling of the hippocampus in human temporal lobe epilepsy.

scientific article

Neuroprotective properties of epoetin alfa.

scientific article

Neurotransmitters and their receptors in human temporal lobe epilepsy

scientific article published on January 1, 1992

Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing.

scientific article published on 16 April 2009

Parathyroid hormone modulates angiotensin II-induced aldosterone secretion from the adrenal glomerulosa cell

scientific article published on 01 July 1991

Parathyroid hormone-related protein markedly potentiates depolarization-induced catecholamine release in PC12 cells via L-type voltage-sensitive Ca2+ channels

scientific article published on 01 February 1999

Parathyroid hormone-related protein protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux

scientific article published on 01 October 1999

Promises and pitfalls in erythopoietin-mediated tissue protection: are nonerythropoietic derivatives a way forward?

scientific article

Protective Effect of Erythropoietin and Its Carbamylated Derivative in Experimental Cisplatin Peripheral Neurotoxicity

scientific article published on 01 April 2006

Recombinant human erythropoietin for neuroprotection: what is the evidence?

scientific article

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

scholarly article

Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives

scientific article published on 12 July 2006

Regional distributions of hippocampal Na+,K(+)-ATPase, cytochrome oxidase, and total protein in temporal lobe epilepsy

scientific article published on 01 April 1995

Reply to Abdelwahid and Smith: The effect on cardiomyocytes of helix B-surface peptide (HBSP), a peptide with cell-protective but not erythropoietic activities of erythropoietin.

scientific article

Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study

scientific article published on 15 November 2012

Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.

scientific article published on 24 July 2013

TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury

scholarly article

The A2 isoform of rat Na+,K(+)-adenosine triphosphatase is active and exhibits high ouabain affinity when expressed in transfected fibroblasts

scientific article published on June 1, 1992

The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase ⬇️

scientific article published on January 1, 1992

The cardiac glycoside ouabain potentiates excitotoxic injury of adult neurons in rat hippocampus

scientific article published on 01 May 1995

The mast cell plays a central role in the immune system of teleost fish

scientific article published on 07 March 2014

The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors.

scientific article published on 08 January 2010

Thyrotropin-secreting adenoma in an adolescent girl without increased serum thyrotropin-alpha

scientific article published on 01 January 1994

Transcripts of the transposon mariner are present in epileptic brain.

scientific article published in September 1998

Vasoactive intestinal polypeptide and its receptor changes in human temporal lobe epilepsy

scientific article published on 01 July 1995

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

scientific article published on April 1994

What evidence supports use of erythropoietin as a novel neurotherapeutic?

scientific article

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