List of works - Lars M Steinmetz

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle ⬇️

scientific article (publication date: July 1998)

A genome-wide map of mitochondrial DNA recombination in yeast

scientific article published on 31 July 2014

A high-resolution map of transcription in the yeast genome

scientific article published on 28 March 2006

A high-throughput ChIP-Seq for large-scale chromatin studies

scientific article

A privacy-preserving solution for compressed storage and selective retrieval of genomic data

scientific article

A yeast-based assay identifies drugs active against human mitochondrial disorders

scientific article

Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae.

scientific article

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions.

scientific article

An efficient method for genome-wide polyadenylation site mapping and RNA quantification.

scientific article

An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae

scientific article published on 27 December 2013

Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen

scientific article

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D.

scientific article

Antisense expression increases gene expression variability and locus interdependency

scientific article

Array-based genotyping in S.cerevisiae using semi-supervised clustering

scientific article published on 23 February 2009

Assessing systems properties of yeast mitochondria through an interaction map of the organelle

scientific article

Bidirectional promoters generate pervasive transcription in yeast

scientific article (publication date: 19 February 2009)

Capturing cellular machines by systematic screens of protein complexes

scientific article published on 16 June 2006

Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast

scientific article published on 18 November 2019

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

scientific article published on 23 December 2019

Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

scientific article published on 23 November 2020

Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes

article

Complex genetic interactions in a quantitative trait locus

scientific article

Control of Cdc28 CDK1 by a stress-induced lncRNA

scientific article

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

scientific article published on 01 March 2019

Dissecting the architecture of a quantitative trait locus in yeast

scientific article published in March 2002

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae

scientific article published on October 2009

Drift and conservation of differential exon usage across tissues in primate species

scientific article published on 03 September 2013

Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

scientific article published on 13 November 2020

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae

scientific article

Evolthon: A community endeavor to evolve lab evolution

scientific article published on 29 March 2019

Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6

scientific article

Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution

scientific article

Extensive degradation of RNA precursors by the exosome in wild-type cells

scientific article

Extensive transcriptional heterogeneity revealed by isoform profiling

scientific article published on 24 April 2013

Extensive variation in chromatin states across humans

scientific article

Functional consequences of bidirectional promoters

scientific article

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

scientific article published on 14 August 2020

Gene function on a genomic scale

article

Gene loops enhance transcriptional directionality

scientific article published on 27 September 2012

Gene regulation by antisense transcription

scientific article

Genetic analysis of variation in transcription factor binding in yeast

scientific article published on 17 March 2010

Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms

scientific article

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789.

scholarly article

Genome-Wide Transcriptome Analysis in Yeast Using High-Density Tiling Arrays

article

Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange

scientific article

Genome-wide allele- and strand-specific expression profiling

scientific article published on 16 June 2009

Genome-wide identification of transcript start and end sites by transcript isoform sequencing

scientific article

Genome-wide polyadenylation site mapping

scientific article

Genome-wide survey of post-meiotic segregation during yeast recombination

scientific article published on 11 April 2011

Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype

scientific article

Genotyping 1000 yeast strains by next-generation sequencing

scientific article

Heritability and genetic basis of protein level variation in an outbred population

scientific article

High-density arrays and insights into genome function.

scientific article

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

scientific article

High-resolution transcription atlas of the mitotic cell cycle in budding yeast

scientific article (publication date: 2010)

Identification of mitochondrial disease genes through integrative analysis of multiple datasets

scientific article published on 16 October 2008

Induced mutations in yeast cell populations adapting to an unforeseen challenge

scientific article

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

scientific article

Integrative analysis of the mitochondrial proteome in yeast

scientific article

KIR<sup>+</sup>CD8<sup>+</sup> T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

scientific article published on 15 April 2022

Maximizing the potential of functional genomics

scientific article published on March 2004

Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.

scientific article published on 17 June 2016

Mosaic genome architecture of the Anopheles gambiae species complex

scientific article

Multiple genomic changes associated with reorganization of gene regulation and adaptation in yeast

scientific article published on 14 April 2013

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

scientific article published on 08 October 2013

Natural single-nucleosome epi-polymorphisms in yeast.

scientific article

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality.

scientific article

RNA degradation analysis reveals ribosome dynamics in complex microbiome samples

scientific article published on 10 April 2021

RNA polymerase II collision interrupts convergent transcription

scientific article

Re-analysis of data and its integration

scientific article (publication date: 12 February 2005)

Role of duplicate genes in genetic robustness against null mutations

scientific article (publication date: 2 January 2003)

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast.

scientific article published on 04 February 2014

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins

scientific article

Sensitive high-throughput single-cell RNA-seq reveals within-clonal transcript correlations in yeast populations

scientific article published on 04 February 2019

Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast

scientific article published on 09 September 2008

Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics.

scientific article

Silencing of genes and alleles by RNAi in Anopheles gambiae

scientific article published in January 2013

Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum

scientific article published in 2024

System-wide identification of RNA-binding proteins by interactome capture.

scientific article

Systematic screen for human disease genes in yeast

scientific article (publication date: August 2002)

Systematic screens for human disease genes, from yeast to human and back

scientific article published on 25 September 2007

Targeted Perturb-seq enables genome-scale genetic screens in single cells

scientific article published on 01 June 2020

The Not5 subunit of the ccr4-not complex connects transcription and translation

scientific article

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

scientific article

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis

scientific article

The genomic and transcriptomic landscape of a HeLa cell line

scientific article

The role of Ctk1 kinase in termination of small non-coding RNAs

scientific article (publication date: 2013)

Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae

scientific article published on July 2009

Transcript mapping with high-density oligonucleotide tiling arrays

scientific article published on 20 June 2006

Transcription mediated insulation and interference direct gene cluster expression switches

scientific article

Ultrasensitive proteome analysis using paramagnetic bead technology

scientific article

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

scientific article

Yeast Sen1 helicase protects the genome from transcription-associated instability.

scientific article

Yeast growth plasticity is regulated by environment-specific multi-QTL interactions

scientific article

easyRNASeq: a bioconductor package for processing RNA-Seq data

scientific article

List of works by Lars M Steinmetz

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle ⬇️

A genome-wide map of mitochondrial DNA recombination in yeast

A high-resolution map of transcription in the yeast genome

A high-throughput ChIP-Seq for large-scale chromatin studies

A privacy-preserving solution for compressed storage and selective retrieval of genomic data

A yeast-based assay identifies drugs active against human mitochondrial disorders

Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae.

Alternative polyadenylation diversifies post-transcriptional regulation by selective RNA-protein interactions.

An efficient method for genome-wide polyadenylation site mapping and RNA quantification.

An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae

Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D.

Antisense expression increases gene expression variability and locus interdependency

Array-based genotyping in S.cerevisiae using semi-supervised clustering

Assessing systems properties of yeast mitochondria through an interaction map of the organelle

Bidirectional promoters generate pervasive transcription in yeast

Capturing cellular machines by systematic screens of protein complexes

Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

Combined transient ablation and single cell RNA sequencing reveals the development of medullary thymic epithelial cells

Combining genome sequences and new technologies for dissecting the genetics of complex phenotypes

Complex genetic interactions in a quantitative trait locus

Control of Cdc28 CDK1 by a stress-induced lncRNA

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

Dissecting the architecture of a quantitative trait locus in yeast

Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae

Drift and conservation of differential exon usage across tissues in primate species

Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae

Evolthon: A community endeavor to evolve lab evolution

Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6

Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution

Extensive degradation of RNA precursors by the exosome in wild-type cells

Extensive transcriptional heterogeneity revealed by isoform profiling

Extensive variation in chromatin states across humans

Functional consequences of bidirectional promoters

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

Gene function on a genomic scale

Gene loops enhance transcriptional directionality

Gene regulation by antisense transcription

Genetic analysis of variation in transcription factor binding in yeast

Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789.

Genome-Wide Transcriptome Analysis in Yeast Using High-Density Tiling Arrays

Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange

Genome-wide allele- and strand-specific expression profiling

Genome-wide identification of transcript start and end sites by transcript isoform sequencing

Genome-wide polyadenylation site mapping

Genome-wide survey of post-meiotic segregation during yeast recombination

Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype

Genotyping 1000 yeast strains by next-generation sequencing

Heritability and genetic basis of protein level variation in an outbred population

High-density arrays and insights into genome function.

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

High-resolution transcription atlas of the mitotic cell cycle in budding yeast

Identification of mitochondrial disease genes through integrative analysis of multiple datasets

Induced mutations in yeast cell populations adapting to an unforeseen challenge

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

Integrative analysis of the mitochondrial proteome in yeast

KIR<sup>+</sup>CD8<sup>+</sup> T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Maximizing the potential of functional genomics

Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.

Mosaic genome architecture of the Anopheles gambiae species complex

Multiple genomic changes associated with reorganization of gene regulation and adaptation in yeast

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

Natural single-nucleosome epi-polymorphisms in yeast.

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality.

RNA degradation analysis reveals ribosome dynamics in complex microbiome samples

RNA polymerase II collision interrupts convergent transcription

Re-analysis of data and its integration

Role of duplicate genes in genetic robustness against null mutations

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast.

Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins

Sensitive high-throughput single-cell RNA-seq reveals within-clonal transcript correlations in yeast populations

Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast

Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics.

Silencing of genes and alleles by RNAi in Anopheles gambiae

Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum

System-wide identification of RNA-binding proteins by interactome capture.