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List of works by Pradeep Natarajan

A New Murine Model of Clonal Hematopoiesis Investigates JAK2 V617F in Heart Failure

scientific article published on 28 October 2019

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

scientific article

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

scientific article published on 28 January 2016

A statistical framework for cross-tissue transcriptome-wide association analysis

scientific article published on 25 February 2019

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

scientific article published on 29 March 2017

Aggregate penetrance of genomic variants for actionable disorders in European and African Americans

scientific article published on November 2016

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

scientific article published on 24 April 2018

Analysis of protein-coding genetic variation in 60,706 humans

scientific article (publication date: 17 August 2016)

Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study

scientific article published in November 2015

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

scientific article

Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death

scientific article published on 01 May 2019

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

scientific article

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

scientific article

Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week

scientific article published on 01 July 2019

Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis

scientific article published on 01 July 2018

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

scientific article published on 29 May 2021

Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation

scientific article published on 01 April 2019

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

scientific article published on 28 December 2016

Could Direct Inhibition of Inflammation Be the “Next Big Thing” in Treating Atherosclerosis?

scientific article published on 01 November 2010

DNA Sequence Variation in Encoding the Activin-Receptor Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

scientific article

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

article published in 2017

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

scientific article published in Nature Communications

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

Development of a clinical polygenic risk score assay and reporting workflow

scientific article published on 18 April 2022

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

scientific article

Digital Health for Primary Prevention of Cardiovascular Disease: Promise to Practice

scientific article published on 19 September 2020

Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease.

scientific article published on 28 October 2015

Distinction of lymphoid and myeloid clonal hematopoiesis

scientific article published on 18 October 2021

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

scientific article published on 24 August 2020

Effect of hospitalist attending physicians on trainee educational experiences: a systematic review.

scientific article published on October 2009

Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program

scientific article published on 01 December 2018

Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.

scientific article

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort

scientific article

Gene-gene Interaction Analyses for Atrial Fibrillation

scientific article

Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease

scientific article published on 01 June 2019

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

scientific article published on February 2017

Genetic Link Between Arterial Stiffness and Atrial Fibrillation

scientific article published on 18 June 2019

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

scientific article

Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy

scientific article published on 17 August 2020

Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.

scientific article

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

scientific article published on 13 June 2018

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

article

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

scientific article published on 01 November 2019

Genome-wide association study of peripheral artery disease in the Million Veteran Program

scientific article published on 08 July 2019

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

article by Amit V Khera et al published September 2018 in Nature Genetics

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

scientific article published on 30 August 2020

High-density lipoprotein and coronary heart disease: current and future therapies.

scientific article published on March 2010

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

scientific article published on April 2017

Human knockouts in a cohort with a high rate of consanguinity

Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1.

scientific article published on 29 March 2004

Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article

Increased CHIP Prevalence Amongst People Living with HIV

scientific article published on 07 November 2020

Influence of blood pressure on pneumonia risk: Epidemiological association and Mendelian randomisation in the UK Biobank

scientific article published on 23 April 2020

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

scientific article published on 14 October 2020

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

scientific article published on 14 October 2020

Insights from population-based analyses of plasma lipids across the allele frequency spectrum

scientific article published on 12 February 2018

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

scientific article published on 21 November 2016

Myocardial infarction vaccine? Evidence supporting the influenza vaccine for secondary prevention

article

Optimal Non-invasive Strategies to Reduce Recurrent Atherosclerotic Cardiovascular Disease Risk

scientific article published on 29 June 2019

Outcomes of a smartphone-based application with live health-coaching post-percutaneous coronary intervention

scientific article published on 14 October 2021

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

scientific article published on 09 November 2020

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

scientific article published on December 2016

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

scientific article published on 5 October 2017

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

scientific article published on 21 February 2017

Polygenic Risk Scoring for Coronary Heart Disease: The First Risk Factor

article

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Therapy: Payer Approvals and Rejections, and Patient Characteristics for Successful Prescribing

scientific article published on 30 October 2017

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

scientific article published on 15 May 2017

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

scientific article published in 2022

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

scientific article published in Nature Communications

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

scientific article published on 01 April 2020

Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia

scientific article published on 01 October 2018

Reducing Cardiovascular Risk Using Genomic Information in the Era of Precision Medicine.

scientific article published on 25 February 2016

Risk Factors and Outcomes of Very Young Adults Who Experience Myocardial Infarction: The Partners YOUNG-MI Registry

scientific article published on 09 November 2019

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

scientific article published on 6 March 2019

The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism?

scientific article

Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano).

scientific article published on September 2002

Transcriptomic signatures across human tissues identify functional rare genetic variation

scientific article

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

scientific article published on 03 October 2016

Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction

scientific article published on 01 March 2019

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