List of works - Dominic Alonzi

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

scientific article

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

scientific article published on 13 May 2015

An iminosugar with potent inhibition of dengue virus infection in vivo

scientific article published on 31 January 2013

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

scientific article published on 16 December 2020

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

scientific article

Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase ⬇️

scientific article published on August 15, 2011

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

scientific article

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

scientific article published on 01 January 2008

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

scientific article

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.

scientific article published on 27 April 2015

Heart failure in a woman with SLE, anti-phospholipid syndrome and Fabry's disease

scientific article

Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard.

scientific article

Iminosugar antivirals: the therapeutic sweet spot

scientific article published on April 2017

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes

scientific article

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.

scientific article published on 02 March 2016

Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release

scientific article published on 20 December 2010

Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.

scientific article published on 24 July 2017

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

scientific article

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

scientific article

Non-specific accumulation of glycosphingolipids in GNE myopathy

scientific article

Novel imino sugar α-glucosidase inhibitors as antiviral compounds.

scientific article published on 22 March 2013

Restricted processing of glycans by endomannosidase in mammalian cells.

scientific article published on 28 May 2012

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

scientific article published on April 21, 2011

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

scientific article published on 8 April 2013

Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II

scientific article published on 01 January 2018

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

scientific article

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

scientific article published on 05 November 2020

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.

scientific article published on 26 July 2016

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors

scientific article

Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis

scientific article published on 21 July 2011

Therapeutic Targets for Inhibitors of Glycosylation ⬇️

scientific article published on January 1, 2011

Urinary glycan markers for disease.

scientific article published on January 2011

List of works by Dominic Alonzi

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

An iminosugar with potent inhibition of dengue virus infection in vivo

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase ⬇️

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.

Heart failure in a woman with SLE, anti-phospholipid syndrome and Fabry's disease

Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard.

Iminosugar antivirals: the therapeutic sweet spot

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.

Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release

Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

Non-specific accumulation of glycosphingolipids in GNE myopathy

Novel imino sugar α-glucosidase inhibitors as antiviral compounds.

Restricted processing of glycans by endomannosidase in mammalian cells.

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors

Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis

Therapeutic Targets for Inhibitors of Glycosylation ⬇️

Urinary glycan markers for disease.