List of works - Christopher C. Miller

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

scientific article published on 7 March 2013

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

scientific article published on 14 July 2016

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

scientific article published on 24 February 2010

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria ⬇️

scientific article published on January 17, 2012

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter

scientific article

Androgen induced cell death in SHSY5Y neuroblastoma cells expressing wild-type and spinal bulbar muscular atrophy mutant androgen receptors.

scientific article

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

scientific article

Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration.

scientific article published on 10 April 2018

Cdk5/p35 phosphorylates lemur tyrosine kinase‐2 to regulate protein phosphatase‐1C phosphorylation and activity ⬇️

scientific article published on May 1, 2012

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

scientific article

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production ⬇️

scientific article published on January 1, 2010

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

scientific journal article

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

scientific journal article

Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis.

scientific article published on 28 February 2018

Dissociation of Axonal Neurofilament Content from Its Transport Rate

scientific article published on 24 July 2015

ER-mitochondria signaling regulates autophagy

scientific article published on 26 May 2017

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

scientific article published in April 2004

Expression of the Fe65 adapter protein in adult and developing mouse brain.

scientific article published in January 2002

FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing

scientific article published on 01 October 2019

GULP1 is a novel APP-interacting protein that alters APP processing.

scientific article published in June 2011

Gigaxonin is associated with the Golgi and dimerises via its BTB domain.

scientific article published in April 2004

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

scientific article

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

scientific article published on 05 December 2019

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains

scientific article published on 08 May 2019

Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter.

scientific article

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

scientific article (publication date: 27 February 2009)

Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

scientific article

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

scientific article published on May 2003

Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.

scientific article published on 14 January 2009

Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival

scientific article published on 10 August 2020

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

scientific article published in March 2004

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

scientific article published on 17 July 2015

Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

scientific article published on 01 December 1999

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

scientific article published on 3 March 2009

Role of axonal transport in neurodegenerative diseases

scientific article

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

scientific article

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

scientific article published on 18 January 2017

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

scientific article published on 03 September 2004

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

scientific article published on 06 March 2019

The X11 proteins, Abeta production and Alzheimer's disease.

scientific article

The X11/Mint family of adaptor proteins.

scientific article published on 9 June 2006

The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function

scientific article

The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies.

scientific article published on 06 February 2009

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

scientific article published in December 2003

The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures

scientific article published on August 1995

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

scientific article published in June 2004

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production

scientific article

List of works by Christopher C. Miller

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria ⬇️

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter

Androgen induced cell death in SHSY5Y neuroblastoma cells expressing wild-type and spinal bulbar muscular atrophy mutant androgen receptors.

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration.

Cdk5/p35 phosphorylates lemur tyrosine kinase‐2 to regulate protein phosphatase‐1C phosphorylation and activity ⬇️

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production ⬇️

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis.

Dissociation of Axonal Neurofilament Content from Its Transport Rate

ER-mitochondria signaling regulates autophagy

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

Expression of the Fe65 adapter protein in adult and developing mouse brain.

FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing

GULP1 is a novel APP-interacting protein that alters APP processing.

Gigaxonin is associated with the Golgi and dimerises via its BTB domain.

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains

Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter.

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments.

Nox4 regulates InsP3 receptor-dependent Ca2+ release into mitochondria to promote cell survival

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription

Riluzole protects against glutamate-induced slowing of neurofilament axonal transport.

Role of axonal transport in neurodegenerative diseases

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

The X11 proteins, Abeta production and Alzheimer's disease.

The X11/Mint family of adaptor proteins.

The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function

The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies.

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production