List of works - Xiao-chen Bai

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

scientific article published on 22 August 2019

An atomic structure of human γ-secretase

scientific journal article

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

scientific article published on 26 May 2021

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

scientific article

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

scholarly article

Cellular internalization of exosomes occurs through phagocytosis

scientific article

Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins

scientific article published on September 2011

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

scientific article published on 19 September 2019

Cryo-EM structure of a 3D DNA-origami object

scientific article

Cryo-EM structure of a fungal mitochondrial calcium uniporter

scientific article published in Nature

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

scientific article published on 6 March 2017

Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution

Cryo-EM structure of mouse TPC1 channel in the apo state

Cryo-EM structure of the Hippo signaling integrator human STRIPAK

scientific article published on 25 February 2021

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

scientific article

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

scientific article published on 23 April 2020

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

scientific article published on 14 May 2020

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

scientific article published on February 2016

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

scientific article published on 06 March 2019

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

scientific article published on 29 July 2020

Cryo-EM structures of the human cation-chloride cotransporter KCC1

scientific article published on 01 October 2019

Design of a molecular support for cryo-EM structure determination

scientific article

How cryo-EM is revolutionizing structural biology

scientific article

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

scientific article

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.

scientific article published on 31 January 2017

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

scientific article

Molecular architecture of a eukaryotic translational initiation complex

scientific article

Molecular mechanism of the wake-promoting agent TAK-925

scientific article published on 25 May 2022

Overexpression of complexin in PC12 cells inhibits exocytosis by preventing SNARE complex recycling

scientific article published on 01 April 2007

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

scientific article (publication date: 19 February 2013)

Sampling the conformational space of the catalytic subunit of human γ-secretase

scientific article

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

scientific article published on 09 May 2019

Structural and functional characterization of an otopetrin family proton channel

scientific article published on 11 April 2019

Structural basis of STING binding with and phosphorylation by TBK1

scientific article published on 06 March 2019

Structural basis of the activation of type 1 insulin-like growth factor receptor

scientific article published on 08 October 2019

Structural characterization of full-length NSF and 20S particles

scientific article published on 5 February 2012

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

scientific article published on 07 August 2020

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.

scientific article published on 21 March 2018

Structural mechanisms of phospholipid activation of the human TPC2 channel

scientific article published on 12 March 2019

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

scientific article published on 11 June 2020

Structure of a spliceosome remodelled for exon ligation

scientific article published on 11 January 2017

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

scientific article published on 11 October 2017

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.

scientific article published on 15 May 2017

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

scientific article

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila

scientific article

Structure of the large ribosomal subunit from human mitochondria.

scientific article

Structures of the calcium-activated, non-selective cation channel TRPM4.

scientific article published on 6 December 2017

Structures of the human mitochondrial ribosome in native states of assembly.

scientific article published on 11 September 2017

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

scientific article published on 29 July 2016

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region

scientific article published on 12 July 2016

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

scientific article

Three-dimensional structure of human γ-secretase

scientific article

List of works by Xiao-chen Bai

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

An atomic structure of human γ-secretase

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

Cellular internalization of exosomes occurs through phagocytosis

Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

Cryo-EM structure of a 3D DNA-origami object

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution

Cryo-EM structure of mouse TPC1 channel in the apo state

Cryo-EM structure of the Hippo signaling integrator human STRIPAK

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

Cryo-EM structures of the human cation-chloride cotransporter KCC1

Design of a molecular support for cryo-EM structure determination

How cryo-EM is revolutionizing structural biology

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Molecular architecture of a eukaryotic translational initiation complex

Molecular mechanism of the wake-promoting agent TAK-925

Overexpression of complexin in PC12 cells inhibits exocytosis by preventing SNARE complex recycling

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

Sampling the conformational space of the catalytic subunit of human γ-secretase

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

Structural and functional characterization of an otopetrin family proton channel

Structural basis of STING binding with and phosphorylation by TBK1

Structural basis of the activation of type 1 insulin-like growth factor receptor

Structural characterization of full-length NSF and 20S particles

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.

Structural mechanisms of phospholipid activation of the human TPC2 channel

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

Structure of a spliceosome remodelled for exon ligation

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila

Structure of the large ribosomal subunit from human mitochondria.

Structures of the calcium-activated, non-selective cation channel TRPM4.

Structures of the human mitochondrial ribosome in native states of assembly.

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

Three-dimensional structure of human γ-secretase