Search filters

List of works by Mohamed N. Seleem

A Library Approach to Cationic Amphiphilic Polyproline Helices that Target Intracellular Pathogenic Bacteria

scientific article published on 13 July 2018

A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.

scientific article

Activity of native vs. synthetic promoters in Brucella

scientific article published on 22 September 2008

Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens.

scientific article published on 25 April 2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

scientific article published on 12 February 2018

An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection

scientific article published on 30 April 2019

Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant staphylococci

scientific article published on 15 October 2014

Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius

scientific article

Antibacterial Evaluation of Synthetic Thiazole Compounds In Vitro and In Vivo in a Methicillin-Resistant Staphylococcus aureus (MRSA) Skin Infection Mouse Model

scientific article

Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens

scientific article

Antibacterial activity and safety of commercial veterinary cationic steroid antibiotics and neutral superoxidized water

scientific article published on 7 March 2018

Antibacterial activity and therapeutic efficacy of Fl-P(R)P(R)P(L)-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection.

scientific article

Antibacterial activity of novel cationic peptides against clinical isolates of multi-drug resistant Staphylococcus pseudintermedius from infected dogs

scientific article

Antibacterial and antivirulence activities of auranofin against Clostridium difficile

scientific article published on 28 September 2018

Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model.

scientific article published on 29 December 2009

Antibacterial nanotruffles for treatment of intracellular bacterial infection

scientific article published on 29 August 2020

Antibiotic Susceptibility Determination within One Cell Cycle at Single Bacterium Level by Stimulated Raman Metabolic Imaging.

scientific article published on 20 February 2018

Antimicrobial peptides and peptidomimetics - potent therapeutic allies for staphylococcal infections

scientific article

Antimicrobial photodynamic activity of gallium-substituted haemoglobin on silver nanoparticles

scientific article published on 23 October 2020

Antivirulence activity of auranofin against vancomycin-resistant enterococci: in vitro and in vivo studies

scientific article published on 26 October 2019

Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs

scientific article published on 01 December 2020

Aryl-alkyl-lysines: Membrane-Active Fungicides That Act against Biofilms of Candida albicans

scientific article published on 27 February 2017

Aryl-alkyl-lysines: Novel agents for treatment of C. difficile infection

scientific article published on 27 March 2020

Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis

scientific article published on 18 August 2017

Auranofin Rapidly Eradicates Methicillin-resistant Staphylococcus aureus (MRSA) in an Infected Pressure Ulcer Mouse Model

scientific article published on 29 April 2020

Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.

scientific article published on 10 August 2017

Balancing Physicochemical Properties of Phenylthiazole Compounds with Antibacterial Potency by Modifying the Lipophilic Side Chain

scientific article published on 27 November 2019

Biofilm-infected wounds in a dog.

scientific article published in March 2014

Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability

scientific article

Brucella abortus strain RB51 leucine auxotroph as an environmentally safe vaccine for plasmid maintenance and antigen overexpression

scientific article published on 03 October 2008

Brucella: a pathogen without classic virulence genes.

scientific article

Brucellosis: a re-emerging zoonosis.

scientific article

Chemical Space Exploration around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors

scientific article published on 21 October 2019

Cloning, expression and characterization of immunogenic aminopeptidase N from Brucella melitensis

scientific article published on November 2006

Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals.

scientific article published on 14 October 2016

Correction to "Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide"

scientific article published on 28 September 2018

Curcumin: A natural derivative with antibacterial activity against Clostridium difficile

scientific article published on 14 October 2019

Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria

scientific article published on 05 November 2019

Development of biphenylthiazoles exhibiting improved pharmacokinetics and potent activity against intracellular Staphylococcus aureus

scientific article published on 08 September 2020

Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus

scientific article published on 21 February 2017

Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus

scientific article

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

scientific article published on 14 January 2014

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

scientific article published on 21 February 2019

Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity

scientific article published on 21 October 2020

Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis

scientific article

Drug repurposing for the treatment of staphylococcal infections

scientific article

Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide

scientific article

Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells

scientific article

Effect of entF deletion on iron acquisition and erythritol metabolism by Brucella abortus 2308.

scientific article published on 10 January 2011

Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection

scientific article

Enhanced expression, detection and purification of recombinant proteins using RNA stem loop and tandem fusion tags.

scientific article

Establishment of a gene expression system in Ochrobactrum anthropi

scientific article published on October 2006

Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus

scientific article published on 11 July 2016

Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent

scientific article

From Phenylthiazoles to Phenylpyrazoles: Broadening the Antibacterial Spectrum toward Carbapenem-Resistant Bacteria

scientific article published on 19 August 2019

Identification of a Phenylthiazole Small Molecule with Dual Antifungal and Antibiofilm Activity Against Candida albicans and Candida auris

scientific article published on 12 December 2019

Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens.

scientific article published on 10 February 2016

In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates

scientific article

In Vitro Screening of an FDA-Approved Library Against ESKAPE Pathogens.

scientific article

In vitro trafficking and efficacy of core-shell nanostructures for treating intracellular Salmonella infections.

scientific article

Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov-Doebner Reactions

scientific article published on 25 September 2019

Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).

scientific article published on 24 April 2017

Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity.

scientific article published on 27 March 2017

Investigation of auranofin and gold-containing analogues antibacterial activity against multidrug-resistant Neisseria gonorrhoeae

scientific article published on 27 March 2020

Label-Free Detection and Discrimination of Bacterial Pathogens Based on Hemin Recognition.

scientific article published on 23 June 2016

Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity

scientific article published on 27 April 2019

Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness

scientific article published on 31 October 2019

N -(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

scientific article published on 15 June 2018

Nanomedicine for intracellular therapy.

scientific article published on 03 May 2012

Nanosecond electric pulses rapidly enhance the inactivation of Gram-negative bacteria using Gram-positive antibiotics

scientific article published on 22 January 2020

Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity

scientific article published on 08 October 2018

Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus

scientific article published on 11 August 2020

Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities

scientific article published on 08 April 2020

Over-expression of homologous antigens in a leucine auxotroph of Brucella abortus strain RB51 protects mice against a virulent B. suis challenge.

scientific article published on 3 March 2011

Overexpression of Brucella putative glycosyltransferase WbkA in B. abortus RB51 leads to production of exopolysaccharide.

scientific article published on 24 June 2015

Oxadiazolylthiazoles as novel and selective antifungal agents

scientific article published on 10 January 2020

Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages.

scientific article published on 7 August 2017

Peptide nucleic acids inhibit growth of Brucella suis in pure culture and in infected murine macrophages

scientific article published on 08 January 2013

Phenotypic profiling of antibiotic response signatures in Escherichia coli using Raman spectroscopy.

scientific article published on 2 December 2013

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

scientific article published on March 2017

Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action.

scientific article

Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity

scientific article published on 10 August 2019

Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity.

scientific article

Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA

scientific article published on 27 January 2020

Photolysis of Staphyloxanthin in Methicillin-Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species.

scientific article published on 30 March 2019

Plasmid-based system for high-level gene expression and antisense gene knockdown in Bartonella henselae

scientific article published on 19 June 2009

Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX

scientific article published on 13 September 2018

Rapid synthesis of bicyclic lactones via palladium-catalyzed aminocarbonylative lactonizations.

scientific article published in June 2017

Reporter genes for real-time in vive monitoring of Ochrobactrum anthropi infection.

scientific article

Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway

scientific article

Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens

scientific article

Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections

scientific article published on 6 May 2015

Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species

scientific article published on 05 May 2020

Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.

scientific article

Repurposing auranofin for the treatment of cutaneous staphylococcal infections

scientific article published on 23 January 2016

Repurposing celecoxib as a topical antimicrobial agent.

scientific article published on 28 July 2015

Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE).

scientific article published on 28 June 2018

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections

scientific article published on 26 June 2015

Repurposing niclosamide for intestinal decolonization of vancomycin-resistant enterococci.

scientific article published on 9 February 2018

Repurposing salicylamide for combating multidrug-resistant Neisseria gonorrhoeae

scientific article published on 30 September 2019

Reversal of Azole Resistance in Candida albicans by Sulfa Antibacterial Drugs

scientific article published on 23 February 2018

Screening for potent and selective anticlostridial leads among FDA-approved drugs

scientific article published on 04 March 2020

Screening of Natural Products and Approved Oncology Drug Libraries for Activity against Clostridioides difficile

scientific article published on 06 April 2020

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

scientific article published on 19 March 2019

Silica-antibiotic hybrid nanoparticles for targeting intracellular pathogens

scientific article published on 10 August 2009

Stimulated Raman Imaging Reveals Aberrant Lipogenesis as a Metabolic Marker for Azole-Resistant Candida albicans

scientific article published on 16 August 2017

Synergistic interactions of sulfamethoxazole and azole antifungal drugs against emerging multidrug-resistant Candida auris

scientific article published on 24 August 2018

Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA).

scientific article published on 7 March 2015

Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-ones

scientific article published on 17 December 2019

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

scientific article

Targeting Essential Genes in Salmonella enterica Serovar Typhimurium with Antisense Peptide Nucleic Acid ⬇️

scientific article published on September 24, 2012

Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide

scientific article published on 19 July 2016

Targeting biofilms and persisters of ESKAPE pathogens with P14KanS, a kanamycin peptide conjugate

scientific article published on 26 January 2017

Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix.

scientific article published on June 2015

Targeting intracellular pathogenic bacteria with unnatural proline-rich peptides: coupling antibacterial activity with macrophage penetration.

scientific article published on 20 August 2013

Targeting listeria monocytogenes rpoA and rpoD genes using peptide nucleic acids.

scientific article published on 16 July 2013

Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides.

scientific article published on 5 May 2014

The value of antimicrobial peptides in the age of resistance

scientific article published on 09 July 2020

Tightly regulated expression vectors for Ochrobactrum anthropi.

scientific article published on 17 March 2010

Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo

scientific article published on 22 September 2020

Vectors for enhanced gene expression and protein purification in Salmonella.

scientific article

Virulence and transcriptome profile of multidrug-resistant Escherichia coli from chicken.

scientific article

Paulina is supported by:

About Paulina

Help