List of works - Aki Manninen

3D Cell Culture Models of Epithelial Tissues

scientific article published on 01 January 2019

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

scientific article

A proteomics view on integrin-mediated adhesions

scientific article

Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta

scientific article

Assembly of the β4-integrin interactome based on proximal biotinylation in the presence and absence of heterodimerization

scientific article published on 07 November 2018

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

scientific article

BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity in hypoxia.

scientific article published on 23 April 2018

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease

scientific article published on 01 December 2018

Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

Caveolin-1 is not essential for biosynthetic apical membrane transport

scientific article published on November 2005

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

scientific article published on 17 June 2008

Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy

scientific article published on 3 August 2007

Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis.

scientific article published on 29 June 2010

Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis

scientific article

Epithelial polarity--generating and integrating signals from the ECM with integrins

scientific article

FAPP2 is involved in the transport of apical cargo in polarized MDCK cells

scientific article

Focus prediction in digital holographic microscopy using deep convolutional neural networks

scientific article published on 01 February 2019

Functional genetic targeting of embryonic kidney progenitor cells ex vivo.

scientific article

Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.

scientific article published on 19 September 2008

Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells

scientific article

Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference

scholarly article

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

scientific article

HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells

scientific article

HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.

scientific article published on April 2015

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

scientific article

Identification of the Nef-associated kinase as p21-activated kinase 2

scientific article

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

scientific article published on 28 September 2018

Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.

scientific article

Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells.

scientific article published on 26 October 2011

Laminins in Epithelial Cell Polarization: Old Questions in Search of New Answers

scientific article published on 3 February 2017

Meta-analysis of gene expression and integrin-associated signaling pathways in papillary renal cell carcinoma subtypes.

scientific article published on October 2016

NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease.

scientific article published on 8 February 2018

Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.

scientific article published on 12 June 2017

Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells

scientific article published on 21 November 2006

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB

scientific article (publication date: 25 May 2003)

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

scientific article

Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes

scientific article published on 03 June 2019

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking.

scientific article

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.

scientific article published on 22 March 2017

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2

scientific article published on 29 May 2019

Two distinct integrin-mediated mechanisms contribute to apical lumen formation in epithelial cells

scientific article

α6β1- and αV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF

scientific article

αV-integrins are required for mechanotransduction in MDCK epithelial cells

scientific article (publication date: 2013)

List of works by Aki Manninen

3D Cell Culture Models of Epithelial Tissues

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

A proteomics view on integrin-mediated adhesions

Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta

Assembly of the β4-integrin interactome based on proximal biotinylation in the presence and absence of heterodimerization

Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage

BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity in hypoxia.

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease

Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

Caveolin-1 is not essential for biosynthetic apical membrane transport

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy

Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis.

Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis

Epithelial polarity--generating and integrating signals from the ECM with integrins

FAPP2 is involved in the transport of apical cargo in polarized MDCK cells

Focus prediction in digital holographic microscopy using deep convolutional neural networks

Functional genetic targeting of embryonic kidney progenitor cells ex vivo.

Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.

Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells

Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells

HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

Identification of the Nef-associated kinase as p21-activated kinase 2

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.

Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells.

Laminins in Epithelial Cell Polarization: Old Questions in Search of New Answers

Meta-analysis of gene expression and integrin-associated signaling pathways in papillary renal cell carcinoma subtypes.

NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease.

Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.

Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking.

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells.

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2

Two distinct integrin-mediated mechanisms contribute to apical lumen formation in epithelial cells

α6β1- and αV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF

αV-integrins are required for mechanotransduction in MDCK epithelial cells